Nano-fiber scaffold electrodes based on PEDOT for cell stimulation

Bolin, Maria; Svennersten, Karl; Wang, Xiangjun; Chronakis, Ioannis S.; Richter‐Dahlfors, Agneta; Jager, Edwin; Berggren, Magnus

doi:10.1016/j.snb.2009.04.062

Cited by 119 publications

(95 citation statements)

References 30 publications

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“…Their results showed that PEDOT films exhibit very low intrinsic cytotoxicity and that their inflammatory response upon implantation was good, making them ideal for biosensing and bioengineering applications. Bolin et al (2009) fabricated electrospun poly(ethylene terephthalate) (PET) nanofibres and coated PET nanofibres with PEDOT doped with tosylate, using the vapour phase polymerization method. Their results showed excellent adhesion and proliferation of neuronal cells on PEDOT-coated PET nanofibres.…”

Section: Poly (3 4-ethylenedioxythiophene)mentioning

confidence: 99%

Application of conductive polymers, scaffolds and electrical stimulation for nerve tissue engineering

Ghasemi‐Mobarakeh¹,

Prabhakaran²,

Morshed³

et al. 2011

J Tissue Eng Regen Med

613

389

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Among the numerous attempts to integrate tissue engineering concepts into strategies to repair nearly all parts of the body, neuronal repair stands out. This is partially due to the complexity of the nervous anatomical system, its functioning and the inefficiency of conventional repair approaches, which are based on single components of either biomaterials or cells alone. Electrical stimulation has been shown to enhance the nerve regeneration process and this consequently makes the use of electrically conductive polymers very attractive for the construction of scaffolds for nerve tissue engineering. In this review, by taking into consideration the electrical properties of nerve cells and the effect of electrical stimulation on nerve cells, we discuss the most commonly utilized conductive polymers, polypyrrole (PPy) and polyaniline (PANI), along with their design and modifications, thus making them suitable scaffolds for nerve tissue engineering. Other electrospun, composite, conductive scaffolds, such as PANI/gelatin and PPy/poly(ε-caprolactone), with or without electrical stimulation, are also discussed. Different procedures of electrical stimulation which have been used in tissue engineering, with examples on their specific applications in tissue engineering, are also discussed.

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Section: Poly (3 4-ethylenedioxythiophene)mentioning

confidence: 99%

Application of conductive polymers, scaffolds and electrical stimulation for nerve tissue engineering

Ghasemi‐Mobarakeh¹,

Prabhakaran²,

Morshed³

et al. 2011

J Tissue Eng Regen Med

613

389

View full text Add to dashboard Cite

show abstract

“…PEDOT, poly (3,4-ethylenedioxythiophene) [1][2][3][4], is a conductive polymer [5] that can be used in many different applications such as antistatic coating of polymers and glass, high conductive coatings, organic LED-(OLED) displays [6], nano-fiber electrodes for cell stimulation [7], solar cells, cathode material in electrolytic capacitors, printing wiring boards [8], textile fibres with colour changing properties [9], transparent electrodes for thick-film electroluminescence [10], source gate and drain in the rapidly developing organic semi-conductors field [11].…”

Section: Introductionmentioning

confidence: 99%

The electronic structure and reflectivity of PEDOT:PSS from density functional theory

et al. 2011

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The geometric and electronic structure of condensed phase organic conducting polymer PEDOT:PSS blends has been investigated by periodic density functional theory (DFT) calculations with a generalized-gradient approximation (GGA) functional, and a plane wave basis set. The influence of the degree of doping of the PEDOT polymer on structural and optical parameters such as the reflectivity, absorbance, conductivity, dielectric function, refractive index and the energy-loss function is studied. A flip from the benzoid to the quinoid structure is observed in the calculations when the neutral PEDOT is doped by negatively charged PSS. Also the optical properties are affected by the doping. In particular, the reflectivity was found to be very sensitive to the degree of doping, where higher doping implies higher reflectivity. The reflectivity is highly anisotropic, with the dominant contribution stemming from the direction parallel to the PEDOT polymer chain.

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“…These conductive scaffolds were used to electrically stimulate Ca 2+ signaling [36,95] in SH-SY5Y nueroblastoma cells. Results showed that the combination of ES with highly porous and permeable 3D structures provided additional functionality to stimulate cells or record cell signaling [96] .…”

Section: Cps Nanofibres Scaffoldsmentioning

confidence: 99%

Bio‐Interface of Conducting Polymer‐Based Materials for Neuroregeneration

Weng

Diao

et al. 2015

Adv Materials Inter

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Nerve system diseases like Parkinson's disease, Huntington's disease, Alzheimer's disease, etc. seriously affect thousands of patients' lives every year, making them suffer from pains and inconvenience. Recently, biointerfaces between neural cells/tissues and polymer based biomaterials attracted worldwide attention due to the ability of polymer based biomaterials to serve as nerve conduits, drug carriers and neurites guidance platform in neuroregeneration. The role that bio-interface played and the way it interacted with neural tissues and cells have been thoroughly investigated by the researchers. In this paper we mainly focus on reviewing the bio-interface between nerve tissues/cells and advanced functional biocompatible polymers, such as conducting polymers and advanced carbon composite materials. These advanced polymers can provide combined interfacial stimulations including interfacial external neurotrophic factors (NTFs) delivery, electrical stimulation, surface guidance and molecules decoration to lesion cells and tissues to promote neuroregeneration in vitro and in vivo, and have contributed greatly to nerve diseases therapy. At the end of this review, the criteria of polymer based biomaterials utilized in neuroregeneration are summarized and the perspectives for future development of bio-interfaces are also discussed. Nerve system diseases like Parkinson's disease, Huntington's disease and Alzheimer's disease etc. seriously affect thousands of patients' lives every year, making the patients suffer from pains and inconvenience brought about by these diseases. Recently, bio-interface between neural cells/tissues and polymer based biomaterials attracted worldwide attention due to the ability of polymer based biomaterials to serve as nerve conduits, drug carrier and neurites guidance platform in neuroregeneration. The role that bio-interface played and the way it interacted with neural tissues and cells have been thoroughly investigated by the researchers.In this paper we mainly focus on reviewing bio-interface between nerve tissues/cells and advanced functional biocompatible polymers, such as conducting polymers and advanced carbon composites materials.. These advanced polymers can provide combined interfacial stimulations including interfacial NTFs delivery, electrical stimulation, surface guidance and molecules decoration to lesion cells and tissues to promote neuroregeneration in vitro and in vivo, and have contributed greatly to nerve diseases therapy. At the end of this review, the criteria of polymer based biomaterials utilized in neuroregeneration are summarized and the perspectives for future development of bio-interfaces are also discussed.

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Nano-fiber scaffold electrodes based on PEDOT for cell stimulation

Cited by 119 publications

References 30 publications

Application of conductive polymers, scaffolds and electrical stimulation for nerve tissue engineering

Application of conductive polymers, scaffolds and electrical stimulation for nerve tissue engineering

The electronic structure and reflectivity of PEDOT:PSS from density functional theory

Bio‐Interface of Conducting Polymer‐Based Materials for Neuroregeneration

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