Nano-encapsulations liberated from barley protein microparticles for oral delivery of bioactive compounds

A novel process for microencapsulation of fish oil with barley protein

“…According to our previous work, well suspended solid microcapsules were created from barley protein pre-mixed emulsions after a microfluidizer treatment (Wang et al, 2011). This phenomenon is different from that observed for globular proteins (whey and soy protein) stabilized emulsion systems, where the emulsions only form soluble aggregates via surface hydrophobic interactions after high pressure treatment (Beaulieu et al, 2002;Floury et al, 2002).…”

“…Both hordein and glutelin fractions are highly hydrophobic. Recent research revealed their excellent emulsifying and film-forming properties (Wang et al, 2010) and demonstrated that emulsifying-stabilization process can prepare microcapsules from barley protein (Wang et al, 2011). Well suspended solid particles, rather than a soluble emulsion complex, were obtained after passing the pre-mixed solution through a microfluidizer system.…”

Potentially bioactive and caffeine-loaded peptidic sub-micron and nanoscalar particles

“…This suggests the preserved integrity of particles over 6 h. In a study on bovine serum albumin gel beadlets obtained through transglutaminase-induced cross-linking, Gan et al (2009) observed that cross-linking of beadlets decreased the rate of release of caffeine into simulated gastric tract. In the simulated gastric fluid with pepsin, caffeine slowly released from the cross-linked sample so that less than 20% of the entrapped caffeine was detected in the release medium after 2 h. This corresponds to the sufficient time for foods and drugs to pass through the stomach into the small intestine where they are absorbed (Wang, Tian, & Chen, 2011). Even after 6 h digestion with pepsin, only $28% of caffeine was released (Fig.…”

Edible Bio-Based Nanostructures: Delivery, Absorption and Potential Toxicity

“…Depending on bioactive compound characteristics, it is possible to obtain different release mechanisms during digestion process. Hydrophilic compounds release from a protein matrix by diffusion, whereas lipophilic compounds are released mainly by enzymatic degradation of the protein matrix in the GI tract [170]. Examples of bioactive compounds efficiently incorporated into bio-based nanohydrogels, techniques used in their encapsulation and their main limitations are summarized in Table 1.…”