Nano-indentation on amorphous calcium phosphate splats: Effect of droplet size on mechanical properties

Saber‐Samandari, Saeed; Gross, Kārlis Agris

doi:10.1016/j.jmbbm.2012.07.014

Cited by 14 publications

References 43 publications

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A Novel Hollow‐Tube‐Biphasic‐Whisker‐Modified Calcium Phosphate Ceramics with Simultaneously Enhanced Mechanical Strength and Osteogenic Activity

Feng

et al. 2022

Adv Funct Materials

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Due to the inherent brittleness and low mechanical strength, it is still a challenge for calcium phosphate (Ca-P) ceramics to be used in load-bearing bone defect repair. To achieve a good balance between mechanical strength and osteogenic activity, hollow-tube-whisker-modified biphasic calcium phosphate (BCP) ceramics (BCP-HW) are successfully fabricated by an in situ growth process in the present study. Compared to the initial BCP ceramics (BCP-C) and those with solid whiskers, BCP-HW exhibits larger specific surface area (3.9 times vs BCP-C) and higher mechanical strength (3.4 times vs BCP-C), endowing it with stronger stimulation on adhesion, proliferation, and osteogenic differentiation of bone marrow mesenchymal stem cells. In an intramuscular implantation model of canine, BCP-HW shows excellent osteoinductivity and promotes the maturation of new bone, and the resultant compressive strength of the implant increases to ≈12 MPa at 3 months postoperatively. In another critical-sized segmental bone defect model of rabbit femur, BCP-HW has the best repairing effect. After implantation for 6 months, much more new bone ingrowth and higher bending load are observed in BCP-HW than BCP-C. Collectively, these findings suggest that the in situ hollow-tube whisker construction possesses immense potential in expanding the applications of Ca-P ceramics to load-bearing bone defect repair.

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A Novel Hollow‐Tube‐Biphasic‐Whisker‐Modified Calcium Phosphate Ceramics with Simultaneously Enhanced Mechanical Strength and Osteogenic Activity

Feng

et al. 2022

Adv Funct Materials

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Optimization and fabrication of alginate scaffold for alveolar bone regeneration with sufficient drug release

et al. 2021

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An Improved Method of Projected Area Determination in Nanoindentation Using Image Processing With Sub-Pixel Edge Location

Ratnam

2016

Exp Tech

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Nano-indentation on amorphous calcium phosphate splats: Effect of droplet size on mechanical properties

Cited by 14 publications

References 43 publications

A Novel Hollow‐Tube‐Biphasic‐Whisker‐Modified Calcium Phosphate Ceramics with Simultaneously Enhanced Mechanical Strength and Osteogenic Activity

A Novel Hollow‐Tube‐Biphasic‐Whisker‐Modified Calcium Phosphate Ceramics with Simultaneously Enhanced Mechanical Strength and Osteogenic Activity

Optimization and fabrication of alginate scaffold for alveolar bone regeneration with sufficient drug release

An Improved Method of Projected Area Determination in Nanoindentation Using Image Processing With Sub-Pixel Edge Location

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