Nano composite System based on ZnO-functionalized Graphene Oxide Nanosheets for Determination of Cabergoline

Abstract

In this paper we report an electrochemical sensor based on ZnO-functionalized graphene oxide nanocomposite (ZnO-GO) for the sensitive determination of the cabergoline. Cabergoline electrochemical behaviors were investigated by cyclic voltammetry (CV), chronoamperometry (CHA) and differential pulse voltammetry (DPV). The modified electrode shows electrocatalytic activity toward cabergoline oxidation in phosphate buffer solution (PBS) (pH 7.0) with a reduction of the overpotential of about 180 mV and an increase in peak current. The DPV data showed that the obtained anodic peak currents were linearly dependent on the cabergoline concentrations in the range of 1.0-200.0 μM, with the detection limit of 0.45 μM. The prepared electrode was successfully applied for the determination of cabergoline in real samples.

Graphene-based Nanomaterials in Fighting the Most Challenging Viruses and Immunogenic Disorders

“…Cabergoline, which is utilized in the development phase of PD therapy, is increasingly being viewed as a viable alternative for providing continuous dopaminergic neuron stimulation in PD patients due to its extended half life. 165−167 A sensitive measurement of cabergoline using a ZnOfunctionalized GO-based electrochemically driven sensor was reported by Beitollahi et al 165 CV, DPV, and CA were used to study the electrochemical behavior of cabergoline. For the modified electrode, electrocatalytic activity in PBS (pH 7.0) toward cabergoline oxidation was observed, and a ∼180 mV decrease in overpotential and rising peak current were observed.…”

“…Cabergoline (1-[(6-allelylergolin-8 beta-yl)­carbonyl]-1-[3 (dimethylamino)­propyl]-3-ethyl-urea), a derivative of ergot alkaloid, is a promising agonist of D2 DA receptors. Cabergoline, which is utilized in the development phase of PD therapy, is increasingly being viewed as a viable alternative for providing continuous dopaminergic neuron stimulation in PD patients due to its extended half life. − …”

“…A sensitive measurement of cabergoline using a ZnO-functionalized GO-based electrochemically driven sensor was reported by Beitollahi et al CV, DPV, and CA were used to study the electrochemical behavior of cabergoline. For the modified electrode, electrocatalytic activity in PBS (pH 7.0) toward cabergoline oxidation was observed, and a ∼180 mV decrease in overpotential and rising peak current were observed.…”

Copper oxide, ionic liquid and Mn(III) Salen modified carbon paste electrode as selective electrochemical sensor for determination of droxidopa in the presence of carbidopa

“…Compared with other reported analytical methods, electrochemical methods possess the advantages such as, reliability, simple operation, capability of miniaturization, being portable, fast response, high sensitivity, excellent selectivity, excellent stability, and low cost. In addition, electrochemical methods provide a practical tool for online or field monitoring [13][14][15][16][17][18][19][20][21][22][23][24][25][26][27]. However, a main disadvantage is that droxidopa and carbidopa are oxidized at nearly same potential with poor sensitivity at unmodified usual electrodes.…”