Nano-carbohydrates: Synthesis and application in genetics, biotechnology, and medicine

Jebali, Ali; Nayeri, Elham Khajeh; Roohana, Sima; Aghaei, Shiva; Ghaffari, Maede; Daliri, Karim; Fuente, Garcia

doi:10.1016/j.cis.2016.11.002

Cited by 15 publications

(11 citation statements)

References 172 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Functionalized carbohydrate scaffolds are often related to the concept of multivalency. Multivalency can be defined as the “ability of a particle (or molecule) to bind another particle (or molecule) via multiple and simultaneous non-covalent interactions” [ 41 ]. Knowing that: (1) carbohydrates are involved in a wide range of biological processes via non covalent interactions with lectins (which are specific carbohydrate proteins found inside and outside cells in animals, plants and microorganisms) [ 42 , 43 , 44 , 45 ]; (2) the binding affinity between carbohydrates and proteins is very weak, then, the multivalency concept a.k.a.…”

Section: Functionalized Carbohydrate Scaffoldsmentioning

confidence: 99%

Recent Advances in the Chemistry of Glycoconjugate Amphiphiles

2018

View full text Add to dashboard Cite

Glyconanoparticles essentially result from the (covalent or noncovalent) association of nanometer-scale objects with carbohydrates. Such glyconanoparticles can take many different forms and this mini review will focus only on soft materials (colloids, liposomes, gels etc.) with a special emphasis on glycolipid-derived nanomaterials and the chemistry involved for their synthesis. Also this contribution presents Low Molecular Weight Gels (LMWGs) stabilized by glycoconjugate amphiphiles. Such soft materials are likely to be of interest for different biomedical applications.

show abstract

Section: Functionalized Carbohydrate Scaffoldsmentioning

confidence: 99%

Recent Advances in the Chemistry of Glycoconjugate Amphiphiles

2018

View full text Add to dashboard Cite

show abstract

“…Biomolecules such as oligonucleotides, polysaccharides, and proteins are antigenic and all are nanometer-sized [1]. Table 1 shows the size distribution of some immunological structures [2].…”

Section: Introductionmentioning

confidence: 99%

The Use of Nanobiotechnology in Immunology and Vaccination

2021

Self Cite

View full text Add to dashboard Cite

Nanotechnology uses the unique properties of nanostructures with a size of 1 to 200 nanometers. Different nanoparticles have shown great promise for the production of new vaccines and drugs. Nanostructures can be used to deliver immunological compounds more effectively than microstructures to target sites. Different nanostructures can be applied to form a new generation of vaccines, adjuvants, and immune system drugs. The goal of nanotechnology is to better respond to a wide range of infectious and non-infectious diseases.

show abstract

“…22,23 The multivalent properties of carbohydrate-based ligands have been used to improve the sensitivity and selectivity of the targeted recognition in AuNP glycoconjugates (AuNP-GCs). 24,25 Carbohydrates are important bioactive compounds in cellular metabolism, protein, and lipid functionalization. 26 Although their synthesis is not encoded by the genetic material, their metabolism is strictly regulated at the genetic level.…”

Section: ■ Introductionmentioning

confidence: 99%

Greener One-Pot Synthesis of Gold Nanoparticle Glycoconjugates Using Functionalized Sugars

Yazgan

Osonga

Miller

et al. 2021

ACS Agric. Sci. Technol.

View full text Add to dashboard Cite

Carbohydrates have been used to decorate metallic nanoparticles to form nanoglycoconjugates. However, the synthetic conditions typically require the utilization of increased temperatures and other reagents that negatively impact the stability of the conjugates. For the first time, this study is reporting the synthesis of gold–nanoparticle glycoconjugates (AuNP-GCs) in aqueous media at ambient temperatures. A series of sugars and small molecules acting as reducing, capping, and stabilizing agents were reacted with gold(III) chloride salt to produce the AuNP-GCs. Specifically, β-d-lactose, d-mannose, and d-galactose were utilized to synthesize (N-lactosyl)-5-aminosalicylic acid gold nanoparticles (L5AS-AuNPs), (N-galactosyl)-5-aminosalicylic acid gold nanoparticles (G5AS-AuNPs), and (N,N′-dilactosyl)diaminodiphenylethylene gold nanoparticles (LAEA-AuNPs), respectively. The formation of AuNP-GCs was monitored via ultraviolet–visible spectrophotometry, and the results confirmed the presence of the characteristic surface plasmon resonance peaks. Additional characterization data using transmission electron microscopy, energy-dispersive X-ray spectroscopy, and X-ray diffraction (XRD) confirmed the formation of AuNP-GCs. Of the AuNP-GCs produced, the XRD data confirmed that L5AS-AuNPs (∼20 nm), G5AS-AuNPs (∼5 nm), and LAEA-AuNPs (∼50 nm) were crystalline with predominant 111 orientations. All of the AuNP-GCs exhibited unique fluorescence and Raman activities except 4,4′-diaminodiphenylsulfone (PSA). The analytical enhancement factor, an important characterization parameter for assessing the surface-enhanced Raman scattering effect, was determined. LAEA-AuNPs resulted in enhancement factors of 11 × 104 and 6 × 104. LPSA-AuNPs resulted in enhancement factors of 8 × 104 and 6 × 104. The resulting AuNP-GCs retained stability for up to a year. 1H and 13C nuclear magnetic resonance spectra of the sugar ligand and the corresponding AuNP-GCs revealed that both hydroxyl groups on sugar moieties and aromatic protons enhanced the stability of AuNP-GCs. The findings showed that the chemistry and concentration of sugar ligands played a critical role in obtaining the desired size, shape, and optical properties.

show abstract

Nano-carbohydrates: Synthesis and application in genetics, biotechnology, and medicine

Cited by 15 publications

References 172 publications

Recent Advances in the Chemistry of Glycoconjugate Amphiphiles

Recent Advances in the Chemistry of Glycoconjugate Amphiphiles

The Use of Nanobiotechnology in Immunology and Vaccination

Greener One-Pot Synthesis of Gold Nanoparticle Glycoconjugates Using Functionalized Sugars

Contact Info

Product

Resources

About