Nano-assisted radiofrequency ablation of clinically extracted irregularly-shaped liver tumors

Shao, Yunlin; Arjun, B.; Leo, Hwa Liang; Chua, K.J.

doi:10.1016/j.jtherbio.2017.04.005

Cited by 21 publications

(13 citation statements)

References 29 publications

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“…Also carbon-based nanomaterials have been proposed to enhance the heating consequences of a RF irradiation [ 77 ]. Gannon et al highlighted the ability of single-walled carbon nanotubes to produce heat under a RF stimulation.…”

Section: Radiofrequency Responding Npsmentioning

confidence: 99%

Remotely Activated Nanoparticles for Anticancer Therapy

Racca

Cauda

2020

Nano-Micro Lett.

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Cancer has nowadays become one of the leading causes of death worldwide. Conventional anticancer approaches are associated with different limitations. Therefore, innovative methodologies are being investigated, and several researchers propose the use of remotely activated nanoparticles to trigger cancer cell death. The idea is to conjugate two different components, i.e., an external physical input and nanoparticles. Both are given in a harmless dose that once combined together act synergistically to therapeutically treat the cell or tissue of interest, thus also limiting the negative outcomes for the surrounding tissues. Tuning both the properties of the nanomaterial and the involved triggering stimulus, it is possible furthermore to achieve not only a therapeutic effect, but also a powerful platform for imaging at the same time, obtaining a nano-theranostic application. In the present review, we highlight the role of nanoparticles as therapeutic or theranostic tools, thus excluding the cases where a molecular drug is activated. We thus present many examples where the highly cytotoxic power only derives from the active interaction between different physical inputs and nanoparticles. We perform a special focus on mechanical waves responding nanoparticles, in which remotely activated nanoparticles directly become therapeutic agents without the need of the administration of chemotherapeutics or sonosensitizing drugs.

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Section: Radiofrequency Responding Npsmentioning

confidence: 99%

Remotely Activated Nanoparticles for Anticancer Therapy

Racca

Cauda

2020

Nano-Micro Lett.

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“…These probes have higher heat transfer efficiency and lower maximum temperatures, with a more uniform temperature distribution in the CNT. 126 A single-phase calcium phosphate biomineral NPs for contrast imaging under MRI to guide RFA. 127 ( Fig.…”

Section: Treatmentmentioning

confidence: 99%

Nanotechnology strategies for hepatocellular carcinoma diagnosis and treatment

et al. 2022

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“…Moreover, the effective thermal conductivity of biological tissue injected with nonspherical particles nanoparticles (e.g. carbon nanotubes (CNT)) can be quantified from (Glory et al, 2008, Shao et al, 2017b:…”

Section: Modelling Of Non-invasive Thermal Ablation Utilizing Nanoparmentioning

confidence: 99%

“…The effective electrical conductivity of the biological tissue injected with nanoparticles during RFA procedure can be computed from (Ganguly et al, 2009, Shao et al, 2017b:…”

Section: Modelling Of Non-invasive Thermal Ablation Utilizing Nanoparmentioning

confidence: 99%

Thermal ablation of biological tissues in disease treatment: A review of computational models and future directions

Singh

Melnik

2020

Electromagnetic Biology and Medicine

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Percutaneous thermal ablation has proved to be an effective modality for treating both benign and malignant tumors in various tissues. Among these modalities, radiofrequency ablation (RFA) is the most promising and widely adopted approach that has been extensively studied in the past decades. Microwave ablation (MWA) is a newly emerging modality that is gaining rapid momentum due to its capability of inducing rapid heating and attaining larger ablation volumes, and its lesser susceptibility to the heat sink effects as compared to RFA. Although the goal of both these therapies is to attain cell death in the target tissue by virtue of heating above 50 o C, their underlying mechanism of action and principles greatly differs. Computational modelling is a powerful tool for studying the effect of electromagnetic interactions within the biological tissues and predicting the treatment outcomes during thermal ablative therapies. Such a priori estimation can assist the clinical practitioners during treatment planning with the goal of attaining successful tumor destruction and preservation of the surrounding healthy tissue and critical structures. This review provides current state-ofthe-art developments and associated challenges in the computational modelling of thermal ablative techniques, viz., RFA and MWA, as well as touch upon several promising avenues in the modelling of laser ablation, nanoparticles assisted magnetic hyperthermia and noninvasive RFA. The application of RFA in pain relief has been extensively reviewed from modelling point of view. Additionally, future directions have also been provided to improve these models for their successful translation and integration into the hospital work flow.

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Nano-assisted radiofrequency ablation of clinically extracted irregularly-shaped liver tumors

Cited by 21 publications

References 29 publications

Remotely Activated Nanoparticles for Anticancer Therapy

Remotely Activated Nanoparticles for Anticancer Therapy

Nanotechnology strategies for hepatocellular carcinoma diagnosis and treatment

Thermal ablation of biological tissues in disease treatment: A review of computational models and future directions

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