Nano-based antileishmanial agents: A toxicological study on nanoparticles for future treatment of cutaneous leishmaniasis

Jebali, Ali; Kazemi, Bahram

doi:10.1016/j.tiv.2013.06.002

Cited by 110 publications

(73 citation statements)

References 25 publications

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“…Then, the cell viability of each sample was measured according to Formula 3. In the negative control, the cells were not exposed to NCRA (Jebali and Kazemi 2013).…”

Section: The Adsorption Of Aflatoxin By Ncra In Different Foodstuffsmentioning

confidence: 99%

Nanocellulose conjugated with retinoic acid: its capability to adsorb aflatoxin B1

et al. 2014

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The main aim of this study was to evaluate the adsorption of aflatoxin B1 by nanocellulose conjugated with retinoic acid (NCRA). First, aflatoxin B1 and NCRA were modeled in the Hyperchem software, and then the adsorption of aflatoxin B1 was simulated by the molecular dynamics technique. Second, nanocellulose was synthesized and conjugated with retinoic acid by cross-linker. Third, the adsorption of aflatoxin B1 and NCRA and its release were evaluated at different conditions. Fourth, its adsorption was evaluated in different foodstuffs. Sixth, its toxicity was evaluated on mouse esophageal cells (MECs). Computer-based simulation showed the adsorption of aflatoxin B1 by NCRA. This study showed that the adsorption and release were less affected by temperature and incubation time but highly affected by pH and concentration. Moreover, it was found that NCRA could adsorb aflatoxin B1 in different foodstuffs. Importantly, NCRA had no remarkable toxicity on the MECs.

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“…Then, the cell viability of each sample was measured according to Formula 3. In the negative control, the cells were not exposed to NCRA (Jebali and Kazemi 2013).…”

Section: The Adsorption Of Aflatoxin By Ncra In Different Foodstuffsmentioning

confidence: 99%

Nanocellulose conjugated with retinoic acid: its capability to adsorb aflatoxin B1

et al. 2014

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“…anti-leishmanial therapy [14][15][16][17]. Although glucantime is commonly used for the treatment of leishmaniasis, it has some side effects including increased liver enzymes and electrocardiogram changes [17].…”

Section: Methodsmentioning

confidence: 99%

Application of Nano Drugs in Treatment of Leishmaniasis

Shahcheraghi¹

2016

Glob J Infect Dis Clin Res

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Objective: Leishmaniasis is endemic in 88 countries with incidence rate of 1.5-2 million; the most common form of leishmaniasis is cutaneous leishmaniasis (CL) with 1.5 million new cases per year. Correct diagnosis and characterization of the particular parasite is important for evaluating prognosis and prescribing appropriate treatment. The current management of leishmaniasis is drug treatment of patients, to alleviate disease and vector control to reduce its transmission. Also, current treatments for visceral leishmaniasis are unsatisfactory because of their toxicity, resistance and high cost. The purpose of the present study was to review the application of nano drugs in treatment of leishmaniasis. Materials and Methods:it was used as source of research the following databases: MEDLINE, Cochrane Library, Scielo, PubMed and the database of CAPES.Results: It has been proved nanosilver particles with highly small sizes, have a good penetration into the cutaneous lesions and a good efficacy on leishmaniasis.anti-leishmanial therapy [14][15][16][17]. Although glucantime is commonly used for the treatment of leishmaniasis, it has some side effects including increased liver enzymes and electrocardiogram changes [17]. In addition, the drug is expensive, the injection is painful, and research shows that resistance of parasite to glucantime is growing in different parts of the world [17][18][19][20]. The use of nanotechnology is ever-expanding in today's technologically advanced world. This form of technology has many advantages over existing ones in many fields and medicine is one of them [20]. There are numerous devices and mechanisms developed with the aid of nanotechnology that can help cure diseases/disorders in a much better and more efficient manner [21]. The usefulness of nanotechnology can especially be seen in the treatment of infectious diseases [21,22]. This review has investigated the treatment of leishmaniasis by nano drugs. Nano drugs against leishmaniasisNanotechnology must be applied for curing infectious disease like leishmaniasis [22]. Many drugs have been made and are still being discovered, but the protozoan re-emerges showing drug resistance to the effective medications [23]. Nanotechnology has just managed to show its promise in developing a liposomal formulation called amphotericin B for leishmaniasis but has serious side effects and is not cost effective in developing countries [23][24][25]. Initial, nanodelivery systems for delivering chemotherapeutics were nanodisks impregnanted with amphotericin B, polymericnanoparticle loaded with pentamidine, primaquine, and niosomes, which still need validation at the clinical level [25][26][27][28]. There is an urgent need to take up assignments to use effective nanotechnology devices in combating this infectious disease [25][26][27][28].Different mechanisms were proposed for antimicrobial property of nanoparticles [28]. One mechanism is binding of nanoparticle to sulfur/ phosphorus-containing biomolecules such as proteins and DNA, which leads to...

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“…135 Metal oxide nanoparticles, especially titanium dioxide (TiO 2 ), silver oxide (Ag 2 O), zinc oxide (ZnO), magnesium oxide (MgO), and, more recently, selenium oxide (SeO 2 ) nanoparticles, have been extensively explored, demonstrating a significant antibacterial activity. 136 Among metals, the highest antileishmanial activity was observed for nanoparticles composed of Ag, followed by Au, Ti, Zn, and Mg. Both UV and infrared irradiation increased the antileishmanial properties of all these nanoparticles.…”

Section: Bruni Et Almentioning

confidence: 99%

Nanostructured delivery systems with improved leishmanicidal activity: a critical review

Bruni¹,

Stella²,

Giraudo³

et al. 2017

IJN

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Leishmaniasis is a vector-borne zoonotic disease caused by protozoan parasites of the genus Leishmania , which are responsible for numerous clinical manifestations, such as cutaneous, visceral, and mucocutaneous leishmaniasis, depending on the site of infection for particular species. These complexities threaten 350 million people in 98 countries worldwide. Amastigotes living within macrophage phagolysosomes are the principal target of antileishmanial treatment, but these are not an easy target as drugs must overcome major structural barriers. Furthermore, limitations on current therapy are related to efficacy, toxicity, and cost, as well as the length of treatment, which can increase parasitic resistance. Nanotechnology has emerged as an attractive alternative as conventional drugs delivered by nanosized carriers have improved bioavailability and reduced toxicity, together with other characteristics that help to relieve the burden of this disease. The significance of using colloidal carriers loaded with active agents derives from the physiological uptake route of intravenous administered nanosystems (the phagocyte system). Nanosystems are thus able to promote a high drug concentration in intracellular mononuclear phagocyte system (MPS)-infected cells. Moreover, the versatility of nanometric drug delivery systems for the deliberate transport of a range of molecules plays a pivotal role in the design of therapeutic strategies against leishmaniasis. This review discusses studies on nanocarriers that have greatly contributed to improving the efficacy of antileishmaniasis drugs, presenting a critical review and some suggestions for improving drug delivery.

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Nano-based antileishmanial agents: A toxicological study on nanoparticles for future treatment of cutaneous leishmaniasis

Cited by 110 publications

References 25 publications

Nanocellulose conjugated with retinoic acid: its capability to adsorb aflatoxin B1

Nanocellulose conjugated with retinoic acid: its capability to adsorb aflatoxin B1

Application of Nano Drugs in Treatment of Leishmaniasis

Nanostructured delivery systems with improved leishmanicidal activity: a critical review

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