Nano-carrier based drug delivery systems for sustained antimicrobial agent release from orthopaedic cementous material

Abstract

Total joint replacement (TJR), such as hip and knee replacement, is a popular procedure worldwide. Prosthetic joint infections (PJI) after this procedure have been widely reported, where treatment of such infections is complex with high cost and prolonged hospital stay. In cemented arthroplasties, the use of antibiotic loaded bone cement (ALBC) is a standard practice for the prophylaxis and treatment of PJI. Recently, the development of bacterial resistance by pathogenic microorganisms against most commonly used antibiotics increased the interest in alternative approaches for antimicrobial delivery systems such as nanotechnology. This review summarizes the efforts made to improve the antimicrobial properties of PMMA bone cements using nanotechnology based antibiotic and non-antibiotic delivery systems to overcome drawbacks of ALBC in the prophylaxis and treatment of PJIs after hip and knee replacement.

Hesperidin: synthesis and characterization of bioflavonoid complex

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Synthesis of CuS and ZnO/Zn(OH)2 nanoparticles and their evaluation for in vitro antibacterial and antifungal activities

“…Microbial infections are a growing problem in contemporary medicine, and the use of antibiotics is common across the world. Antimicrobials are among the most commonly purchased drugs worldwide . Health problems demand a novel class of effective antimicrobial compounds to be more resistant against pathogenic microorganisms than the current antibiotics .…”

Self‐healing biomaterials: The next generation is nano

“…Like their counterparts in the dental resin area, nanotechnology is bone cements has focused a great deal of attention on combating infections and nanoscale fillers that augment the mechanical properties of the cements (Al Thaher, Perni, & Prokopovich, 2017;Hesaraki, 2016;Sanz-Ruiz et al, 2018;Shadjou & Hasanzadeh, 2016;T. Wu et al, 2018).…”