Nano-bio-computing lipid nanotablet

Seo, Jinyoung; Kim, Sungi; Park, Ha H.; Choi, Da Yeon; Nam, Jwa‐Min

doi:10.1126/sciadv.aau2124

Cited by 33 publications

(31 citation statements)

References 49 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Building on recent advances, these technologies will continue to integrate further. There is even potentially a scope to reverse their traditional roles, where DNA acts as a geometrical scaffold and lipids as a biological mediator, for example, with hydrophobically modified DNA nanostructures acting like lipids and assembling at phase interfaces [149], and with lipids that are able to act as scaffolds for the spatial arrangement of DNA logic circuits [150] and protect them from degradation [151]. By integrating the latest in protein nanotechnology, DNA scaffolds have also been used to synthesise protein pores that only assemble when the requisite DNA is present [152].…”

Section: Discussionmentioning

confidence: 99%

The Fusion of Lipid and DNA Nanotechnology

Darley

Singh

Surace

et al. 2019

Genes

View full text Add to dashboard Cite

Lipid membranes form the boundary of many biological compartments, including organelles and cells. Consisting of two leaflets of amphipathic molecules, the bilayer membrane forms an impermeable barrier to ions and small molecules. Controlled transport of molecules across lipid membranes is a fundamental biological process that is facilitated by a diverse range of membrane proteins, including ion-channels and pores. However, biological membranes and their associated proteins are challenging to experimentally characterize. These challenges have motivated recent advances in nanotechnology towards building and manipulating synthetic lipid systems. Liposomes—aqueous droplets enclosed by a bilayer membrane—can be synthesised in vitro and used as a synthetic model for the cell membrane. In DNA nanotechnology, DNA is used as programmable building material for self-assembling biocompatible nanostructures. DNA nanostructures can be functionalised with hydrophobic chemical modifications, which bind to or bridge lipid membranes. Here, we review approaches that combine techniques from lipid and DNA nanotechnology to engineer the topography, permeability, and surface interactions of membranes, and to direct the fusion and formation of liposomes. These approaches have been used to study the properties of membrane proteins, to build biosensors, and as a pathway towards assembling synthetic multicellular systems.

show abstract

Section: Discussionmentioning

confidence: 99%

The Fusion of Lipid and DNA Nanotechnology

Darley

Singh

Surace

et al. 2019

Genes

View full text Add to dashboard Cite

show abstract

“…The membrane proteins, as nanoscale information‐processing agents, laterally diffuse and interact with each other, forming dynamic networks that alter cell states in response to changes in surroundings . On cellular membranes, computing units respond to diverse forms of energy; for example, G protein‐coupled receptors, voltage‐gated, or light‐gated channels sense and process extracellular information (delivered as small molecules, electrical potentials, and light) by dynamically switching their structures in response to the stimuli . Inspired by the unique roles of cellular membranes in biological information processing, we have launched an effort to use a lipid bilayer as a “chemical circuit board” for nanostructure circuits, with the ultimate goal of exploring previously unexplored opportunities in nano‐bio computing.…”

Section: Biocomputing With Nanostructures On Lipid Bilayersmentioning

confidence: 99%

“…As the first step toward achieving nano‐bio computing on lipid bilayers, we developed “lipid nanotablet,” which uses single nanoparticles as logic units and an SLB as a chemical circuit board ( Figure a) . On lipid nanotablet, we demonstrated digital design principles such as Boolean logic, cascading, and fan‐in/fan‐out.…”

Section: Biocomputing With Nanostructures On Lipid Bilayersmentioning

confidence: 99%

“…Each nanoparticle species is distinguished on the basis of its signal (color), mobility (R or F), and function (subscripted number). Reproduced under the terms and conditions of the Creative Commons Attribution License 4.0 . Copyright 2019, The Authors, published by American Association for the Advancement of Science.…”

Section: Biocomputing With Nanostructures On Lipid Bilayersmentioning

confidence: 99%

“…The most notable example is a system of nanostructures carrying out computational tasks on lipid bilayers (Figure c). Recently, we developed a nano‐bio computing platform based on lipid bilayers, where information flow is mediated by direct interactions among nanoparticles tethered to a 2D lipid bilayer surface . On this platform (termed “lipid nanotablet”), information‐processing nanostructures on the fluidic 2D surface are used as computing units for digital computation.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Biocomputing with Nanostructures on Lipid Bilayers

Seo

Kim

Park

et al. 2019

Small

Self Cite

View full text Add to dashboard Cite

Biocomputation is the algorithmic manipulation of biomolecules. Nanostructures, most notably DNA nanostructures and nanoparticles, become active substrates for biocomputation when modified with stimuli‐responsive, programmable biomolecular ligands. This approach—biocomputing with nanostructures (“nano‐bio computing”)—allows autonomous control of matter and information at the nanoscale; their dynamic assemblies and beneficial properties can be directed without human intervention. Recently, lipid bilayers interfaced with nanostructures have emerged as a new biocomputing platform. This new nano‐bio interface, which exploits lipid bilayers as a chemical circuit board for information processing, offers a unique reaction space for realizing nanostructure‐based computation at a previously unexplored dimension. In this Concept, recent advances in nano‐bio computing are briefly reviewed and the newly emerging concept of biocomputing with nanostructures on lipid bilayers is introduced.

show abstract

Emerging Plasmonic Assemblies Triggered by DNA for Biomedical Applications

Zhu

Lin

et al. 2020

Adv Funct Materials

View full text Add to dashboard Cite

Plasmonic gold nanocrystal represents plasmonic metal nanomaterials, and has a variety of unique and beneficial properties, such as optical signal enhancement, catalytic activity, and photothermal properties tuned by local temperature, which are useful in physical, chemical, and biological applications. In addition, the inherent properties of predictable programmability, sequence specificity, and structural plasticity provide DNA nanostructures with precise controllability, spatial addressability, and targeting recognition, serving as ideal ligands to link or position building blocks during the self‐assembly process. Self‐assembly is a common technique for the organization of prefabricated and discrete nanoparticle blocks for the construction of extremely sophisticated nanocomposites. To this end, the integration of DNA nanotechnology with Au nanomaterials, followed by assembly of DNA‐functionalized Au nanomaterials can form novel functional Au nanomaterials that are difficult to obtain through conventional methods. Here, recent progress in DNA‐assembled Au nanostructures of various shapes is summarized, and their functions are discussed. The fabrication strategies that employ DNA for the self‐assembly of Au nanostructures, including dimers, tetramers, satellites, nanochains, and other nanostructures with more complex geometric configurations are first described. Then, the characteristic optical properties and applications of biosensing, bioimaging, drug delivery, and therapy are discussed. Finally, the remaining challenges and prospects are elucidated.

show abstract

Nano-bio-computing lipid nanotablet

Abstract: A supported lipid bilayer is used as a chemical circuit board to carry out molecular computation with a network of nanoparticles.

Cited by 33 publications

References 49 publications

The Fusion of Lipid and DNA Nanotechnology

The Fusion of Lipid and DNA Nanotechnology

Biocomputing with Nanostructures on Lipid Bilayers

Emerging Plasmonic Assemblies Triggered by DNA for Biomedical Applications

Contact Info

Product

Resources

About