Nano-engineering chitosan particles to sustain the release of promethazine from orodispersables

Elwerfalli, Arwa Matoug; Al-Kinani, Ali A.; Alany, Raid G.; ElShaer, Amr

doi:10.1016/j.carbpol.2015.05.064

Cited by 22 publications

(24 citation statements)

References 45 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Pentasodium tripolyphosphate (TPP) anions were used to prepare chitosan nanoparticles according to the ionotropic gelation of chitosan . Chitosan powder (Sigma‐Aldrich) was dissolved in 1% acetic acid aqueous solutions.…”

Section: Methodsmentioning

confidence: 99%

Evaluation of the preventive and therapeutic effects of a recombinant vector co‐expressing prostate‐specific stem cell antigen and Clostridium perfringens enterotoxin on prostate cancer in rats

Abedi

Doosti

Jami

2019

Biotechnology Progress

View full text Add to dashboard Cite

The effects of Clostridium perfringens enterotoxin (CPE) and prostate stem cell antigen (PSCA) on cancer prevention or treatment have been previously studied separately. For the first time, here we have elaborated a recombinant vector to co‐express and study the cumulative effects of both of these factors on prostate cancer (PCa) in an animal model. The recombinant pBudCE4.1‐cpe‐PSCA vector was constructed in large scale. Rats were vaccinated by vector or vector plus chitosan nanoparticles before or after induction of PCa (preventive or therapeutic studies) by N‐methyl N‐nitrosurea and testosterone. Prostate tumors were weighed and histologically examined. Tumors and infusion site tissues as well as blood samples of all rats were collected and assessed by serological and molecular tests. We showed that vaccination with vector (along with or without nanoparticles) led to lower PCa incidence and tumor weight. The L‐1β, IL6, and TNF‐α serum levels and their gene expression accompanied by C‐CAM1 gene expression in vaccinated groups were significantly higher than controls while no difference was seen in CK20 expression among all groups. Our findings showed that vector could effectively stimulate the immune system of rats to either prevent or suppress the PCa tumors. Adding chitosan nanoparticles did not affect the results significantly.

show abstract

Section: Methodsmentioning

confidence: 99%

Evaluation of the preventive and therapeutic effects of a recombinant vector co‐expressing prostate‐specific stem cell antigen and Clostridium perfringens enterotoxin on prostate cancer in rats

Abedi

Doosti

Jami

2019

Biotechnology Progress

View full text Add to dashboard Cite

show abstract

“…Similar to pellets and microcapsules, there should be rapid disintegration of the tablet upon oral administration causing the release of individual drug-loaded nanocapsules, which should distribute readily along the gastrointestinal tract with a sustained release of the drug substance from each nanocapsule. Nanocapsules are fine particles and are much smaller compared to microcapsules and pellets; therefore, they tend to have greater bioavailability, better distribution in the gastrointestinal tract, and a reduced risk of local irritation and toxicity [72]. Friedrich et al prepared drug-loaded polymeric nanocapsules containing dexamethasone, which is a corticosteroid used to reduce inflammation, as the model drug.…”

Section: Sustained-release Tablets Of Coated Nanocapsulesmentioning

confidence: 99%

“…These were PEG, PVP, and polyethylacrylic acid (PEAA). Conventional ODTs containing PMZ, and not consisting of polymer-coated nanoparticles were used as a control as well as non-coated chitosan PMZ-loaded nanoparticles to compare the in vitro drug release with the polymer-coated CS nanoencapsulated SR-ODTs [72]. Dissolution studies revealed that ODTs containing polymer-coated chitosan nanoparticles could sustain the drug release, and therefore exhibited a much slower release of the drug over the 24-h period investigated compared to the conventional PMZ tablets and the uncoated chitosan nanoparticle tablets.…”

Section: Sustained-release Tablets Of Coated Nanocapsulesmentioning

confidence: 99%

“…Therefore, this indicated that the polymeric coating remained intact during compression, allowing for a slow release of PMZ over an extended period. However, this was not the case for tablets consisting of PEAA-coated nanoparticles, in which 45% of drug was released within 2 h, causing a burst effect [72].…”

Section: Sustained-release Tablets Of Coated Nanocapsulesmentioning

confidence: 99%

See 1 more Smart Citation

Oral Modified Release Multiple-Unit Particulate Systems: Compressed Pellets, Microparticles and Nanoparticles

et al. 2018

Self Cite

View full text Add to dashboard Cite

Oral modified-release multiparticulate dosage forms, which are also referred to as oral multiple-unit particulate systems, are becoming increasingly popular for oral drug delivery applications. The compaction of polymer-coated multiparticulates into tablets to produce a sustained-release dosage form is preferred over hard gelatin capsules. Moreover, multiparticulate tablets are a promising solution to chronic conditions, patients’ adherence, and swallowing difficulties if incorporated into orodispersible matrices. Nonetheless, the compaction of multiparticulates often damages the functional polymer coat, which results in a rapid release of the drug substance and the subsequent loss of sustained-release properties. This review brings to the forefront key formulation variables that are likely to influence the compaction of coated multiparticulates into sustained-release tablets. It focusses on the tabletting of coated drug-loaded pellets, microparticles, and nanoparticles with a designated section on each. Furthermore, it explores the various approaches that are used to evaluate the compaction behaviour of particulate systems.

show abstract

“…Many approaches such as microencapsulation, nanoparticles, ion exchange resins and stimuli-responsive polymers have been adapted to control the drug release across ODTs (ELWERFALLI et al, 2015a). ELWERFALLI et al (2015b) studied chitosan particles to sustain the release of promethazine from orodispersables. Chitosan nanoparticles were prepared using ionotropic gelation and further coated.…”

Section: Sustained Release Orally Disintegrating Tablets (Sr-odts)mentioning

confidence: 99%

The application prospects and development trends of orally disintegrating tablets to dogs

2017

Cienc. Rural

View full text Add to dashboard Cite

Orally disintegrating tablets (ODTs) disintegrate rapidly in the mouth in seconds when placed at the tongue. The introduction of ODTs for dogs can address many needs, ranging from convenient dosing for dogs with dysphagia to extending life cycle of drugs. Now, different technologies are widely combined for developing ODTs. The combination makes ODTs have more properties, obtaining orally disintegrating sustained release tablets or orally disintegrating enteric tablets or enhancing the dissolution rate and bioavailability of poorly water-soluble drugs and so on. The aim of this article is to give a comprehensive prospect to the application of ODTs to dogs, including ideal properties of drugs, indications of ODTs, considerations in developing ODTs and development trends of ODTs for dogs.

show abstract

Nano-engineering chitosan particles to sustain the release of promethazine from orodispersables

Cited by 22 publications

References 45 publications

Evaluation of the preventive and therapeutic effects of a recombinant vector co‐expressing prostate‐specific stem cell antigen and Clostridium perfringens enterotoxin on prostate cancer in rats

Evaluation of the preventive and therapeutic effects of a recombinant vector co‐expressing prostate‐specific stem cell antigen and Clostridium perfringens enterotoxin on prostate cancer in rats

Oral Modified Release Multiple-Unit Particulate Systems: Compressed Pellets, Microparticles and Nanoparticles

The application prospects and development trends of orally disintegrating tablets to dogs

Contact Info

Product

Resources

About