Nano shield: a new tetrahedral framework nucleic acids-based solution to radiation-induced mucositis

Zhang, Geru; Huang, Liwei; Feng, Maogeng; Gao, Yang; Yao, Yangxue; Li, Songhang; Li, Xiaobing; Lin, Yunfeng

doi:10.1039/d2nr07174f

Nanoscale

2023

DOI: 10.1039/d2nr07174f

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Nano shield: a new tetrahedral framework nucleic acids-based solution to radiation-induced mucositis

Geru Zhang

Liwei Huang

Maogeng Feng

et al.

Abstract: Radiation-induced oral mucositis (RIOM) is considered to be one of the most important public health problems today, affecting the overall well-beings of millions of patients who has received radiotherapy. Nevertheless,...

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2024

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Unveiling the Potential of Tetrahedral DNA Frameworks in Clinical Medicine: Mechanisms, Advances, and Future Perspectives

Yang,

Shi,

Wang

et al. 2024

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As deoxyribonucleic acis (DNA) nanotechnology advances, DNA, a fundamental biological macromolecule, has been employed to treat various clinical diseases. Among the advancements in this field, tetrahedral frameworks nucleic acids (tFNAs) have gained significant attention due to their straightforward design, structural simplicity, low cost, and high yield since their introduction by Turberfield in the early 2000s. Due to its stable spatial structure, tFNAs can resist the impact of innate immune responses on DNA and nuclease activity. Meanwhile, structural programmability of tFNAs allows for the development of static tFNA‐based nanomaterials through the engineering of functional oligonucleotides or therapeutic molecules and dynamic tFNAs through the attachment of stimuli‐responsive DNA apparatuses. This review first summarizes the key merits of tFNAs, including natural biocompatibility, biodegradability, structural stability, unparalleled programmability, functional diversity, and efficient cellular internalization. Based on these strengths, this review comprehensively analyzes applications of tFNAs in different clinical settings, including orthopedics, stomatology, urinary system diseases, liver‐related diseases, tumors, infection, neural system diseases, ophthalmic diseases, and immunoprophylaxis. We also discuss the limitations of tFNAs and the challenges encountered in preclinical studies. This review provides new perspectives for future research and valuable guidance for researchers working in this field.

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Unveiling the Potential of Tetrahedral DNA Frameworks in Clinical Medicine: Mechanisms, Advances, and Future Perspectives

Yang,

Shi,

Wang

et al. 2024

Small

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Suppression of pathological neovascularization by anti-Flt1 peptide functionalized DNA tetrahedron

Tang,

Yang,

et al. 2024

Chemical Engineering Journal

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Biomaterials-mediated radiation-induced diseases treatment and radiation protection

Man,

Shen,

Song

et al. 2024

Journal of Controlled Release

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Nano shield: a new tetrahedral framework nucleic acids-based solution to radiation-induced mucositis

Abstract: Radiation-induced oral mucositis (RIOM) is considered to be one of the most important public health problems today, affecting the overall well-beings of millions of patients who has received radiotherapy. Nevertheless,...

Cited by 3 publications

References 53 publications

Unveiling the Potential of Tetrahedral DNA Frameworks in Clinical Medicine: Mechanisms, Advances, and Future Perspectives

Unveiling the Potential of Tetrahedral DNA Frameworks in Clinical Medicine: Mechanisms, Advances, and Future Perspectives

Suppression of pathological neovascularization by anti-Flt1 peptide functionalized DNA tetrahedron

Biomaterials-mediated radiation-induced diseases treatment and radiation protection

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