Nanging

Subacute combined degeneration of the spinal cord following recreational nitrous oxide use

“…Despite its purportedly high-rate of usage, serious side-effects as a result of its abuse remain uncommon, with less than 20 cases reported in the literature 8–18. N 2 O use occurs among the younger population, with men more likely to have experimented with the drug and also more likely to present with neurological symptoms 15. The usual amount of N 2 O bulbs inhaled in a session is usually <5, but the average of bulbs inhaled among reported cases ranges from 10–20 to >100 8–18.…”

In vitamin B 12 deficiency, higher serum folate is associated with increased total homocysteine and methylmalonic acid concentrations

“…This possibility would be analogous to the observed effects of nitric oxide on B 12 metabolism. Nitric oxide is a strong oxidizing agent that irreversibly inactivates methionine synthase by oxidizing enzyme-bound vitamin B 12 to form a free radical (27). There is no known direct effect of nitrous oxide on the mutase.…”

Novel Associations of CPS1, MUT, NOX4, and DPEP1 With Plasma Homocysteine in a Healthy Population

“…Furthermore, the same variant has been associated with the risk of pulmonary hypertension in the newborn 40 as well as the risk of veno-occlusive disease after bone marrow transplantation 38–41. Interestingly, nitrous oxide irreversibly inactivates the cytosolic enzyme methionine synthase by oxidizing enzyme-bound vitamin B 12 42, 43. Methionine synthase is a vitamin B 12 dependant enzyme that catalyzes the synthesis of methionine and methyltetrahydrofolate from homocysteine and tetrahydrofolate, the entry point of homocysteine into the remethylation pathway.…”