Naloxone Injected into the Preoptic Region Has Hypophysiotropic and Seizurogenic Actions in Rats.

Hashimoto, Rhyuhei; Sano, Akane; Nishimura, Jun-ichi; Funabashi, Toshiya; Kimura, Fukuko

doi:10.1507/endocrj1954.38.287

Endocrinol Japon

1991

DOI: 10.1507/endocrj1954.38.287

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Naloxone Injected into the Preoptic Region Has Hypophysiotropic and Seizurogenic Actions in Rats.

Rhyuhei Hashimoto

Akane Sano

Jun-ichi Nishimura

et al.

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1992

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Cited by 6 publications

(1 citation statement)

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“…1 It was also found that such behavioral seizures accompanied epileptic spikings in the cortical electroencephalogram. 1 In the rat, the medial septal nucleus and the vertical limb of the diagonal band of Broca provide the major cholinergic projection to the hippocampal formation. 2 -3 It is known that stimulation of the medial septal nucleus enhances the release of acetylcholine from the hippocampus, 4 -7 and hippocampal neurons are excited by acetylcholine.…”

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confidence: 97%

Increases in cerebral blood flow in rat hippocampus after medial septal injection of naloxone.

Nishimura

Endo

Kimura

1992

Stroke

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Background and Purpose:In a previous study, we occasionally found that the rat given naloxone in the preoptic region develops behavioral seizures. In view of knowledge that the forebrain including the medial septal nucleus provides cholinergic projections to the hippocampal formation, the present study examined the effects of naloxone injected into the medial septal nucleus on the local blood flow in the hippocampus.Methods: A polyurethane-coated platinum electrode with a l-mm bare tip for measurement of blood flow and a guide cannula made of stainless steel tube for naloxone injection were implanted chronically into the brain. The cerebral blood flow was measured by the hydrogen clearance method in freely moving rats.Results: The injection of 50 fig naloxone caused a significant increase in hippocampal blood flow, with its peak at 20 minutes. Twenty micrograms naloxone caused a similar increase, but 10 ju.g caused only a slight increase that peaked at 30 minutes, suggesting a dose-response of naloxone effect. Hippocampal blood flow was not changed after the injection of saline into the medial septal nucleus and after the injection of naloxone into the caudate nucleus.Conclusions: Taken together with previous findings, the results suggest that endogenous opioids exert a decreasing effect on the local blood flow in the hippocampus, probably mediated by the magnocellular cholinergic neurons projecting to the hippocampus. (Stroke 1992;23:1325-1330 KEY WORDS • cerebral blood flow • hippocampus • rats • naloxone

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confidence: 97%

Increases in cerebral blood flow in rat hippocampus after medial septal injection of naloxone.

Nishimura

Endo

Kimura

1992

Stroke

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Medial septal injection of naloxone elevates acetylcholine release in the hippocampus and induces behavioral seizures in rats

Mizuno

Kimura

1996

Brain Research

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Audiogenic and audiogenic-like seizures: Locus of induction and seizure severity determine postictal prolactin patterns

García-Cairasco

Doretto

Ramalho

et al. 1996

Pharmacology Biochemistry and Behavior

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Naloxone Injected into the Preoptic Region Has Hypophysiotropic and Seizurogenic Actions in Rats.

Cited by 6 publications

References 40 publications

Increases in cerebral blood flow in rat hippocampus after medial septal injection of naloxone.

Increases in cerebral blood flow in rat hippocampus after medial septal injection of naloxone.

Medial septal injection of naloxone elevates acetylcholine release in the hippocampus and induces behavioral seizures in rats

Audiogenic and audiogenic-like seizures: Locus of induction and seizure severity determine postictal prolactin patterns

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