Nano-biosensors and their relevance in tissue engineering

Solaimuthu, Anbuthiruselvan; Vijayan, Ane Nishitha; Murali, Padmaja; Korrapati, Purna Sai

doi:10.1016/j.cobme.2019.12.005

Cited by 65 publications

(28 citation statements)

References 31 publications

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“…Therefore, progress in research related to nanosensors depends on a detection system that is ultra-sensitive and can combine low-cost, high-speed and simple instrumentation. In this context, the future for these nanotechnology-based systems is to explore the integration of various properties (optical, magnetic, electrochemical and biological) to promote a more precise and fast response for the diagnosis [121]. As demonstrated throughout this topic, nanotechnology has been extensively investigated in the development of new detection systems.…”

Section: Titanium Dioxidementioning

confidence: 99%

How can nanotechnology help to combat COVID-19? Opportunities and urgent need

et al. 2020

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Incidents of viral outbreaks have increased at an alarming rate over the past decades. The most recent human coronavirus known as COVID-19 (SARS-CoV-2) has already spread around the world and shown R 0 values from 2.2 to 2.68. However, the ratio between mortality and number of infections seems to be lower in this case in comparison to other human coronaviruses (such as severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome coronavirus (MERS-CoV)). These outbreaks have tested the limits of healthcare systems and have posed serious questions about management using conventional therapies and diagnostic tools. In this regard, the use of nanotechnology offers new opportunities for the development of novel strategies in terms of prevention, diagnosis and treatment of COVID-19 and other viral infections. In this review, we discuss the use of nanotechnology for COVID-19 virus management by the development of nano-based materials, such as disinfectants, personal protective equipment, diagnostic systems and nanocarrier systems, for treatments and vaccine development, as well as the challenges and drawbacks that need addressing.

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Section: Titanium Dioxidementioning

confidence: 99%

How can nanotechnology help to combat COVID-19? Opportunities and urgent need

et al. 2020

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“…Based on the thickness of the layer at the metal surface, the SPR phenomenon results in the declined intensity of the reflected light relative to the incident light at a specific angle known as the resonance angle. The decrease in intensity is proportional to the mass on the surface [ 90 , 91 ]. Moreover, the SPR method relies on refractive index variations connected with the binding of the analyte to the biorecognition element on the transducer or SPR sensor.…”

Section: Biosensormentioning

confidence: 99%

“…When the SPR phenomenon is extended to metal-based nanomaterials, such as gold and silver, NPs have given rise to a new phenomenon called localized surface plasmon resonance (LSPR). The main difference between LSPR and SPR phenomena is that plasma oscillations are governed by the total internal reflection locally at the surface of the nanostructure instead of at the metal surface [ 85 , 90 , 91 ]. The SPR-based DNA biosensor was developed by Rashidi et al for detecting a donkey meat marker using gold nanostars.…”

Section: Biosensormentioning

confidence: 99%

A Review on Biosensors and Recent Development of Nanostructured Materials-Enabled Biosensors

Naresh

Lee

2021

Sensors

1,076

427

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A biosensor is an integrated receptor-transducer device, which can convert a biological response into an electrical signal. The design and development of biosensors have taken a center stage for researchers or scientists in the recent decade owing to the wide range of biosensor applications, such as health care and disease diagnosis, environmental monitoring, water and food quality monitoring, and drug delivery. The main challenges involved in the biosensor progress are (i) the efficient capturing of biorecognition signals and the transformation of these signals into electrochemical, electrical, optical, gravimetric, or acoustic signals (transduction process), (ii) enhancing transducer performance i.e., increasing sensitivity, shorter response time, reproducibility, and low detection limits even to detect individual molecules, and (iii) miniaturization of the biosensing devices using micro-and nano-fabrication technologies. Those challenges can be met through the integration of sensing technology with nanomaterials, which range from zero- to three-dimensional, possessing a high surface-to-volume ratio, good conductivities, shock-bearing abilities, and color tunability. Nanomaterials (NMs) employed in the fabrication and nanobiosensors include nanoparticles (NPs) (high stability and high carrier capacity), nanowires (NWs) and nanorods (NRs) (capable of high detection sensitivity), carbon nanotubes (CNTs) (large surface area, high electrical and thermal conductivity), and quantum dots (QDs) (color tunability). Furthermore, these nanomaterials can themselves act as transduction elements. This review summarizes the evolution of biosensors, the types of biosensors based on their receptors, transducers, and modern approaches employed in biosensors using nanomaterials such as NPs (e.g., noble metal NPs and metal oxide NPs), NWs, NRs, CNTs, QDs, and dendrimers and their recent advancement in biosensing technology with the expansion of nanotechnology.

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“…MOS with multifunctional properties able to monitor molecules from biological systems represent a step forward in the development of more complex autonomous medical decision-making systems. Enzyme-based biosensors containing MOS have several advantages such as: (1) chemical stability in various environments (Zheng et al, 2020), (2) high energy efficiency (Solaimuthu et al, 2020), (3) good sensitivity (Yi et al, 2020), and (4) adaptability to specific working conditions (Han et al, 2019). There are several issues to overcome in order to implement MOS in biosensing applications: organic/inorganic interface compatibility, increasing the carrier charge mobility, decreasing electron-hole recombinations, and finding facile synthesis techniques.…”

Section: Introductionmentioning

confidence: 99%

Metal Oxides-Based Semiconductors for Biosensors Applications

Ionel

Eneşca

2020

Front. Chem.

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The present mini review contains a concessive overview on the recent achievement regarding the implementation of a metal oxide semiconductor (MOS) in biosensors used in biological and environmental systems. The paper explores the pathway of enhancing the sensing characteristics of metal oxides by optimizing various parameters such as synthesis methods, morphology, composition, and structure. Four representative metal oxides (TiO 2 , ZnO, SnO 2 , and WO 3 ) are presented based on several aspects: synthesis method, morphology, functionalizing molecules, detection target, and limit of detection (LOD).

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Nano-biosensors and their relevance in tissue engineering

Cited by 65 publications

References 31 publications

How can nanotechnology help to combat COVID-19? Opportunities and urgent need

How can nanotechnology help to combat COVID-19? Opportunities and urgent need

A Review on Biosensors and Recent Development of Nanostructured Materials-Enabled Biosensors

Metal Oxides-Based Semiconductors for Biosensors Applications

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