Nano-formulated delivery of active ingredients from traditional Chinese herbal medicines for cancer immunotherapy

Shang, Qi; Liu, Wandong; Leslie, Faith; Yang, Jiapei; Guo, Mingmei; Sun, Mingjiao; Zhang, Guangji; Zhang, Qiang; Wang, Feihu

doi:10.1016/j.apsb.2023.12.008

Acta Pharmaceutica Sinica B

2024

DOI: 10.1016/j.apsb.2023.12.008

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Nano-formulated delivery of active ingredients from traditional Chinese herbal medicines for cancer immunotherapy

Qi Shang,

Wandong Liu,

Faith Leslie

et al.

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Cited by 3 publications

References 166 publications

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Research advances on signaling pathways regulating the polarization of tumor-associated macrophages in lung cancer microenvironment

Li,

Yuan,

et al. 2024

Front. Immunol.

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Lung cancer (LC) is one of the most common cancer worldwide. Tumor-associated macrophages (TAMs) are important component of the tumor microenvironment (TME) and are closely related to the stages of tumor occurrence, development, and metastasis. Macrophages are plastic and can differentiate into different phenotypes and functions under the influence of different signaling pathways in TME. The classically activated (M1-like) and alternatively activated (M2-like) represent the two polarization states of macrophages. M1 macrophages exhibit anti-tumor functions, while M2 macrophages are considered to support tumor cell survival and metastasis. Macrophage polarization involves complex signaling pathways, and blocking or regulating these signaling pathways to enhance macrophages’ anti-tumor effects has become a research hotspot in recent years. At the same time, there have been new discoveries regarding the modulation of TAMs towards an anti-tumor phenotype by synthetic and natural drug components. Nanotechnology can better achieve combination therapy and targeted delivery of drugs, maximizing the efficacy of the drugs while minimizing side effects. Up to now, nanomedicines targeting the delivery of various active substances for reprogramming TAMs have made significant progress. In this review, we primarily provided a comprehensive overview of the signaling crosstalk between TAMs and various cells in the LC microenvironment. Additionally, the latest advancements in novel drugs and nano-based drug delivery systems (NDDSs) that target macrophages were also reviewed. Finally, we discussed the prospects of macrophages as therapeutic targets and the barriers to clinical translation.

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Research advances on signaling pathways regulating the polarization of tumor-associated macrophages in lung cancer microenvironment

Li,

Yuan,

et al. 2024

Front. Immunol.

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Enhancing the Efficacy of Active Pharmaceutical Ingredients in Medicinal Plants through Nanoformulations: A Promising Field

Chen,

Tang,

et al. 2024

Nanomaterials

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This article explores the emerging field of nanomedicine as a drug delivery system, aimed at enhancing the therapeutic efficacy of active pharmaceutical ingredients in medicinal plants. The traditional methods of applying medicinal plants present several limitations, such as low bioavailability, poor solubility, challenges in accurately controlling drug dosage, and inadequate targeting. Nanoformulations represent an innovative approach in drug preparation that employs nanotechnology to produce nanoscale particles or carriers, which are designed to overcome these limitations. Nanoformulations offer distinct advantages, significantly enhancing the solubility and bioavailability of drugs, particularly for the poorly soluble components of medicinal plants. These formulations effectively enhance solubility, thereby facilitating better absorption and utilization by the human body, which in turn improves drug efficacy. Furthermore, nanomedicine enables targeted drug delivery, ensuring precise administration to the lesion site and minimizing side effects on healthy tissues. Additionally, nanoformulations can regulate drug release rates, extend the duration of therapeutic action, and enhance the stability of treatment effects. However, nanoformulations present certain limitations and potential risks; their stability and safety require further investigation, particularly regarding the potential toxicity with long-term use. Nevertheless, nanomaterials demonstrate substantial potential in augmenting the efficacy of active pharmaceutical ingredients in medicinal plants, offering novel approaches and methodologies for their development and application.

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Polyamidoamine Dendrimers: Brain-Targeted Drug Delivery Systems in Glioma Therapy

Yan,

Chen

2024

Polymers

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Glioma is the most common primary intracranial tumor, which is formed by the malignant transformation of glial cells in the brain and spinal cord. It has the characteristics of high incidence, high recurrence rate, high mortality and low cure rate. The treatments for glioma include surgical removal, chemotherapy and radiotherapy. Due to the obstruction of the biological barrier of brain tissue, it is difficult to achieve the desired therapeutic effects. To address the limitations imposed by the brain’s natural barriers and enhance the treatment efficacy, researchers have effectively used brain-targeted drug delivery systems (DDSs) in glioma therapy. Polyamidoamine (PAMAM) dendrimers, as branched macromolecular architectures, represent promising candidates for studies in glioma therapy. This review focuses on PAMAM-based DDSs in the treatment of glioma, highlighting their physicochemical characteristics, structural properties as well as an overview of the toxicity and safety profiles.

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Nano-formulated delivery of active ingredients from traditional Chinese herbal medicines for cancer immunotherapy

Cited by 3 publications

References 166 publications

Research advances on signaling pathways regulating the polarization of tumor-associated macrophages in lung cancer microenvironment

Research advances on signaling pathways regulating the polarization of tumor-associated macrophages in lung cancer microenvironment

Enhancing the Efficacy of Active Pharmaceutical Ingredients in Medicinal Plants through Nanoformulations: A Promising Field

Polyamidoamine Dendrimers: Brain-Targeted Drug Delivery Systems in Glioma Therapy

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