Nano metal-photosensitizer based on Aza-BODIPY-Cu complex for CDT-enhanced dual phototherapy

Jin, Wenjuan; Chen, Zelong; Wang, Yi; Li, Jiaxuan; Li, Jiahui; Pei, Yuxin; Pei, Zhichao

doi:10.1016/j.cclet.2023.109328

Chinese Chemical Letters

2024

DOI: 10.1016/j.cclet.2023.109328

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Nano metal-photosensitizer based on Aza-BODIPY-Cu complex for CDT-enhanced dual phototherapy

Wenjuan Jin,

Zelong Chen,

Yi Wang

et al.

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Cited by 10 publications

References 28 publications

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Self‐Assembled BODIPY@Au Core‐Shell Structures for Durable Neuroprotective Phototherapy

Wu,

Wei,

Fan

et al. 2024

ChemBioChem

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BODIPY analogs are promising photosensitizers for molecular phototherapy; however, they exhibit high dark cytotoxicity and limited singlet oxygen generation capacity. In this study, we developed self‐assembled core‐shell nanophotosensitizers by linking a bipyridine group to BODIPY (Bpy‐BODIPY) and promoting J‐aggregation on gold nanourchins. This design enhances photostability and reduces the energy gap between the lowest singlet excited state and the lower triplet state, facilitating efficient singlet oxygen production. Notably, Bpy‐BODIPY@Au significantly suppresses tau protein aggregation and enhances neuroprotective action, even in the presence of a phosphatase inhibitor. This work broadens the application of BODIPY chemistry to nanoagents for neuroprotective therapy.

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Self‐Assembled BODIPY@Au Core‐Shell Structures for Durable Neuroprotective Phototherapy

Wu,

Wei,

Fan

et al. 2024

ChemBioChem

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Oxidative stress-augmented Cu-doped hollow mesoporous carbon nanozyme for photothermal/photodynamic synergistic therapy

Yang,

Xu,

et al. 2025

Journal of Colloid and Interface Science

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IL-11-Engineered Macrophage Membrane-Coated Reactive Oxygen Species-Responsive Nanoparticles for Targeted Delivery of Doxorubicin to Osteosarcoma

Jiang,

Luo,

et al. 2024

ACS Appl. Mater. Interfaces

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Osteosarcoma (OS) is a lethal malignant orthotopic bone tumor that primarily affects children and adolescents. Biomimetic nanocarriers have attracted wide attention as a new strategy for delivering chemotherapy agents to the OS. However, challenges such as rapid clearance and limited targeting hinder the effectiveness of OS chemotherapy. In this study, we designed reactive oxygen species (ROS)responsive nanoparticles (NPs) coated with an interleukin (IL)11engineered macrophage membrane (MM). The camouflage by MMs prevents clearance of IL-11-engineered MM-coated NPs loaded with doxorubicin (IL-11/MM@NPs/Dox) by the immune system. Moreover, the macrophage membrane combined with surface-expressed IL-11 not only directed IL-11/MM@NPs/Dox to OS tissues but also selectively identified IL-11 receptor alpha (IL-11Rα)-enriched OS cells. Within these cells, elevated levels of ROS triggered the controlled release of Dox from the ROS-responsive NPs. The synergistic modification of targeted ligand conjugation and cell membrane coating on the ROS-responsive NPs enhanced drug availability and reduced toxic side effects, thereby boosting the efficacy of OS chemotherapy. In summary, our findings suggest that IL-11/MM@NPs/Dox represents a promising approach to improving OS chemotherapy efficacy while ensuring excellent biocompatibility.

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Nano metal-photosensitizer based on Aza-BODIPY-Cu complex for CDT-enhanced dual phototherapy

Cited by 10 publications

References 28 publications

Self‐Assembled BODIPY@Au Core‐Shell Structures for Durable Neuroprotective Phototherapy

Self‐Assembled BODIPY@Au Core‐Shell Structures for Durable Neuroprotective Phototherapy

Oxidative stress-augmented Cu-doped hollow mesoporous carbon nanozyme for photothermal/photodynamic synergistic therapy

IL-11-Engineered Macrophage Membrane-Coated Reactive Oxygen Species-Responsive Nanoparticles for Targeted Delivery of Doxorubicin to Osteosarcoma

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