Nano SIM@ZIF-8 modified injectable High-intensity biohydrogel with bidirectional regulation of osteogenesis and Anti-adipogenesis for bone repair

Surface modification of the Ti surface with nanoscale bio-MOF-1 for improving biocompatibility and osteointegration in vitro and in vivo

“…For long-term mineralization in BMSCs, osteocalcin protein (OCN), a matrix protein that is mainly localized in bone tissues, is significant for calcium deposits in the late stage. 89,90 BMP4, which is structurally similar to BMP2, is a member of the transforming growth factor-β (TGF-β) and is crucial for bone formation. 91 Similar to the result of immunochemistry staining, the expressions of OCN, COL1, and BMP4 in the bio-MOF-1@AHT-1/32 group appeared to be higher in comparison to the AHT group.…”

Metal–organic gels: recent advances in their classification, characterization, and application in the pharmaceutical field

“…213 Therefore, bidirectional regulation schemes that inhibit lipid production while encouraging osteogenesis to emerge are unique strategies for bone regeneration in a hyperlipidemic microenvironment. Based on the foregoing concepts, Qiao et al 140 designed an injectable nanotherapeutic platform for bone regeneration, which could bi-directionally regulate osteogenesis promotion and fat formation inhibition. The SIM@ZIF-8/PEGDA/SA bio-hydrogel was a combination of simvastatin-loaded ZIF-8 (nano SIM@ZIF-8), poly(ethylene glycol) diacrylate (PEGDA), and sodium alginate (SA).…”

Metal-based nano-delivery platform for treating bone disease and regeneration

“…ZIF-8 is a space-filling packing with the topology of truncated octahedrons and a pore size of 11.6 Ǻ ( He et al, 2021 ). It has been reported that ZIF-8 can effectively deliver one or more small-molecule drugs such as alendronate (Ald), DOX ( Xue X. H. et al, 2021 ), curcumin ( Wang Y. T. et al, 2020 ), risedronate ( Cheng et al, 2020 ), dexamethasone ( Ran et al, 2018 ), 5-fluorouracil, and indocyanine green (ICG) ( Ting et al, 2022 ), and simvastatin ( Qiao M. et al, 2022 ). ZIF-8 has also been demonstrated to be an effective non-viral vector for delivering small noncoding RNAs such as microRNAs (miRNAs) in addition to viral vectors ( Feng et al, 2022 ).…”

“…For example, MNPs comprising ZIF-8 with Zn as the coordination core have assisted numerous novel bone tissue engineering materials in the completion of complex bone repair tasks ( Figure 4 ). In the face of bone metabolism disorders and hyperlipidemia, Qiao et al ( Qiao M. et al, 2022 ) used ZIF-8 to encapsulate the small-molecule drug, simvastatin, to reduce serum cholesterol levels to form SIM@ZIF-8 nanocarrier particles, and SIM@ZIF-8 for enhancing the performance of poly (ethylene glycol) diacrylate (PEGDA) and sodium alginate (SA) to form SIM@ZIF-8/PEGDA/SA (nSZPS) composite biogels. The corresponding in vivo and in vitro experiments confirmed that using SIM@ZIF-8, nSZPS can inhibit adipogenic differentiation and promote osteogenic differentiation of BMSCs in vitro , as well as promote blood lipid lowering and osseointegration of bone in hyperlipidemia rats ( Figure 3 ).…”