Nandrolone decanoate impairs exercise-induced cardioprotection: Role of antioxidant enzymes

Chaves, Elen A.; Pereira-Junior, Pedro Paulo; Fortunato, Rodrigo S.; Masuda, Masako Oya; Carvalho, Antônio Carlos Campos de; Carvalho, Denise Pires de; Oliveira, Marcus F.; Nascimento, José

doi:10.1016/j.jsbmb.2006.01.004

Cited by 52 publications

(52 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…However, the AAS non-therapeutic use in humans is related to many health problems (3) . Chronic treatment with high doses of AAS causes reduction in the antioxidant enzymes activity induced by exercise, and, consequently, reduces the cardioprotective mechanisms during an ischemia (4) . Endurance training caused physiological hypertrophy of the left ventricle in the cardiovascular system of humans, which was associated with increase of the cavity diameter (5) , while resistance training produced concentric hypertrophy (6) .…”

Section: Introductionmentioning

confidence: 99%

Decanoato de nandrolona aumenta a parede ventricular esquerda, mas atenua o aumento da cavidade provocado pelo treinamento de natação em ratos

Soares

Abreu

Assenço

et al. 2011

Rev Bras Med Esporte

View full text Add to dashboard Cite

Anabolic androgen steroids (AASs) are drugs synthesized from testosterone. Their anabolic action is mainly due to increased synthesis and reduced degradation of muscle proteins. The purpose of this study was to investigate the effects of swimming training associated to nandrolonedecanoate treatment on the blood pressure, the myocardial dimensions, vascular reactivity. Forty Wistar male rats, aged 60 days, were divided into 4 groups (n = 10): sedentary (SN), sedentary treated (ST), trained (TN) and trained treated (TT). TN and TT animals performed a swimming training during 12 weeks and ST and TT animals received weekly nandrolonedecanoate (15mg/kg). The heart and testicles were removed and weighted. The left ventricular diameter (LVD) and left ventricular wall thickness (LVWT) had been measured with an electronic pachymeter. Systolic blood pressure (SBP) and diastolic blood pressure (DBP) was weekly measured, while the mesenteric arteries vascular reactivity was studied for its response to noradrenaline. There were no alterations in the heart weight, but the LVD increased (p < 0.05) in TN rats, while the LVWT increased (p < 0.05) in ST and TT rats, both in relation to SN. Testicle weight decreased (p < 0.05) in the ST and TT animals in relation to SN. There was no alteration in blood pressure, neither in vascular reactivity. It was concluded that swimming training increased the left ventricular diameter, while nandrolonedecanoate treatment increased mainly the left ventricular wall thickness, suggesting concentric hypertrophy.

show abstract

Section: Introductionmentioning

confidence: 99%

Decanoato de nandrolona aumenta a parede ventricular esquerda, mas atenua o aumento da cavidade provocado pelo treinamento de natação em ratos

Soares

Abreu

Assenço

et al. 2011

Rev Bras Med Esporte

View full text Add to dashboard Cite

show abstract

“…Importantly, clinical evidences suggest that some of these abnormalities, such as hypertension and dyslipidemia, are reversible after AS interruption, but others can persist for long periods or are likely irreversible. Notwithstanding in increasing the susceptibility to myocardial infarction and stroke by the above-mentioned abnormalities, chronic administration of AS has been shown to increase the damage induced by myocardial ischemia and reperfusion, which per se can aggravate the post-infarction prognosis [59][60][61]. Furthermore, recent evidences have demonstrated that therapeutic efficacy of cardioprotective maneuvers against the myocardial ischemia/reperfusion injury can be abolished by chronic exposure to AS [62].…”

Section: Cardiovascular Effectsmentioning

confidence: 99%

“…Furthermore, recent evidences have demonstrated that therapeutic efficacy of cardioprotective maneuvers against the myocardial ischemia/reperfusion injury can be abolished by chronic exposure to AS [62]. Biochemical and molecular analyses revealed that supraphysiological doses of AS are related to redox imbalance, increased proinflammatory signaling, and overactivation of renin-angiotensin system in the heart, which seems to be closely correlated to the loss of cardioprotection after myocardial ischemia/reperfusion injury [55,60,61,63].…”

Section: Cardiovascular Effectsmentioning

confidence: 99%

Neurophysiological Repercussions of Anabolic Steroid Abuse: A Road into Neurodegenerative Disorders

Seara¹,

Fortunato²,

Carvalho³

et al. 2018

Sex Hormones in Neurodegenerative Processes and Diseases

Self Cite

View full text Add to dashboard Cite

Since its discovery, several chemical modifications in the testosterone molecule have been done by pharmaceutical industry in order to improve its pharmacological effects, resulting in the creation of anabolic steroids (AS). Despite the therapeutic benefits, AS abuse has spread among elite and recreational athletes in the search for improvements on physical appearance and physical performance. Illicit use of anabolic AS has been correlated with several adverse effects, such as cardiovascular, endocrine, reproductive, and neurobehavioral dysfunctions. Recently, declines on cognitive and mnemonic performance have been demonstrated clinically and experimentally. Experimental studies have demonstrated that these neurological dysfunctions are correlated to spread neuronal apoptosis throughout important areas of the central nervous system (CNS), such as hippocampus and cortex. Several pathophysiological mechanisms have been linked to the AS-induced neurotoxicity, including redox imbalance and recruitment of pro-apoptotic downstream pathways. Furthermore, exposure to AS has arisen as a potential risk factor to the development of Alzheimer's disease. Altogether, these evidences imply that AS abuse per se induces neurodegeneration and can aggravate the prognosis of neurodegenerative diseases.

show abstract

“…Available data have shown that AAS abusing is accompanied by increased of oxidative stress condition in the liver, brain, and heart [7][8][9][10].…”

Section: Introductionmentioning

confidence: 99%

“…During physical exercise, depending on the intensity and duration, there is an increased generation of ROS and the activity of antioxidant/repair systems [5,6], thus altering the cellular redox milieu. Hence, exercise training can enhance the antioxidant capacity and lessens oxidative stress [9,10]. In addition, available data have shown that regular exercise can reduce drugs toxic effects.…”

Section: Introductionmentioning

confidence: 99%

Effects of Resistance Training Accompanied by Sustanon Abuse on Hepatotoxicity in Rats with and without Training Experience

Rahmati¹,

Arazi²,

Ghafoori³

2017

Sports Nutr Ther

View full text Add to dashboard Cite

Objectives: Abuse of anabolic androgenic steroids (AAS) has increased. Previous studies have shown that resistance training (RT) is the main exercise modality practiced by AAS abusers and people often use them in different training situations. Thus propose of this study was to evaluate the hepatotoxic effects of sustanon (Su) as an example of anabolic androgenic steroids in male rats with and without RT experience.Methods: Rats were divided into seven groups: control; Su -untreated sedentary rats (non-Su/ Sed); Sutreated sedentary rats (Su/Sed); Su -untreated trained rats (non-Su/Tr); Su -treated trained rats (Su/Tr); Suuntreated experience trained rats (non-Su/XTr); Su -treated experience trained rats (Su/XTr). Su -treated groups received sustanon 10 mg/kg intramuscularly once a week for 8 weeks. In the Tr and XTr groups, the animals climbed a 1.1 m vertical ladder, 3 days per week for 8 and 12 week, respectively. Results:After Su -treatment, the mean values of serum parameters related to hepatic function were within normal ranges. Superoxide dismutase (SOD), glutathione peroxidase (GPx), and glutathione reductase (GR) activities were higher (P<0.05) in the liver of Su treatment groups. Tr and XTr did not change any of the above parameters. Conclusion:The present findings suggest that the injection of Su during 8 weeks, either with or without RT up-regulation of enzymatic antioxidant activities. Moreover, these data demonstrated that liver function tests do not always reflect liver abnormalities particularly at the initial stages.

show abstract

Nandrolone decanoate impairs exercise-induced cardioprotection: Role of antioxidant enzymes

Cited by 52 publications

References 43 publications

Decanoato de nandrolona aumenta a parede ventricular esquerda, mas atenua o aumento da cavidade provocado pelo treinamento de natação em ratos

Decanoato de nandrolona aumenta a parede ventricular esquerda, mas atenua o aumento da cavidade provocado pelo treinamento de natação em ratos

Neurophysiological Repercussions of Anabolic Steroid Abuse: A Road into Neurodegenerative Disorders

Effects of Resistance Training Accompanied by Sustanon Abuse on Hepatotoxicity in Rats with and without Training Experience

Contact Info

Product

Resources

About