Nano-bubble hydrogen water: An effective therapeutic agent against inflammation related disease caused by viral infection in zebrafish model

Li, Chen; Cao, Yiran; Kohei, Fukuda; Hao, Haihong; Peng, Guang; Cheng, Chong; Ye, Jing

doi:10.1016/j.virs.2022.01.023

Cited by 7 publications

(1 citation statement)

References 33 publications

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“…In short, researchers favour NBs for their unique advantages, characterised by their extremely small size and unique stability. At present, NBs find applications in two main aspects: as a method or material in various fields (Babu & Amamcharla, 2022), and as auxiliary agent to overcome inherent limitations (Duan et al ., 2020; Xiao & Miwa, 2021; Li et al ., 2022), thereby offering a broader scope for utilisation.…”

Section: Introductionmentioning

confidence: 99%

CO₂‐NBs‐ assisted enzymatic hydrolysis as a new green approach for extraction of phenolic compounds from rhizomes of Polygonatum cyrtonema Hua

Ai,

Ettoumi,

et al. 2024

Int J of Food Sci Tech

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SummaryThe integration of carbon dioxide‐nanobubbles (CO2‐NBs) with cellulase has led to the development of an innovative extraction system for phenolic compound retrieval from P. cyrtonema (Polygonatum cyrtonema) Hua rhizomes. Four critical factors influencing on CO2‐NBs‐cellulase were methodically investigated and optimised through single‐factor experiments. The optimal experimental conditions are 30 cycles, 0.35 MPa, pH 5.45 and 0.025 g/mL cellulase aqueous solution. The stability of system was characterised meticulously, indicating the viability for at least 24 h. Comparative assessment of bioactive constituents and antioxidant activity demonstrated exceptional extraction efficiency and potential synergistic effects of CO2‐NBs‐cellulase. Synergistic effects and reaction mechanisms during extraction were explored using Fourier‐transform infrared spectroscopy, differential scanning calorimetry and scanning electron microscopy, which contributed to mechanism understanding with significant alterations in partial structure and heightened thermal stability we found. In essence, this study introduces an eco‐friendly, energy‐efficient extraction system paradigm based on a novel nanobubble‐enzyme binding approach.

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Section: Introductionmentioning

confidence: 99%

CO₂‐NBs‐ assisted enzymatic hydrolysis as a new green approach for extraction of phenolic compounds from rhizomes of Polygonatum cyrtonema Hua

Ai,

Ettoumi,

et al. 2024

Int J of Food Sci Tech

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In Situ Piezoelectric‐Catalytic Anti‐Inflammation Promotes the Rehabilitation of Acute Spinal Cord Injury in Synergy

You,

Jiang,

Zheng

et al. 2024

Advanced Materials

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Relieving inflammation via scavenging toxic reactive oxygen species (ROS) during the acute phase of spinal cord injury (SCI) has been proved to be an effective strategy to mitigate secondary spinal cord injury and improve recovery of motor function. However, commonly used corticosteroid anti‐inflammatory drugs such as methylprednisolone show adverse side effects which may induce gastrointestinal bleeding, femoral head necrosis and an increased risk of wound infection. Fortunately, hydrogen (H2), featuring selective antioxidant performance, easy penetrability and excellent biosafety, is being extensively investigated as a potential anti‐inflammatory therapeutic gas for the treatment of SCI. In this work, by a facile in situ growth approach of gold nanoparticles (AuNPs) on the piezoelectric BaTiO3, a particulate nanocomposite with Schottky heterojunction (Au@BT) has been synthesized, which can generate H2 continuously by catalyzing H+ reduction through piezoelectric catalysis. Furthermore, theoretical calculations were employed to reveal the piezoelectric catalytic mechanism of Au@BT. Transcriptomics analysis and nontargeted large‐scale metabolomic analysis reveal that the deeper mechanism of the neuroprotective effect of H2 therapy based on Au@BT + US. The as‐prepared Au@BT nanoparticles have been first explored as a flexible hydrogen gas generator for efficient anti‐inflammatory and pro‐repair application for SCI therapy. This study highlights a promising prospect of nanocatalytic medicine for disease treatments by catalyzing H2 production, thus offering a significant alternative to conventional approaches against refractory spinal cord injury.This article is protected by copyright. All rights reserved

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Hydrogen administration improves the growth performance of juvenile largemouth bass (Micropterus salmoides) by increasing feed intake, reducing serum lipids, activating mTOR and Nrf2 signaling pathways, and altering the intestinal microbiota

Hu,

Huang,

Wang

et al. 2023

Aquaculture Reports

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Nano-bubble hydrogen water: An effective therapeutic agent against inflammation related disease caused by viral infection in zebrafish model

Cited by 7 publications

References 33 publications

CO₂‐NBs‐ assisted enzymatic hydrolysis as a new green approach for extraction of phenolic compounds from rhizomes of Polygonatum cyrtonema Hua

CO₂‐NBs‐ assisted enzymatic hydrolysis as a new green approach for extraction of phenolic compounds from rhizomes of Polygonatum cyrtonema Hua

In Situ Piezoelectric‐Catalytic Anti‐Inflammation Promotes the Rehabilitation of Acute Spinal Cord Injury in Synergy

Hydrogen administration improves the growth performance of juvenile largemouth bass (Micropterus salmoides) by increasing feed intake, reducing serum lipids, activating mTOR and Nrf2 signaling pathways, and altering the intestinal microbiota

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Nano-bubble hydrogen water: An effective therapeutic agent against inflammation related disease caused by viral infection in zebrafish model

Cited by 7 publications

References 33 publications

CO2‐NBs‐ assisted enzymatic hydrolysis as a new green approach for extraction of phenolic compounds from rhizomes of Polygonatum cyrtonema Hua

CO2‐NBs‐ assisted enzymatic hydrolysis as a new green approach for extraction of phenolic compounds from rhizomes of Polygonatum cyrtonema Hua

In Situ Piezoelectric‐Catalytic Anti‐Inflammation Promotes the Rehabilitation of Acute Spinal Cord Injury in Synergy

Hydrogen administration improves the growth performance of juvenile largemouth bass (Micropterus salmoides) by increasing feed intake, reducing serum lipids, activating mTOR and Nrf2 signaling pathways, and altering the intestinal microbiota

Contact Info

Product

Resources

About

CO₂‐NBs‐ assisted enzymatic hydrolysis as a new green approach for extraction of phenolic compounds from rhizomes of Polygonatum cyrtonema Hua

CO₂‐NBs‐ assisted enzymatic hydrolysis as a new green approach for extraction of phenolic compounds from rhizomes of Polygonatum cyrtonema Hua