Nano-sized cationic polymeric magnetic liposomes significantly improves drug delivery to the brain in rats

Abstract

In recent years, cationic polymeric magnetic liposomes have shown greater stability and prolonged circulation half-life over traditional liposomes. Here, we examined the capability of cationic polymeric magnetic liposomes in delivering drugs into the brain under magnetic targeting with paclitaxel as the loaded agent. We found that the fabricated paclitaxel-loaded magnetic liposomes had a uniform diameter of 20 nm and were superparamagnetic. After they were injected into rats by the caudal vein, brain paclitaxel concentration increased 2-5 folds without magnetic targeting and 5-15 folds after magnetic targeting. The high brain concentration was maintained for more than 8 h, which was significantly longer than that for pure paclitaxel injection. When the liposomes were given via the internal carotid artery at 10% of the dose given via the caudal vein, paclitaxel in the brain was increased by 1.5 folds, indicating that intra-arterial administration enhanced delivery efficiency remarkably. Prussian blue staining of the cortex showed that the magnetic liposomes were aggregated in the cortex vasculature and the cortex cells were under magnetic targeting, indicating that the drugs were delivered across the nearly impermeable blood-brain barrier. These results showed that the nano-sized cationic polymeric magnetic liposomes are potential tools for magnetic drug delivery to the brain.

Cationic surface charge enhances early regional deposition of liposomes after intracarotid injection

“…However, few studies have investigated brain tissue uptake of liposomes after a short exposure following the intraarterial (IA) injections. Recently Zhao et al reported 15-fold greater uptake of magnetically targeted cationic liposomes after IA injection, compared to intravenous injection [3]. We also observed similar advantages of cationic liposomal preparations during IA injection particularly when injected during transient cerebral hypoperfusion (TCH).…”

Recent trends in the development of nanophytobioactive compounds and delivery systems for their possible role in reducing oxidative stress in Parkinson’s disease models

“…Several nanosynthetic compounds have been designed to effectively deliver drugs to the brain. 119,120 Similarly, phtobioactive nanoliposomes, such as Orthosiphon stamineus extract nanoliposomes, have higher bioavailability and in vitro antioxidant activity. 121 Curcumin encapsulated nanoliposomes show higher bioavailability after oral treatment in rats with enhanced antioxidant activity.…”

Targeted Drug Delivery to the Brain Using Magnetic Nanoparticles

“…Naked SPIONs are also able to passage brain endothelial cells in culture subjected to an external magnetic field [8]. Interestingly, many studies show the advantages of incorporating SPIONs into liposomes thus forming magneto-liposomes that are magnetic responsive [12,24,25,[65][66][67]. Liposomes denote a group of well-established drug carriers for drug delivery purposes.…”