Nano/micro-formulations of keratin in biocomposites, wound healing and drug delivery systems; recent advances in biomedical applications

Sharma, Swati; Rostamabadi, Hadis; Gupta, Shreya; Nadda, Ashok Kumar; Kharazmi, Mohammad Saeed; Jafari, Seid Mahdi

doi:10.1016/j.eurpolymj.2022.111614

Cited by 23 publications

(11 citation statements)

References 179 publications

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“…However, ensuring a high grafting rate and uniformity of grafting products is still the key to grafting modification. Blending modification involves the selection of certain functional polymers, such as thermoplastic polyurethane, polyvinyl alcohol, and polyethylene oxide, to mix with keratin in order to form macroscopic homogeneous films [ 95 , 96 , 97 ]. Blending modification not only can maintain the inherent characteristics of keratin film but can also make up for the defects of keratin film through the synergistic effect between keratin and the functional polymer(s).…”

Section: Preparation Methods Of Keratin-based Biofilmsmentioning

confidence: 99%

Preparation Methods and Functional Characteristics of Regenerated Keratin-Based Biofilms

Wang

Tong

2022

Polymers

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The recycling, development, and application of keratin-containing waste (e.g., hair, wool, feather, and so on) provide an important means to address related environmental pollution and energy shortage issues. The extraction of keratin and the development of keratin-based functional materials are key to solving keratin-containing waste pollution. Keratin-based biofilms are gaining substantial interest due to their excellent characteristics, such as good biocompatibility, high biodegradability, appropriate adsorption, and rich renewable sources, among others. At present, keratin-based biofilms are a good option for various applications, and the development of keratin-based biofilms from keratin-containing waste is considered crucial for sustainable development. In this paper, in order to achieve clean production while maintaining the functional characteristics of natural keratin as much as possible, four important keratin extraction methods—thermal hydrolysis, ultrasonic technology, eco-friendly solvent system, and microbial decomposition—are described, and the characteristics of these four extraction methods are analysed. Next, methods for the preparation of keratin-based biofilms are introduced, including solvent casting, electrospinning, template self-assembly, freeze-drying, and soft lithography methods. Then, the functional properties and application prospects of keratin-based biofilms are discussed. Finally, future research directions related to keratin-based biofilms are proposed. Overall, it can be concluded that the high-value conversion of keratin-containing waste into regenerated keratin-based biofilms has great importance for sustainable development and is highly suggested due to their great potential for use in biomedical materials, optoelectronic devices, and metal ion detection applications. It is hoped that this paper can provide some basic information for the development and application of keratin-based biofilms.

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Section: Preparation Methods Of Keratin-based Biofilmsmentioning

confidence: 99%

Preparation Methods and Functional Characteristics of Regenerated Keratin-Based Biofilms

Wang

Tong

2022

Polymers

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“…Due to their intrinsic biological properties and excellent biocompatibility, keratin-based biomaterials have shown increased interest recently and are widely used for biomedical applications such as tissue engineering, drug delivery, wound healing [51]. The main sources of keratin extractives are wool, horns, hair, nails and feathers.…”

Section: Keratinmentioning

confidence: 99%

“…The main methods used to extract and solubilize keratin are reduction, oxidation, alkaline extraction, microwave irradiation, steam explosion and by means of ionic liquids [52]. Keratin-based formulations are used as (i) hydrogels for diabetic wound dressing material, regeneration of pupal tissue, in substrates for cellular attachment and proliferation; as (ii) films for reconstruction of ocular surface, drug delivery and as (iii) fibres for tissue engineering [51].…”

Section: Keratinmentioning

confidence: 99%

Advanced Biomedical Applications of Multifunctional Natural and Synthetic Biomaterials

Chelu,

Musuc

2023

Processes

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Biomaterials are mostly any natural and synthetic materials which are compatible from a biological point of view with the human body. Biomaterials are widely used to sustain, increase, reestablish or substitute the biological function of any injured tissue and organ from the human body. Additionally, biomaterials are uninterruptedly in contact with the human body, i.e., tissue, blood and biological fluids. For this reason, an essential feature of biomaterials is their biocompatibility. Consequently, this review summarizes the classification of different types of biomaterials based on their origin, as natural and synthetic ones. Moreover, the advanced applications in pharmaceutical and medical domains are highlighted based on the specific mechanical and physical properties of biomaterials, concerning their use. The high-priority challenges in the field of biomaterials are also discussed, especially those regarding the transfer and implementation of valuable scientific results in medical practice.

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“…Keratin has been developed into films, hydrogels, dressings, and scaffolds intended for use in a variety of biomedical applications, which include nerve regeneration, wound repair, tissue regeneration, and cell culture [70,71]. Keratin confers both structural and bioactivity as well as good adhesive properties [72]. Ye et al, fabricated a keratin-based nanofibrous membrane loaded with silver nanoparticles [73].…”

Section: Keratinmentioning

confidence: 99%

Biopolymer-Based Wound Dressings with Biochemical Cues for Cell-Instructive Wound Repair

et al. 2022

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Regenerative medicine is an active research sphere that focuses on the repair, regeneration, and replacement of damaged tissues and organs. A plethora of innovative wound dressings and skin substitutes have been developed to treat cutaneous wounds and are aimed at reducing the length or need for a hospital stay. The inception of biomaterials with the ability to interact with cells and direct them toward desired lineages has brought about innovative designs in wound healing and tissue engineering. This cellular engagement is achieved by cell cues that can be biochemical or biophysical in nature. In effect, these cues seep into innate repair pathways, cause downstream cell behaviours and, ultimately, lead to advantageous healing. This review will focus on biomolecules with encoded biomimetic, instructive prompts that elicit desired cellular domino effects to achieve advanced wound repair. The wound healing dressings covered in this review are based on functionalized biopolymeric materials. While both biophysical and biochemical cues are vital for advanced wound healing applications, focus will be placed on biochemical cues and in vivo or clinical trial applications. The biochemical cues aforementioned will include peptide therapy, collagen matrices, cell-based therapy, decellularized matrices, platelet-rich plasma, and biometals.

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Nano/micro-formulations of keratin in biocomposites, wound healing and drug delivery systems; recent advances in biomedical applications

Cited by 23 publications

References 179 publications

Preparation Methods and Functional Characteristics of Regenerated Keratin-Based Biofilms

Preparation Methods and Functional Characteristics of Regenerated Keratin-Based Biofilms

Advanced Biomedical Applications of Multifunctional Natural and Synthetic Biomaterials

Biopolymer-Based Wound Dressings with Biochemical Cues for Cell-Instructive Wound Repair

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