Nampt and Its Potential Role in Inflammation and Type 2 Diabetes

Abstract

Nicotinamide phosphoribosyltransferase Nicotinamide phosphoribosyltransferase (Nampt Nampt ) is a key nicotinamide adenine dinucleotide (NAD) NAD biosynthetic enzyme in mammals, converting nicotinamide nicotinamide into nicotinamide mononucleotide nicotinamide mononucleotide (NMN NMN ), an NAD intermediate. First identified in humans as a cytokine cytokine pre-B-cell colony enhancing factor pre-B cell colony enhancing factor (PBEF PBEF ) and subsequently described as an insulin-mimetic hormone visfatin visfatin , Nampt has recently excited the scientific interest of researchers from diverse fields, including NAD biology, metabolic regulation, and inflammation. As an NAD biosynthetic enzyme, Nampt regulates the activity of NAD-consuming enzymes such as sirtuins sirtuins and influences a variety of metabolic and stress responses. Nampt plays an important role in the regulation of insulin secretion insulin secretion in pancreatic β-cells. Nampt also functions as an immunomodulatory cytokine cytokine and is involved in the regulation of inflammatory responses. This chapter summarizes the various functional aspects of Nampt and discusses its potential roles in diseases, with special focus on type 2 diabetes mellitus (T2DM).

Quantitative Proteomic analysis on Activated Hepatic Stellate Cells reversion Reveal STAT1 as a key regulator between Liver Fibrosis and recovery

“…By microarray analysis, the transcript of ALDH2 were found to be down-regulated during the fibrogenesis process and potential used as novel serum markers of fibrosis21. NAMPT is a key nicotinamideadenime dinucleotide (NAD) biosynthetic enzyme in mammals, it has recently excited the scientific interest of researchers from diverse fields, including NAD biology, metabolic regulation and inflammation22. However, the top of enriched biological function categories of down-regulated proteins in reverted HSCs was cytoskeleton organization process (15) (Fig.…”

The NAD metabolome — a key determinant of cancer cell biology

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