Nandrolone combined with strenuous resistance training impairs myocardial proteome profile of rats

Dantas, Patrícia Sousa; Guzzoni, Vinícius; Perez, Juliana Dinéia; Arita, Danielle Yuri; Novaes, Pedro Duarte; Marcondes, Fernanda Klein; Casarini, Dulce Elena; Cunha, Tatiana Sousa

doi:10.1016/j.steroids.2021.108916

Cited by 4 publications

(3 citation statements)

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“…The increase in collagen content was observed in the group that was exposed to the combined administration of nandrolone and swimming, which is in accordance with the literature [ 7 , 23 , 45 ]. Results showed that resistance training combined with nandrolone leads to the development of hypertrophy of cardiomyocytes, increasing collagen content in cardiac muscle, systolic, and diastolic dysfunction, which confirms the occurrence of the pathological hypertrophy of the left heart [ 23 , 45 ]. This result suggests that the combined use of nandrolone and training have a synergistic effect on the enlargement of the left ventricular myocardium, which may result in cardiac dysfunction [ 23 , 45 ].…”

Section: Discussionsupporting

confidence: 92%

“…Obviously, the collagen content in cardiac muscle tissue depends on the type of physical activity to which the individual is exposed. The increase in collagen content was observed in the group that was exposed to the combined administration of nandrolone and swimming, which is in accordance with the literature [ 7 , 23 , 45 ]. Results showed that resistance training combined with nandrolone leads to the development of hypertrophy of cardiomyocytes, increasing collagen content in cardiac muscle, systolic, and diastolic dysfunction, which confirms the occurrence of the pathological hypertrophy of the left heart [ 23 , 45 ].…”

Section: Discussionsupporting

confidence: 92%

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Nandrolone Decanoate and Swimming Affects Cardiodynamic and Morphometric Parameters in the Isolated Rat Heart

Sretenovic

Živković

Srejović

et al. 2022

Life

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(1) Background: The aim of this study was to show the effects of swimming and nandrolone administration on cardiodynamic and morphometric parameters of the isolated rat heart. (2) The study included 72 Wistar rats, divided into three groups, scheduled to be sacrificed after the second, third, and fourth week. Each group was divided into four subgroups: control (T-N-), nandrolone (T-N+), swimming training (T+N-), and swimming training plus nandrolone (T+N+) group. The rats from T+N- and T+N+ swam 1 h/day, 5 days/week while ones from T-N+ and T+N+ received weekly nandrolone decanoate (20 mg/kg). The isolated hearts were perfused according to the Langendorff technique and measured parameters: dp/dt max/min, SLVP, DLVP, heart rate, and coronary flow. Hearts were fixed and stained with H/E and Masson trichrome dyes. (3) dp/dt max and dp/dt min were increased in the T-N+ group at higher perfusion pressure compared to the T-N- group. SLVP and DLVP were increased in all groups after the 4th week. Collagen content was increased in T-N+ by 403% and in T+N+ by 357% groups, while it was decreased in T+N- compared to the control after 4th week. (4) Conclusions: Nandrolone alone or combined with swimming had a deleterious effect on myocardial function and perfusion.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 92%

Nandrolone Decanoate and Swimming Affects Cardiodynamic and Morphometric Parameters in the Isolated Rat Heart

Sretenovic

Živković

Srejović

et al. 2022

Life

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“…Dantas et al [17 ▪▪ ] reported that nandrolone decanoate exposure combined with strenuous resistance training impaired the myocardial proteome profile of rats. In particular, this research group demonstrated that nandrolone decanoate, when administered at high doses, may induce detrimental effects on the proteome profile of heart tissue, altering hemodynamic parameters: considering that androgen abuse has become increasingly common among recreational athletes, these findings could be considered relevant from a clinical viewpoint.…”

Section: Resultsmentioning

confidence: 99%

Experimental studies on androgen administration in animal models: current and future perspectives

Sessa

Esposito

Salerno

2022

Current Opinion in Endocrinology, Diabetes &Amp; Obesity

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Purpose of reviewThis review aims to report the most recent (2020–2022) experimental scientific studies conducted on animal models, in order to highlight the relevant findings on the adverse effects related to androgen administration.Recent findingsForty-one studies published between January 2020 and July 2022 were selected. The majority of studies investigated the effects of one androgen, whereas only four studies analyzed the effects of two drugs. Nandrolone decanoate was the most investigated drug (20 articles), boldenone was tested in 8 articles, testosterone and stanozolol were used in 7 articles each, 17b-trenbolone, metandienone, and oxandrolone were tested in 1 article each. The articles clarify the adverse effects of androgen administration on the heart, brain, kidney, liver, reproductive and musculoskeletal systems.SummaryThe main findings of this review highlight that androgen administration increases inflammatory mediators, altering different biochemical parameters. The results concerning the reversibility of the adverse effects are controversial: on the one hand, several studies suggested that by stopping the androgen administration, the organs return to their initial state; on the other hand, the alteration of different biochemical parameters could generate irreversible organ damage. Moreover, this review highlights the importance of animal studies that should be better organized in order to clarify several important aspects related to androgen abuse to fill the gap in our knowledge in this research field.

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Impacts of Anabolic-androgenic steroid supplementation on female health and offspring: Mechanisms, side effects, and medical perspectives

Santos,

de Souza,

Goulart

et al. 2024

Saudi Pharmaceutical Journal

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Nandrolone combined with strenuous resistance training impairs myocardial proteome profile of rats

Cited by 4 publications

References 75 publications

Nandrolone Decanoate and Swimming Affects Cardiodynamic and Morphometric Parameters in the Isolated Rat Heart

Nandrolone Decanoate and Swimming Affects Cardiodynamic and Morphometric Parameters in the Isolated Rat Heart

Experimental studies on androgen administration in animal models: current and future perspectives

Impacts of Anabolic-androgenic steroid supplementation on female health and offspring: Mechanisms, side effects, and medical perspectives

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