Nano 5% Fe–ZnO: A highly efficient and recyclable heterogeneous solid nano catalyst for the Biginelli reaction

Waghchaure, Ravindra Haribhau; Jagdale, Bapu S.; Koli, Prashant Bhimrao; Adole, Vishnu A.

doi:10.1016/j.jics.2022.100468

Cited by 21 publications

(8 citation statements)

References 67 publications

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“…The Lewis acid such as Iodine, [17] Zinc Perchlorate, [18] Zirconia sulfuric acid [19] or Bronsted acids like Phytic acid, [20] Chloroacetic acid, [21] p‐TSA [22] as well as Ionic liquid such as 3‐carboxypyridinium hydrogensulfate [Hcpy]HSO 4 , [23] [btto][p‐TSA], [24] [VSim][HSO 4 ] [25] were used as catalysts in Biginelli reaction. The Metal‐salts catalyst such as LiBr, [26] Zinc triflate, [27] Cu(OTf) 2 , [28] InCl 3 [29] as well as the Supported catalyst aluminosilicate(AlKIT‐5), [30] Al‐planted M41 (Al−M41), [31] Fe 3 O 4 @mesoporous SBA‐15, [32] Sulfonic acid‐functionalized polypropylene fiber (PPF‐SO 3 H), [33] lanthanum oxide nanoparticles such that nano‐La 2 O 3 catalyst under ultrasonic irradiation, [34] 5 % Fe–ZnO nanocatalyst, [35] were also utilized as catalysts in the Biginelli reaction.…”

Section: Introductionmentioning

confidence: 99%

Ammonium tetrafluoroborate: Novel Unprecedented Catalyst for the Synthesis of 3,4‐dihydropyrimidin‐2(1H)‐ones through Biginelli Reaction

Verma,

Chaudhary,

Verma

et al. 2024

ChemistrySelect

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A novel method has been developed to use ammonium tetrafluoroborate (NH4BF4) directly as catalyst in Biginelli reaction. A new paradigm of the Biginelli reaction for the synthesis of 3,4‐dihydropyrimidin‐2(1H)‐ones derivatives found the use of ammonium tetrafluoroborate as a novel, inexpensive, readily available, non‐toxic and mild catalyst in good to excellent yields. Notably, this is the first time that ammonium tetrafluoroborate is directly used as a catalyst in organic synthesis. So far, no organic reaction is available in literature where NH4BF4 is directly used as catalyst. However, some reactions are found where NH4BF4 is used with other catalysts as promoters or additives. The protocol developed has several advantages, such as highly efficient, simple, atom‐economical, environmentally friendly, easy synthetic and purification methods.

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Section: Introductionmentioning

confidence: 99%

Ammonium tetrafluoroborate: Novel Unprecedented Catalyst for the Synthesis of 3,4‐dihydropyrimidin‐2(1H)‐ones through Biginelli Reaction

Verma,

Chaudhary,

Verma

et al. 2024

ChemistrySelect

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“…The acidic catalyst TSA/MIL-88B activates the aldehyde, leading to the formation of intermediate A. 36 The physical characteristics of catalyst were determined by a number of techniques, including the scanning electron microscope and X-ray diffraction. Under the optimum conditions, they employed urea, acetyl acetone/ethyl acetoacetate, and aromatic aldehydes as model substrates, with Fe-ZnO acting as the catalyst and ethyl alcohol serving as the solvent.…”

Section: S C H E M E 1mentioning

confidence: 99%

“…Adole et al reported the synthesis and application of Fe‐ZnO nanocatalyst in Biginelli reaction 36 . The physical characteristics of catalyst were determined by a number of techniques, including the scanning electron microscope and X‐ray diffraction.…”

Section: Using Ethanol As Solventmentioning

confidence: 99%

Advances in Biginelli reaction: A comprehensive review

Chandravarkar,

Aneeja,

Anilkumar

2023

Journal of Heterocyclic Chem

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The Biginelli reaction, a conventional three‐component reaction provides 3,4‐dihydropyrimidin‐2(1H)‐ones/thiones via one‐pot acid catalyzed cyclocondensation of an aldehyde, a β‐keto ester, and urea or thiourea. Dihydropyrimidones are well‐known scaffolds having a wide range of pharmacological activities. So far classical Biginelli reaction has witnessed several modification and studies are still continuing in this field to develop greener and efficient methodologies. In this review, we summarize the recent advances in Biginelli reaction covering literature from 2020 to 2023.

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“…This synthetic procedure has various benefits, including decreased reaction time and highly purified product, recyclability and simplicity of catalyst isolation, and a clean and rapid workup procedure. [131] S C H E M E 2 Biginelli reaction catalyzed by 5% Fe-ZnO for the synthesis of DHPMs.…”

Section: Acidic-supported Mnp-supported Catalystsmentioning

confidence: 99%

“…Metal oxides [131] T A B L E 2 Different methodologies for the Biginelli reaction along with their comparative results.…”

mentioning

confidence: 99%

A comprehensive review on synthesis of dihydropyrimidione via Biginelli reaction catalyzed by reusable magnetic nanocatalyst (from 2020–till date)

Shakya

Kurmi

Patel

2023

Applied Organom Chemis

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The discovery of a new class of heterocyclic compounds by Pietro Biginelli in 1891 was regarded as a watershed point in the history of chemistry. Biginelli is a well‐known organic chemistry technique for generating dihydropyrimidones/thiones, which are important biological compounds. The chemistry of the Biginelli motifs has been studied in drug development because of the extensive use of multiple Biginelli adducts in various domains. The current review focuses on the magnetic reusable iron nanocatalysts, imparting their catalytic role in the Biginelli reaction, which can be impregnated with ionic liquids, Lewis's acids, metal (monometallic or bimetallic), or hybrid polymers as catalyst support. Our ongoing interest in developing environmentally friendly synthetic methodologies prompted us to investigate the utility of magnetically reusable catalysts where workup provides an eco‐friendly approach in comparison with traditional methods to provide a clear understanding of pathways leading to the formation of Biginelli adducts.

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Nano 5% Fe–ZnO: A highly efficient and recyclable heterogeneous solid nano catalyst for the Biginelli reaction

Cited by 21 publications

References 67 publications

Ammonium tetrafluoroborate: Novel Unprecedented Catalyst for the Synthesis of 3,4‐dihydropyrimidin‐2(1H)‐ones through Biginelli Reaction

Ammonium tetrafluoroborate: Novel Unprecedented Catalyst for the Synthesis of 3,4‐dihydropyrimidin‐2(1H)‐ones through Biginelli Reaction

Advances in Biginelli reaction: A comprehensive review

A comprehensive review on synthesis of dihydropyrimidione via Biginelli reaction catalyzed by reusable magnetic nanocatalyst (from 2020–till date)

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