Nano Drug-Delivery Systems for Management of AIDS: Liposomes, Dendrimers, Gold and Silver Nanoparticles

Abstract

AIDS causes increasing mortality every year. With advancements in nanomedicine, different nanomaterials (NMs) have been applied to treat AIDS and overcome its limitations. Among different NMs, nanoparticles (NPs) can act as nanocarriers due to their enhanced solubility, sustained release, targeting abilities and facilitation of drug dose reductions. This review discusses recent advancements in therapeutics for AIDS/HIV using various NMs, mainly focused on three classifications: polymeric, liposomal and inorganic NMs. Polymeric dendrimers, polyethylenimine-NPs, poly(lactic-co-glycolic acid)-NPs, chitosan and the use of liposomal-based delivery systems and inorganic NPs, including gold and silver NPs, are explored. Recent advances, current challenges and future perspectives on the use of these NMs for better management of HIV/AIDS are also discussed.

Hydrogel nanoparticles as new drug delivery system for CNS disorders

“…The ability to non‐invasively circumvent the BBB and encapsulate the appropriate medicine are just two of the numerous benefits that nano‐enabled DDSs offer over traditional pharmaceuticals and DDSs, making them perfect for the treatment of CNS illnesses [2,59] . Tiny particles, nanocapsules, dendrimers, nanospheres, nanocomposite hydrogels, and liposomal drug delivery vehicles are some of the drug delivery methods used in nanomedicine [68] . Dendrimers are intricately branched, three‐dimensional macromolecules that exhibit a limited range of sizes and little variability.…”

“…[2,59] Tiny particles, nanocapsules, dendrimers, nanospheres, nanocomposite hydrogels, and liposomal drug delivery vehicles are some of the drug delivery methods used in nanomedicine. [68] Dendrimers are intricately branched, threedimensional macromolecules that exhibit a limited range of sizes and little variability. They are used in medication delivery systems because of their uniform size distribution and exceptional transport characteristics.…”

Nanoparticle-Mediated Immunotherapy in Triple-Negative Breast Cancer

“… 119 Compared to LNPs, polymer NPs have fewer components but a more flexible structure. 117 Given their abilities of enhancing drug solubility and stability or rigidity, achieving sustained drug release and improving physiochemical drug features, 120 , 121 the implementaion of them in new immune treatment strategies of TNBC represents one of the most promising fields of development inbiochemical and pharmaceutical science.…”