Nano-curcumin prepared via supercritical: Improved anti-bacterial, anti-oxidant and anti-cancer efficacy

Xie, Maobin; Fan, Dejun; Zhao, Zheng; Li, Zhi; Li, Gang; Chen, Yufeng; He, Xiaowen; Chen, Ai-Zheng; Li, Jiashen; Lin, Xiaofen; Mao, Zhi; Li, Yang; Lan, Ping

doi:10.1016/j.ijpharm.2015.11.016

Cited by 99 publications

(52 citation statements)

References 31 publications

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“…For particle size and size distribution, the SEM images were analyzed with Nano Measurer software and about 500 particles were measured. 9,13 Molecular structure change was tested using Fourier-transform infrared spectroscopy (FTIR, 1720 spectrophotometer; PerkinElmer, Waltham, MA, USA). Preparation details are provided in the Supplementary material.…”

Section: Physicochemical Characterizationmentioning

confidence: 99%

“…9,13 Briefly, 10 mL PBS solution (pH 7.4) was added to dry CM-SF NPs and original CM (10 mg) powders and the solution was kept under mild agitation (60 rpm). Insoluble residues were filtered after 1 hour, and then the concentration of the samples was detected at 410 nm using ultraviolet spectrometry for calculating solubility ( Figure S2).…”

Section: Solubility Testmentioning

confidence: 99%

“…Also, the CM NPs obtained showed effective biomedical functions. 13 In order to control drug release, biomaterials are introduced to prepare polymeric nanoplatfoms. [14][15][16] However, synthetic polymers may induce biocompatibility concerns.…”

mentioning

confidence: 99%

“…Procedures were based on our previous studies. 13,22 First, 5×10 4 HCT116 cells were seeded onto coverslips in 24-well plates for cell attachment. Then, cells were treated with samples for 0.5 and 6 hours.…”

mentioning

confidence: 99%

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Supercritical carbon dioxide-developed silk fibroin nanoplatform for smart colon cancer therapy

Xie¹,

Fan²,

Li³

et al. 2017

IJN

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Purpose To deliver insoluble natural compounds into colon cancer cells in a controlled fashion. Materials and methods Curcumin (CM)–silk fibroin (SF) nanoparticles (NPs) were prepared by solution-enhanced dispersion by supercritical CO 2 (SEDS) (20 MPa pressure, 1:2 CM:SF ratio, 1% concentration), and their physicochemical properties, intracellular uptake efficiency, in vitro anticancer effect, toxicity, and mechanisms were evaluated and analyzed. Results CM-SF NPs (<100 nm) with controllable particle size were prepared by SEDS. CM-SF NPs had a time-dependent intracellular uptake ability, which led to an improved inhibition effect on colon cancer cells. Interestingly, the anticancer effect of CM-SF NPs was improved, while the side effect on normal human colon mucosal epithelial cells was reduced by a concentration of ~10 μg/mL. The anticancer mechanism involves cell-cycle arrest in the G 0 /G 1 and G 2 /M phases in association with inducing apoptotic cells. Conclusion The natural compound-loaded SF nanoplatform prepared by SEDS indicates promising colon cancer-therapy potential.

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Section: Physicochemical Characterizationmentioning

confidence: 99%

Section: Solubility Testmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Supercritical carbon dioxide-developed silk fibroin nanoplatform for smart colon cancer therapy

Xie¹,

Fan²,

Li³

et al. 2017

IJN

Self Cite

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“…Recent studies show that curcumin is currently used in dietary spice, foods, textile coloring and medicines due to its beneficial properties, such as anti-inflammatory, anti-bacterial, antifungal, antimicrobial, anti-carcinogenic activities, also contributing to the treat multiple myeloma, Alzheimer's, psoriasis, myelodysplastic syndrome and anti-human immunodeficiency virus (Anti-HIV) cycle replication. Because of the curcumin benefits, there is a great interest in developing new technology to extract such compounds with high purity [4][5][6].…”

Section: Introductionmentioning

confidence: 99%

Comparison of Conventional and Ultrasound Assisted Supercritical Carbon Dioxide Extraction of Curcumin from Turmeric (Curcuma longa L.)

Chhouk¹,

Wahyudiono²,

Kanda³

et al. 2017

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Abstract. Recently, ultrasound assisted supercritical fluid is used for extraction the valuable compounds from a number of plant materials as an alternative to conventional method because it can enhance the extraction rate and yield. Curcumin is an important component of turmeric (Curcuma longa L.) with many useful functions to human health. The objective of this study is using ultrasonic assisted supercritical carbon dioxide (USC-CO2) to extract curcumin from turmeric and compared to conventional method. The effect of operating conditions on extraction, including temperature (40-60 o C), pressure (15-25 MPa), extraction time (30-120 min), CO2 flow rate (2-4 mL/min) and percentage of cosolvent (10-20% v/v) were also studied. The result shows that the high extraction yield of 7.17% w/w and curcumin content of 1.69% w/w were achieved at temperature of 50 o C, pressure of 25 MPa, extraction time of 90 min, CO2 flow rate of 3 mL/min with 10% cosolvent. Compared to conventional method, USC-CO2 could provide higher curcumin content in extraction yield in a shorter extraction time. Scanning electron microscopy (SEM), thermal gravity (TG), and fourier transform infrared spectroscopy (FTIR) was used to analyse turmeric undergoing USC-CO2 and conventional extraction and showed that ultrasound could break down the cell walls and remove some functional groups from plant materials, resulting an increase the selectivity of compounds in extraction yield.

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Supercritical Fluid Technology: An Emphasis on Drug Delivery and Related Biomedical Applications

Kankala

Zhang

Wang

et al. 2017

Adv Healthcare Materials

233

184

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During the past few decades, supercritical fluid (SCF) has emerged as an effective alternative for many traditional pharmaceutical manufacturing processes. Operating active pharmaceutical ingredients (APIs) alone or in combination with various biodegradable polymeric carriers in high-pressure conditions provides enhanced features with respect to their physical properties such as bioavailability enhancement, is of relevance to the application of SCF in the pharmaceutical industry. Herein, recent advances in drug delivery systems manufactured using the SCF technology are reviewed. We provide a brief description of the history, principle, and various preparation methods involved in the SCF technology. Next, we aim to give a brief overview, which provides an emphasis and discussion of recent reports using supercritical carbon dioxide (SC-CO2) for fabrication of polymeric carriers, for applications in areas related to drug delivery, tissue engineering, bio-imaging, and other biomedical applications. We finally summarize with perspectives.

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Nano-curcumin prepared via supercritical: Improved anti-bacterial, anti-oxidant and anti-cancer efficacy

Cited by 99 publications

References 31 publications

Supercritical carbon dioxide-developed silk fibroin nanoplatform for smart colon cancer therapy

Supercritical carbon dioxide-developed silk fibroin nanoplatform for smart colon cancer therapy

Comparison of Conventional and Ultrasound Assisted Supercritical Carbon Dioxide Extraction of Curcumin from Turmeric (Curcuma longa L.)

Supercritical Fluid Technology: An Emphasis on Drug Delivery and Related Biomedical Applications

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