Nandrolone Decanoate and Load Increase Remodeling and Strength in Human Supraspinatus Bioartificial Tendons

Abstract

Data suggest anabolic steroids may enhance production of bioartificial tendons and rotator cuff tendon healing in vitro. More research is necessary before such clinical use is recommended.

Biological Augmentation of Rotator Cuff Tendon Repair

“…A recent in vivo study reported AAS treatment can impair Achilles' tendon remodeling by down-regulating matrix metallopeptidase activity, and thus increase the potential for injury [47]. In an in vitro rotator cuff tendon model, human supraspinatus tenocytes treated with nandrolone decanoate and subjected to mechanical load had more organized actin cytoskeleton and increased collagen matrix remodeling and mechanical properties [68]. More research is required to determine the effect of AASs on tendon healing, but this was the first known study to document the acute effect of anabolic steroids on human rotator cuff tendon cells.…”

New perspectives in rotator cuff tendon regeneration: review of tissue engineered therapies

“…The existing studies are related to the following tissue engineering methodologies: gene transfer, in situ tissue engineering and in vitro production of bioengineered tendons. We obtained 15 experimental papers and, in more detail, 4 papers on gene therapy [11][12][13][14], 9 papers on in situ tissue engineering with the use of bioactive acellular membranes [6,[15][16][17][18][19][20][21][22] and 2 papers on in vitro tissue engineered tendons [23,24].…”

“…More than 300,000 operations are performed each year for the reconstruction of the rotator cuff in the USA, more than 30% of rotator cuff tears may be of difficult treatment or beyond repair and failure rates after primary repair have been reported to be 13%-68% for open repairs [2,5]. Revision rotator cuff surgery has also been shown to have less successful outcomes than primary repairs [6]. Tissue engineering may play a major role in the treatment of these injuries through replacement of an injured tendon segment [7].…”

In vitro study comparing two collageneous membranes in view of their clinical application for rotator cuff tendon regeneration

“…21 However, so far, few studies have been done on rotator cuff tendon regeneration by means of in situ tissue engineering and in vitro bioengineering of tendons as compared to the extensive work on bone and cartilage. 6,14,[22][23][24][25] This previous literature review, showed the necessity for future studies in this area, and, therefore, an in vitro study was performed by isolating tenocytes from the rotator cuff of normal and GC-treated rats. The tenocytes were cultured on two collagenous membranes and cell proliferation and function were recorded.…”

“…1 More than 30% of rotator cuff tears may be difficult to treat or beyond repair, failure rates after primary repair have been reported to be 13% to 68% for open repairs and revision rotator cuff surgery has been shown to have less successful outcomes than primary repairs. 1,5,6 Tissue engineering may play a major role in the treatment of these injuries through replacement of an injured tendon segment. 7 Tendons are arguably the least complex of the connective tissues with respect to their composition and architecture and this leads to the expectation that they would be more amenable to tissue-engineered approaches than other tissues.…”