“Nano-Biomaterials” – A New Approach Concerning Multi-Drug Resistant Tuberculosis (MDR-TB)

Saravanan, Muthupandian; Duche, Kebret; Asmelash, Tsehaye; Gebreyesus, Araya; Negash, Letemichael; Tesfay, Amanuel; Hailekiros, Haftamu; Niguse, Selam; Gopinath, V.; Barik, Sisir K.

doi:10.2174/2211738503666150415230743

Cited by 8 publications

(3 citation statements)

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“…This is attributed to the particle size, as Met-AgNPs were smaller in size than Aq-AgNPs. Small AgNPs may readily diffuse or may pierce bacterial cell membranes to stop the growth of the bacteria by interfering with the processes of their natural metabolism (Mubarak et al 2018 ; Saravanan et al 2015 ). Smaller AgNPs have more surface area than larger ones, which results in stronger antibacterial activity (Kvitek et al 2008 ).…”

Section: Resultsmentioning

confidence: 99%

Antibacterial, antioxidant, and anticancer potential of green fabricated silver nanoparticles made from Viburnum grandiflorum leaf extract

Talib,

Mehmood,

Amjad

et al. 2024

Bot Stud

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Background Recently, researchers are focusing on creating new tools to combat the antibiotic resistant bacteria and malignancy issues, which pose significant threats to humanity. Biosynthesized silver nanoparticles (AgNPs) are thought to be a potential solution to these issues. The biosynthesis method, known for its environmentally friendly and cost-effective characteristics, can produce small-sized AgNPs with antimicrobial and anticancer properties. In this study, AgNPs were bio-fabricated from the distilled water and methanolic extracts of Viburnum grandiflorum leaves. Physio-chemical characterization of the bio-fabricated AgNPs was conducted using UV-visible spectroscopy, scanning electron microscopy, energy dispersive X-ray, and X-ray diffraction analysis. Results AgNPs produced from the methanol extract were smaller in size (12.28 nm) compared to those from the aqueous extract (17.77 nm). The bioengineered AgNPs exhibited a circular shape with a crystalline nature. These biosynthesized AgNPs demonstrated excellent bactericidal activity against both gram-negative (Pseudomonas aeruginosa) and gram-positive (Staphylococcus aureus) bacteria. Highest antibacterial activity was observed with the methanol extract against P. aeruginosa (14.66 ± 0.74 mm). AgNPs from the methanol extract also displayed the highest antioxidant activity, with an IC50 value of 188.00 ± 2.67 μg/mL against 2,2-diphenyl-1-picrylhydrazyl (DPPH). Furthermore, AgNPs exhibited notable cytotoxic activity against Rhabdomyosarcoma cell line (RD cell) of human muscle cancer cell. The IC50 values calculated from the MTT assay were 26.28 ± 1.58 and 21.49 ± 1.44 μg/mL for AgNPs synthesized from aqueous and methanol extracts, respectively. Conclusion The methanol extract of V. grandiflorum leaves demonstrates significant potential for synthesizing AgNPs with effective antibacterial, antioxidant, and anticancer actions, making them applicable in various biomedical applications.

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Section: Resultsmentioning

confidence: 99%

Antibacterial, antioxidant, and anticancer potential of green fabricated silver nanoparticles made from Viburnum grandiflorum leaf extract

Talib,

Mehmood,

Amjad

et al. 2024

Bot Stud

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“…Nanodrug delivery systems have great potential in the translation of MRSA treatments towards better therapeutic outcomes and represent a significant approach for overcoming bacterial MDR. Finally, the nano-biomaterials have been suggested for the treatment of MDR-TB [ 130 ]. AMPs-based nano-formulations have significantly improved the therapeutic effects of AMPs in various bacterial infections models, including bloodstream (specifically sepsis), pulmonary, chronic wound, and gastrointestinal infections, by ameliorating their hydrolytic stability, in vivo half-life, and solubility, as well as reducing the cytotoxicity and hemolysis [ 131 ].…”

Section: Nanocarriersmentioning

confidence: 99%

Multidrug Resistance (MDR): A Widespread Phenomenon in Pharmacological Therapies

et al. 2022

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Multidrug resistance is a leading concern in public health. It describes a complex phenotype whose predominant feature is resistance to a wide range of structurally unrelated cytotoxic compounds, many of which are anticancer agents. Multidrug resistance may be also related to antimicrobial drugs, and is known to be one of the most serious global public health threats of this century. Indeed, this phenomenon has increased both mortality and morbidity as a consequence of treatment failures and its incidence in healthcare costs. The large amounts of antibiotics used in human therapies, as well as for farm animals and even for fishes in aquaculture, resulted in the selection of pathogenic bacteria resistant to multiple drugs. It is not negligible that the ongoing COVID-19 pandemic may further contribute to antimicrobial resistance. In this paper, multidrug resistance and antimicrobial resistance are underlined, focusing on the therapeutic options to overcome these obstacles in drug treatments. Lastly, some recent studies on nanodrug delivery systems have been reviewed since they may represent a significant approach for overcoming resistance.

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“…In addition to these, nanobiomaterials are also used for antimicrobial activities [50][51][52] . The emerging applications are found in cancer diagnosis and therapy [53][54][55][56][57][58] , for detecting and treating tumors 59 , photodynamic therapy [60][61] , tuberculosis 62 and dental implants 63 . Nanobiomaterials are suitable tags for cellular detections, in cell and molecular biology [64][65] .…”

Section: Nanobiomaterials (Nbm) and Their Categoriesmentioning

confidence: 99%

Untitled

2017

IJPSR

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Nanobiomaterials are very effective components for several biomedical and pharmaceutical studies. Among the metallic, organic, ceramic and polymeric nanomaterials, metallic nanomaterials have shown certain prominent biomedical applications. Enormous works have been done to synthesize, analyse and administer the metallic nanoparticles for various kinds of medical and therapeutic applications, during the last forty years. In these analyses, the prominent biomedical applications of ten metallic nanobiomaterials have been reviewed from various sources and works. It has been found that almost nine of them are used in a very wide spectrum of medical and theranostic applications.

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“Nano-Biomaterials” – A New Approach Concerning Multi-Drug Resistant Tuberculosis (MDR-TB)

Cited by 8 publications

References 0 publications

Antibacterial, antioxidant, and anticancer potential of green fabricated silver nanoparticles made from Viburnum grandiflorum leaf extract

Antibacterial, antioxidant, and anticancer potential of green fabricated silver nanoparticles made from Viburnum grandiflorum leaf extract

Multidrug Resistance (MDR): A Widespread Phenomenon in Pharmacological Therapies

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