Nano-sized carriers in gene therapy for renal fibrosis<i>in vivo</i>

Miyazawa, Haruhisa; Hirai, Keiji; Ookawara, Susumu; Ishibashi, Keiichiro; Morishita, Yoshiyuki

doi:10.1080/20022727.2017.1331099

Cited by 9 publications

(5 citation statements)

References 75 publications

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“…More than 2597 clinical trials on gene therapy have been conducted in 38 countries, and this approach has been shown to be effective in treating various diseases 72 . Gene therapies that treat disorders caused by single‐gene mutations are among the most advanced gene therapies on the market.…”

Section: Gene Therapy: Concept and Historymentioning

confidence: 99%

“…Until today, some well‐known single‐gene diseases, such as cystic fibrosis and muscular dystrophy, have made little progress due to the limitation of alternative gene strategies, and researchers are trying to overcome these limitations 73 . Other conditions such as cardiac arrhythmias, 74 osteoarthritis, 75 hearing and balance disorder, 76 renal disease, 72 primary immunodeficiency, nervous system disorders, 77 β‐thalassemia, 78 haemophilia, 79,80 diabetes 81 and different types of cancer 82 are also the targets of gene therapy.…”

Section: Gene Therapy: Concept and Historymentioning

confidence: 99%

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Gene therapy: A promising approach for breast cancer treatment

Dastjerd

Valibeik

Monfared

et al. 2021

Cell Biochemistry & Function

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Breast cancer (BC) is the most prevalent malignancy and the second leading cause of death among women worldwide that is caused by numerous genetic and environmental factors. Hence, effective treatment for this type of cancer requires new therapeutic approaches. The traditional methods for treating this cancer have side effects, therefore so much research have been performed in last decade to find new methods to alleviate these problems. The study of the molecular basis of breast cancer has led to the introduction of gene therapy as an effective therapeutic approach for this cancer. Gene therapy involves sending genetic material through a vector into target cells, which is followed by a correction, addition, or suppression of the gene. In this technique, it is necessary to target tumour cells without affecting normal cells. In addition, clinical trial studies have shown that this approach is less toxic than traditional therapies. This study will review various aspects of breast cancer, gene therapy strategies, limitations, challenges and recent studies in this area.

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Section: Gene Therapy: Concept and Historymentioning

confidence: 99%

Section: Gene Therapy: Concept and Historymentioning

confidence: 99%

Gene therapy: A promising approach for breast cancer treatment

Dastjerd

Valibeik

Monfared

et al. 2021

Cell Biochemistry & Function

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“…3). 29 Among many nanomaterials, metal organic frameworks (MOFs) have attracted wide attention due to their porosity, large specific surface area, stable results and modifiability. MOFs are a class of porous materials formed by metal ions or metal clusters connected with organic ligands through strong coordination bonds.…”

Section: Drug Delivery In Renal Fibrosismentioning

confidence: 99%

Advances in drug delivery-based therapeutic strategies for renal fibrosis treatment

Huang,

Lu,

Chen

et al. 2024

J. Mater. Chem. B

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“…Currently, the treatment of renal fibrosis mainly focuses on controlling disease progression, delaying renal function impairment, and relieving symptoms. , In recent years, many treatment methods have been researched and explored. For example, technologies such as stem cell therapy, gene therapy, proteomics, and metabolomics provide encouraging ideas and approaches for treating renal fibrosis . However, renal fibrosis remains challenging to cure clinically, and there is a continuous need to develop more effective strategies to combat it.…”

Section: Introductionmentioning

confidence: 99%

Precisely Regulating M2 Subtype Macrophages for Renal Fibrosis Resolution

Luo,

Wang,

et al. 2023

ACS Nano

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Macrophages are central to the pathogenesis of kidney disease and serve as an effective therapeutic target for kidney injury and fibrosis. Among them, M2-type macrophages have double-edged effects regarding anti-inflammatory effects and tissue repair. Depending on the polarization of the M2 subtypes (M2a or M2c) in the diseased microenvironment, they can either mediate normal tissue repair or drive tissue fibrosis. In renal fibrosis, M2a promotes disease progression through macrophage-to-myofibroblast transition (MMT) cells, while M2c possesses potent anti-inflammatory functions and promotes tissue repair, and is inhibited. The mechanisms underlying this differentiation are complex and are currently not well understood. Therefore, in this study, we first confirmed that M2a-derived MMT cells are responsible for the development of renal fibrosis and demonstrated that the intensity of TGF-β signaling is a major factor determining the differential polarization of M2a and M2c. Under excessive TGFβ stimulation, M2a undergoes a process known as MMT cells, whereas moderate TGF-β stimulation favors the polarization of M2c phenotype macrophages. Based on these findings, we employed targeted nanotechnology to codeliver endoplasmic reticulum stress (ERS) inhibitor (Ceapin 7, Cea or C) and conventional glucocorticoids (Dexamethasone, Dex or D), precisely modulating the ATF6/TGF-β/Smad3 signaling axis within macrophages. This approach calibrated the level of TGF-β stimulation on macrophages, promoting their polarization toward the M2c phenotype and suppressing excessive MMT polarization. The study indicates that the combination of ERS inhibitor and a first-line anti-inflammatory drug holds promise as an effective therapeutic approach for renal fibrosis resolution.

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Nano-sized carriers in gene therapy for renal fibrosisin vivo

Cited by 9 publications

References 75 publications

Gene therapy: A promising approach for breast cancer treatment

Gene therapy: A promising approach for breast cancer treatment

Advances in drug delivery-based therapeutic strategies for renal fibrosis treatment

Precisely Regulating M2 Subtype Macrophages for Renal Fibrosis Resolution

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