Nano neodymium oxide induces massive vacuolization and autophagic cell death in non-small cell lung cancer NCI-H460 cells

Chen, Yong; Yang, Lisong; Feng, Chao; Wen, Longping

doi:10.1016/j.bbrc.2005.09.018

Cited by 151 publications

(81 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…reported that ZNP exposure in HepG2 cells increases apoptotic cell death [36]. Recently, some NPs types have been identified as a novel class of autophagy activators and inducers of autophagic cell death [37,38]. Also, Yu et al (2009) showed that rare element NPs including samar-ium/europium and gadolinium/terbium, induce serious autophagy in human liver cells [39].…”

Section: Discussionmentioning

confidence: 99%

The effect of zinc oxide nanoparticles on mouse spermatogenesis

Talebi

Khorsandi

Moridian³

2013

J Assist Reprod Genet

127

View full text Add to dashboard Cite

Objective To evaluate the effects of zinc oxide nanoparticles on mouse spermatogenesis. Methods Thirty two adult male NMRI mice were used. Experimental Groups (ZNP-1-ZNP-3) received one of the following treatments daily for 35 days: 5, 50 and 300 mg/kg zinc oxide nanoparticles respectively. Control group received only distilled water. Epididymal sperm parameters, testicular histopathology, morphometric analysis and spermatogenesis assessments were performed for evaluation of the zinc oxide nanoparticles effects on testis. Results Epididymal sperm parameters including sperm number, motility and percentage of abnormality were significantly changed in 50 and 300 mg/kg zinc oxide nanoparticles treated mice (p<0.01). Histopathological criteria such as epithelial vacuolization, sloughing of germ and detachment were significantly increased in 50 and 300 mg/kg zinc oxide nanoparticles treated mice (p<0.001). 300 mg/kg zinc oxide nanoparticles induced formation of multinucleated giant cells in the germinal epithelium. 50 and 300 mg/kg zinc oxide nanoparticles also caused a significant decrease in seminiferous tubule diameter, seminiferous epithelium height and maturation arrest (p<0.001). Conclusion Zinc oxide nanoparticles act as testicular toxicant and further studies are needed to establish its mechanism of action upon spermatogenesis.

show abstract

Section: Discussionmentioning

confidence: 99%

The effect of zinc oxide nanoparticles on mouse spermatogenesis

Talebi

Khorsandi

Moridian³

2013

J Assist Reprod Genet

127

View full text Add to dashboard Cite

show abstract

“…Blockage of this autophagy response prevents cell death. 50 In this way, the autophagic process of cancer cells may be either an indicator of death or survival tendency.…”

Section: Autophagy and Cancer Cellsmentioning

confidence: 99%

Radiation-induced autophagy in normal and cancer cells: Towards novel cytoprotection and radio-sensitization policies?

Zois¹,

Koukourakis²

2009

Autophagy

124

101

View full text Add to dashboard Cite

Autophagy or Type II programmed cell death (PCD) is a major intracellular pathway for the degradation and recycling of proteins, ribosomes and entire organelles. The role of this pathway in the antitumor effect of radiotherapy and in radiation toxicity is obscure. A complicated machinery of genes and proteins is involved in the regulation of autophagy as a response to a variety of stress factors including hypoxia, nutrient deprivation, cytotoxic agents and radiotherapy. Continuously accumulating data suggest that autophagic response of cancer cells to radiotherapy is a major pathway which, in contrast to apoptosis that leads to death, may lead to either death or cellular survival. A variety of agents have been recognized that induce or block autophagy, directly interfering with the cytotoxic effect of radiotherapy. Simultaneous targeting of autophagy and apoptosis during radiotherapy seems to further augment the antitumor effect. Radiobiology research should focus on the differential effect of fractionation on the induction of autophagy in different tumors and on the manipulation of this with autophagy triggering agents. Whether manipulation of this pathway in normal tissues may be used to confer cytoprotection also deserves thorough investigation. Moreover, the role of pretreatment autophagic indices in tumor cells in predicting radiotherapy and chemotherapy outcome should be examined in translational studies.

show abstract

“…3 There are many examples in the literature of nanoscale particulates, such as quantum dots, inducing elevated levels of autophagic vacuoles in both animal and human cell culture models. [4][5][6][7][8] Such nanomaterials include: nanoscale carbon black, fullerene and fullerene derivatives, nanoscale neodymium oxide, and protein-coated quantum dots. The induction of autophagic vacuoles in these instances was characterized at the ultrastructural cellular level via electron microscopy detection of vacuoles in treated cells, through immunoblot detection of LC3-I to LC3-II conversion (an established marker of autophagy activity) in cell lysates, and/or cellular immunolabeling of punctate LC3-II autophagosome incorporation.…”

Section: Introductionmentioning

confidence: 99%

Role for nanomaterial-autophagy interaction in neurodegenerative disease

Stern

Johnson²

2008

Autophagy

View full text Add to dashboard Cite

Nanotechnology is the control and manipulation of materials in the size range of 1-100 nm. Due to increasing research into the potential beneficial applications of nanotechnology, there is an urgent need for the study of possible health risks. Several researchers, including those in our laboratory, have demonstrated elevated levels of autophagic vacuoles upon exposure of cells to certain nanomaterials, including carbon-and metal-based nanoparticles. While this apparent increase in autophagic activity may be an appropriate cellular response toward nanomaterial clearance, often the interaction between nanomaterials and the autophagy pathway is disruptive, resulting in severe morphological changes and coincident cell death. Interestingly, epidemiological studies have identified an association between exposure to combustion-derived ambient particles (which are predominantly nanoscale) and neurological conditions with Alzheimer's and Parkinson's disease-like pathologies. Becuse impaired autophagy may play an important role in the pathogenesis of these and other diseases, it is intriguing to speculate about the plausible involvement of nanoscale particulates in this process. The interaction of nanomaterials with the autophagy pathway, and the potential negative consequences of resulting autophagy dysfunction, should be explored further.

show abstract

Nano neodymium oxide induces massive vacuolization and autophagic cell death in non-small cell lung cancer NCI-H460 cells

Cited by 151 publications

References 23 publications

The effect of zinc oxide nanoparticles on mouse spermatogenesis

The effect of zinc oxide nanoparticles on mouse spermatogenesis

Radiation-induced autophagy in normal and cancer cells: Towards novel cytoprotection and radio-sensitization policies?

Role for nanomaterial-autophagy interaction in neurodegenerative disease

Contact Info

Product

Resources

About