Nano-Engineered Biomaterials for Tissue Regeneration: What Has Been Achieved So Far?

McLaughlin, Sarah; Podrebarac, James; Ruel, Marc; Suuronen, Erik J.; McNeill, Brian; Alarcon, Emilio I.

doi:10.3389/fmats.2016.00027

Cited by 49 publications

(31 citation statements)

References 235 publications

(313 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Nanoparticles have become significant in the regenerative medicine field in the last two decades (McLaughlin et al, 2016). Many biological processes happen at through mechanisms that fundamentally act at the nanometer scale.…”

Section: Nanoparticle-based Wound Therapiesmentioning

confidence: 99%

Biomaterials and Nanotherapeutics for Enhancing Skin Wound Healing

Baker

2016

Front. Bioeng. Biotechnol.

254

196

View full text Add to dashboard Cite

Wound healing is an intricate process that requires complex coordination between many cell types and an appropriate extracellular microenvironment. Chronic wounds often suffer from high protease activity, persistent infection, excess inflammation, and hypoxia. While there has been intense investigation to find new methods to improve cutaneous wound care, the management of chronic wounds, burns, and skin wound infection remain challenging clinical problems. Ideally, advanced wound dressings can provide enhanced healing and bridge the gaps in the healing processes that prevent chronic wounds from healing. These technologies have great potential for improving outcomes in patients with poorly healing wounds but face significant barriers in addressing the heterogeneity and clinical complexity of chronic or severe wounds. Active wound dressings aim to enhance the natural healing process and work to counter many aspects that plague poorly healing wounds, including excessive inflammation, ischemia, scarring, and wound infection. This review paper discusses recent advances in the development of biomaterials and nanoparticle therapeutics to enhance wound healing. In particular, this review focuses on the novel cutaneous wound treatments that have undergone significant preclinical development or are currently used in clinical practice.

show abstract

Section: Nanoparticle-based Wound Therapiesmentioning

confidence: 99%

Biomaterials and Nanotherapeutics for Enhancing Skin Wound Healing

Baker

2016

Front. Bioeng. Biotechnol.

254

196

View full text Add to dashboard Cite

show abstract

“…The collagen is the main constituent of extra cellular tissue, which is responsible for support and strength [22]. Nanoparticles have become significant in the regenerative medicine field in the last two decades [23]. Many biological processes happen at through mechanisms that fundamentally act at the nanometer scale.…”

Section: Discussionmentioning

confidence: 99%

Effects of Aloe Vera and Chitosan Nanoparticle Thin-Film Membranes on Wound Healing in Full Thickness Infected Wounds with Methicillin Resistant Staphylococcus Aureus

Ranjbar

Yousefi

2018

BEAT

View full text Add to dashboard Cite

Objective: To assess effect of Aleo vera with chitosan nanoparticle biofilm on wound healing in full thickness infected wounds with antibiotic resistant gram positive bacteria. Method: Thirty rats were randomized into five groups of six rats each. Group I: Animals with uninfected wounds treated with 0.9% saline solution. Group II: Animals with infected wounds treated with saline. Group III: Animals with infected wounds were dressed with chitosan nanoparticle thin-film membranes. Group IV: Animals with infected wounds were treated topically with Aloe vera and Group V: Animals with infected wounds were treated topically with Aloe vera and dressed with chitosan nanoparticle thin-film membranes. Wound size was measured on 6, 9, 12, 15, 18 and 21days after surgery. Results: Microbiology, reduction in wound area and hydroxyproline contents indicated that there was significant difference (p<0.05) between group V and other groups. Quantitative histological studies and mean rank of the qualitative studies demonstrated that there was significant difference (p<0.05) between group V and other groups. Conclusion: The Aloe vera with chitosan nanoparticle thin-film membranes had a reproducible wound healing potential and hereby justified its use in practice.

show abstract

“…These scaffolds are able to control cell attachment, growth, and differentiation as well as promote the regeneration of various tissues. 22 Therefore, NMs are increasingly becoming key components in tissue-engineered biomaterials for cardiac and vascular regeneration in patients with MI, heart failure, or coronary artery disease.…”

Section: Nanoengineered Electroconductive Biomaterials 121mentioning

confidence: 99%

“…33 In recent years, graphene has received much interest in the design of engineered cardiac patches to regenerate a functional myocardium following infarction due to their high conductivity. 22 In this regard, the success of these patches has been limited by the challenge of creating engineered tissues that can reestablish the structure and function of the native cardiac tissue across different size scales. 34 CNTs incorporated into scaffolds have also demonstrated a positive effect on the regeneration of cardiac tissue due to their conductivity and nanostructures.…”

Section: Fig 1 Schematic Illustration Of Different Electro-mentioning

confidence: 99%

Electroconductive Nanobiomaterials for Tissue Engineering and Regenerative Medicine

et al. 2020

View full text Add to dashboard Cite

Regenerative medicine aims to engineer tissue constructs that can recapitulate the functional and structural properties of native organs. Most novel regenerative therapies are based on the recreation of a three-dimensional environment that can provide essential guidance for cell organization, survival, and function, which leads to adequate tissue growth. The primary motivation in the use of conductive nanomaterials in tissue engineering has been to develop biomimetic scaffolds to recapitulate the electrical properties of the natural extracellular matrix, something often overlooked in numerous tissue engineering materials to date. In this review article, we focus on the use of electroconductive nanobiomaterials for different biomedical applications, particularly, very recent advancements for cardiovascular, neural, bone, and muscle tissue regeneration. Moreover, this review highlights how electroconductive nanobiomaterials can facilitate cell to cell crosstalk (i.e., for cell growth, migration, proliferation, and differentiation) in different tissues. Thoughts on what the field needs for future growth are also provided.

show abstract

Nano-Engineered Biomaterials for Tissue Regeneration: What Has Been Achieved So Far?

Cited by 49 publications

References 235 publications

Biomaterials and Nanotherapeutics for Enhancing Skin Wound Healing

Biomaterials and Nanotherapeutics for Enhancing Skin Wound Healing

Effects of Aloe Vera and Chitosan Nanoparticle Thin-Film Membranes on Wound Healing in Full Thickness Infected Wounds with Methicillin Resistant Staphylococcus Aureus

Electroconductive Nanobiomaterials for Tissue Engineering and Regenerative Medicine

Contact Info

Product

Resources

About