Nano-hydroxyapatite as a delivery system: overview and advancements

Munir, Muhammad Usman; Salman, Sajal; Javed, Ibrahim; Bukhari, Syed Nasir Abbas; Ahmad, Naveed; Shad, Naveed Akhter; Aziz, Farooq

doi:10.1080/21691401.2021.2016785

Cited by 70 publications

(36 citation statements)

References 88 publications

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“…The apatite surfaces can be modified (charged to improve the interactions with living cells, particularly the osteoblasts) [ 19 ]. In addition, Ap NPs have already been shown to be valuable nanocarriers for different types of molecules [ 20 ], including nucleic acids [ 21 ], proteins [ 22 ], antibiotics [ 3 ], chemotherapeutics [ 23 , 24 ], fluorophores [ 25 ], and luminescent moieties [ 26 , 27 ]. Among their advantageous properties are high biocompatibility, good biodegradability, high loading capacity with the ability to bind moieties through both surface calcium and phosphate groups by isothermal adsorption.…”

Section: Introductionmentioning

confidence: 99%

Biomimetic Citrate-Coated Luminescent Apatite Nanoplatforms for Diclofenac Delivery in Inflammatory Environments

et al. 2022

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Luminescent nanoparticles are innovative tools for medicine, allowing the imaging of cells and tissues, and, at the same time, carrying and releasing different types of molecules. We explored and compared the loading/release ability of diclofenac (COX-2 antagonist), in both undoped- and luminescent Terbium3+ (Tb3+)-doped citrate-coated carbonated apatite nanoparticles at different temperatures (25, 37, 40 °C) and pHs (7.4, 5.2). The cytocompatibility was evaluated on two osteosarcoma cell lines and primary human osteoblasts. Biological effects of diclofenac-loaded-nanoparticles were monitored in an in vitro osteoblast’s cytokine–induced inflammation model by evaluating COX-2 mRNA expression and production of PGE2. Adsorption isotherms fitted the multilayer Langmuir-Freundlich model. The maximum adsorbed amounts at 37 °C were higher than at 25 °C, and particularly when using the Tb3+ -doped particles. Diclofenac-release efficiencies were higher at pH 5.2, a condition simulating a local inflammation. The luminescence properties of diclofenac-loaded Tb3+ -doped particles were affected by pH, being the relative luminescence intensity higher at pH 5.2 and the luminescence lifetime higher at pH 7.4, but not influenced either by the temperature or by the diclofenac-loaded amount. Both undoped and Tb3+-doped nanoparticles were cytocompatible. In addition, diclofenac release increased COX-2 expression and decreased PGE2 production in an in vitro inflammation model. These findings evidence the potential of these nanoparticles for osteo-localized delivery of anti-inflammatory drugs and the possibility to localize the inflammation, characterized by a decrease in pH, by changes in luminescence.

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Section: Introductionmentioning

confidence: 99%

Biomimetic Citrate-Coated Luminescent Apatite Nanoplatforms for Diclofenac Delivery in Inflammatory Environments

et al. 2022

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“…After extravasation in the tumor tissue, the penetration depth has been chiefly facilitated by the diffusion balance [ 133 ]. Still, the in-vivo penetration of nanoparticles is challenging as the size of NPs influences other aspects such as accumulation and circulation [ 134 , 135 ].…”

Section: Conventional Approaches In Modifying the Tumor Penetrationmentioning

confidence: 99%

Nanomedicine Penetration to Tumor: Challenges, and Advanced Strategies to Tackle This Issue

Munir

2022

Cancers

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Nanomedicine has been under investigation for several years to improve the efficiency of chemotherapeutics, having minimal pharmacological effects clinically. Ineffective tumor penetration is mediated by tumor environments, including limited vascular system, rising cancer cells, higher interstitial pressure, and extra-cellular matrix, among other things. Thus far, numerous methods to increase nanomedicine access to tumors have been described, including the manipulation of tumor micro-environments and the improvement of nanomedicine characteristics; however, such outdated approaches still have shortcomings. Multi-functional convertible nanocarriers have recently been developed as an innovative nanomedicine generation with excellent tumor infiltration abilities, such as tumor-penetrating peptide-mediated transcellular transport. The developments and limitations of nanomedicines, as well as expectations for better outcomes of tumor penetration, are discussed in this review.

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“…Drug delivery systems, which are based on nanoparticles, can facilitate targeted delivery of the drug at the place of infection, enhance drug retention time in blood, and decrease nonspecific distribution [ 49 , 50 ]. Nanoparticle surface chemistry plays an integral part in nanoparticle solubility in blood and enhances the body’s immune system.…”

Section: Role Of Nanomaterials As a Drug Carriermentioning

confidence: 99%

Nanomaterials Aiming to Tackle Antibiotic-Resistant Bacteria

Munir

Ahmad

2022

Pharmaceutics

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The global health of humans is seriously affected by the dramatic increases in the resistance patterns of antimicrobials against virulent bacteria. From the statements released by the Centers for Disease Control and Prevention about the world entering a post-antibiotic era, and forecasts about human mortality due to bacterial infection being increased compared to cancer, the current body of literature indicates that emerging tools such as nanoparticles can be used against lethal infections caused by bacteria. Furthermore, a different concept of nanomaterial-based methods can cope with the hindrance faced by common antimicrobials, such as resistance to antibiotics. The current review focuses on different approaches to inhibiting bacterial infection using nanoparticles and aiding in the fabrication of antimicrobial nanotherapeutics by emphasizing the functionality of nanomaterial surface design and fabrication for antimicrobial cargo.

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Nano-hydroxyapatite as a delivery system: overview and advancements

Cited by 70 publications

References 88 publications

Biomimetic Citrate-Coated Luminescent Apatite Nanoplatforms for Diclofenac Delivery in Inflammatory Environments

Biomimetic Citrate-Coated Luminescent Apatite Nanoplatforms for Diclofenac Delivery in Inflammatory Environments

Nanomedicine Penetration to Tumor: Challenges, and Advanced Strategies to Tackle This Issue

Nanomaterials Aiming to Tackle Antibiotic-Resistant Bacteria

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