1991
DOI: 10.1007/bf02316864
|View full text |Cite
|
Sign up to set email alerts
|

Naloxone modulates the behavioral effects of cholinergic agonists and antagonists

Abstract: Peripheral glucose administration enhances memory in rodents and humans. Recent findings suggest that glucose may affect behavior, in part, by augmenting central cholinergic functions and by attenuating central opiate functions. The present experiments examined interactions between an opiate antagonist, naloxone, and cholinergic agents to determine whether the effects would parallel those found with glucose. Three behavioral measures were assessed: tremors, hyperactivity, and spontaneous alternation. Naloxone … Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1

Citation Types

1
11
0

Year Published

1992
1992
2017
2017

Publication Types

Select...
8

Relationship

0
8

Authors

Journals

citations
Cited by 31 publications
(12 citation statements)
references
References 44 publications
1
11
0
Order By: Relevance
“…It has also been shown that the attenuation of central cholinergic activity is involved in the expression of opioid withdrawal symptom [43,44] and impairment of learning and memory [7]. Morphine has been shown to inhibit hippocampal acetylcholine release [45,46]. Glucose, administrated peripherally or intrahippocampally, could enhance hippocampal acetylcholine release [47,48] by promoting the synthesis of acetylcholine through increasing the levels of acetyl-CoA, a precursor of acetylcholine [37].…”
Section: Discussionmentioning
confidence: 99%
“…It has also been shown that the attenuation of central cholinergic activity is involved in the expression of opioid withdrawal symptom [43,44] and impairment of learning and memory [7]. Morphine has been shown to inhibit hippocampal acetylcholine release [45,46]. Glucose, administrated peripherally or intrahippocampally, could enhance hippocampal acetylcholine release [47,48] by promoting the synthesis of acetylcholine through increasing the levels of acetyl-CoA, a precursor of acetylcholine [37].…”
Section: Discussionmentioning
confidence: 99%
“…It was proved that there was an interaction between opioids and the cholinergic systems Rush, 1986;Walker et al, 1991). Moreover injection of morphine into the medial septum could reduce ACh release in the hippocampus (Ragozzino & Gold, 1995).…”
Section: Discussionmentioning
confidence: 99%
“…However the muscarinic antagonist atropine blocked the memory-enhance induced by naloxone . Post-training administration of naloxone reversed memory impairment induced by scopolamine in a passive avoidance task and spontaneous alternation tests (Rush, 1986;Walker et al, 1991). Muscarinic agonists could antagonize the memory impairment induced by β-endorphine .…”
mentioning
confidence: 94%
See 1 more Smart Citation
“…A similar procedure was used as in past studies (Ragozzino et al, 1995; Walker et al, 1991). For the test, a rat was placed in one arm and allowed to traverse the maze freely for 15 min.…”
Section: Methodsmentioning
confidence: 99%