Nano-molecularly imprinted polymers (nanoMIPs) as a novel approach to targeted drug delivery in nanomedicine

Abstract

The review highlights the recent advances in fabrication of molecularly imprinted polymers and their applicability for drug delivery.

Customizable molecular recognition: advancements in design, synthesis, and application of molecularly imprinted polymers

“…33,34 MIPs have been extensively researched for use as drug delivery systems for this exact reason, and many notable reviews are available within current literature. [35][36][37] Due to the breadth of applications for MIPs, functional monomer(s) and crosslinker(s) for use in MIP preparation are chosen with properties (charge, size, chemical identity) of the template in mind. Commonly used functional monomers and crosslinkers utilized in MIP synthesis can be found in Fig.…”

Biodegradable Magnetic Molecularly Imprinted Anticancer Drug Carrier for the Targeted Delivery of Docetaxel

“…It has been observed that biologically degradable cross-linking polymers are among the most promising materials in targeted and regulated drug delivery . Few papers are encountered in the literature regarding biodegradable molecularly imprinted polymers possessing magnetic characteristics and their applications in targeted drug delivery. − …”

Molecular imprinting as a tool for determining molecular markers: a lung cancer case

“…13 This technique is based on a phenomenon of molecular imprinting 14,15 that has already earned its place in the biomedical research as an effective tool for diagnostics and imaging. [16][17][18] The method involves a formation of nano-molecularly imprinted polymers (nanoMIPs) on the surface of cells by selfassembly of monomers possessing complementary functional groups around the side chains of exposed peptides or "epitopes" followed by polymerisation. The surface peptides capable forming the complexes with nanoparticles are protected against digestion therefore can be eluted from the nanoparticles and then sequenced using standard LC-MS/MS protocols (Fig.…”

“…13 This technique is based on a phenomenon of molecular imprinting 14,15 that has already earned its place in the biomedical research as an effective tool for diagnostics and imaging. 16–18…”