Nano forsterite biocomposites for medical applications: Mechanical properties and bioactivity

Abstract

The aim of the present study was to obtain and to investigate nano forsterite and nano forsterite biocomposites for biomedical application. New self-curing forsterite biocomposites were obtained by mixing nano forsterite powder (5, 15, 30, 50, 70 wt %) with 2,2-bis[4-(2-hydroxy-3-methacryloyloxypropoxy)-phenyl]propane (bis-GMA) and triethyleneglycol dimethacrylate (TEGDMA) monomers. The new nano forsterite biocomposites were investigated for mechanical properties: compressive strength (CS) (143-147.12 MPa), compressive modulus (CM) (1.67-2.75 GPa), diametral tensile strength (DTS) (27.33-31.55 MPa), flexural strength (FS) (59.47-83.20 MPa) and flexural modulus (FM) (2.05-8.60 GPa). Increases of CS, DTS, FS with increasing amount of forsterite were observed up to 50 wt %. The highest CM and FM values were registered for 70 wt % and a direct correlation between the forsterite volume fraction (%) was observed. SEM micrographs revealed the morphology of surface of fractured biocomposites after CS test. XPS indicated that these biocomposites promoted the hydroxyapatite formation on their surface immersed in simulated body fluid (SBF). AFM images showed that the growth of the hydroxyapatite layer occurs with a preferred orientation on the surface of forsterite biocomposites after immersion in SBF. Incorporation of nano forsterite in the polymer matrix (bis-GMA/TEGDMA) did show osteoblast adhesion and proliferation was improved on nano forsterite biocomposites. © 2015 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 104B: 1290-1301, 2016.

Amoxicillin-loaded electrospun nanocomposite membranes for dental applications

“…Although the Ca/P ratio in pure hydroxyapatite is 1.67, the formation of calcium-deficient apatite at Ca/P ratio is in agreement with other studies reporting Ca/P values such as 1.06, 1.27, 1.55, or 1.6. [44][45][46][47][48][49] The chlorine ions detected at the membrane surface may be due to some infiltration from the SBF solution, and could be found in the structure of apatite layer as chlorapatite Ca 10 (PO 4 ) 6 (Cl) 2 .…”

The Effect of Application of Forsterite Nanoparticles in Different Protocols on Permeability of Superficial and Deep Dentin

“…Moreover, Forsterite nanopowder is bioactive and possesses apatite-forming ability. Because the lumen of the dentinal tubules is a calcium-rich environment, there is a strong possibility that HA particles could be deposited inside the tubules (32,35) . This would result in re-mineralization process that promotes a strong and permanent adhesion between the biomaterial and the tooth (36) .…”

Low Crystallinity Nanohydroxyapatite Prepared at Room Temperature

“…TEM images have been recorded with JEOL standard software. Atomic force microscopy (AFM) images were obtained using the AFM JEOL 4210 equipment, operated in tapping mode [32][33][34][35][36][37][38][39][40][41], with standard cantilevers having silicon nitride tips (resonant frequency in the range of 200-300 kHz, spring constant 17.5 N/m). The particles were adsorbed (horizontal adsorption) from their aqueous dispersion for 10 s on glass.…”