Nano-sized polymer and polymer-coated particles in electrokinetic separations

Карцова, Л. А.; Makeeva, D. V.; Davankov, V. A.

doi:10.1016/j.trac.2019.115656

Cited by 13 publications

(4 citation statements)

References 73 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The combination with polymers can improve the selectivity and repeatability of CE chiral analysis, and gradually become the most promising chiral selector. Related application examples have also been mentioned in previous reviews [ 109 ].…”

Section: Chromatographic Separationmentioning

confidence: 99%

Chiral Recognition for Chromatography and Membrane-Based Separations: Recent Developments and Future Prospects

et al. 2021

View full text Add to dashboard Cite

With the rapid development of global industry and increasingly frequent product circulation, the separation and detection of chiral drugs/pesticides are becoming increasingly important. The chiral nature of substances can result in harm to the human body, and the selective endocrine-disrupting effect of drug enantiomers is caused by differential enantiospecific binding to receptors. This review is devoted to the specific recognition and resolution of chiral molecules by chromatography and membrane-based enantioseparation techniques. Chromatographic enantiomer separations with chiral stationary phase (CSP)-based columns and membrane-based enantiomer filtration are detailed. In addition, the unique properties of these chiral resolution methods have been summarized for practical applications in the chemistry, environment, biology, medicine, and food industries. We further discussed the recognition mechanism in analytical enantioseparations and analyzed recent developments and future prospects of chromatographic and membrane-based enantioseparations.

show abstract

Section: Chromatographic Separationmentioning

confidence: 99%

Chiral Recognition for Chromatography and Membrane-Based Separations: Recent Developments and Future Prospects

et al. 2021

View full text Add to dashboard Cite

show abstract

“…The increased surface area and high concentration of a chiral selector on the inner capillary surface can result in enantioselectivity enhancement and the possibility to carry out chiral separation without the need for introducing chiral selectors to the BGEs, for example, in CEC mode [7,8]. NPs actively used in CE applications can consist of a range of materials, such as carbon, silica, metals and metal oxides, and polymers [9]. Among all, gold nanoparticles (GNPs) are one of the most promising due to their unique ability to spe-cific interactions with analytes and modifiers, simplicity of modification, and straightforward synthesis with precise size control and narrow size distribution [10].…”

Section: Introductionmentioning

confidence: 99%

Multilayer coatings based on gold nanoparticles and polymers with bovine serum albumin as a functional layer for the chiral separation in capillary electrochromatography

Makeeva,

Morgacheva,

Kolobova

et al. 2024

J of Separation Science

View full text Add to dashboard Cite

In this study, we developed physically adsorbed multi‐layer coatings using poly‐l‐lysine or poly(diallyldimethylammonium chloride) and gold nanoparticles, which were functionalized with bovine serum albumin for the chiral separation in electrochromatography. The approach involves sequentially depositing positively charged polymers and negatively charged citrate‐stabilized gold nanoparticles. By repeating this modification cycle, we created two‐ and four‐layer coatings, which were sequentially functionalized with albumin forming three‐ and five‐layer coatings that were finally applied for the separation of enantiomers of dl‐tryptophan. The formed coatings exhibit stability across a pH range of 2–10 and feature a dense, uniform surface, as confirmed by scanning electron microscope images. The number of layers impacted nanoparticle deposition density, with five‐layer coatings being denser than three‐layer ones. Five‐layer coatings enable baseline separation of dl‐tryptophan enantiomers, whereas three‐layer coatings require the presence of albumin in the background electrolyte for separation. Therefore, increasing the number of layers and gold nanoparticles density enhances albumin active center concentration on capillary walls, improving the separation of dl‐tryptophan enantiomers. The five‐layer coatings can be easily fabricated and possess good repeatability of analytes migration time.

show abstract

“…To reduce EOF under neutral and alkaline conditions, dynamic and permanent capillary coatings are commonly employed [25,26]. An alternative to conventional capillary coating methods has been recently developed, exploiting the potential of nanomaterials as nano-coating layers [27]. EOF can also be suppressed by significantly increasing the electrolyte viscosity [28,29].…”

Section: ) Introductionmentioning

confidence: 99%

Electroosmotic flow modulation for improved electrokinetic preconcentration: Application to capillary electrophoresis of fluorescent magnetic nanoparticles

Nguyen

Smadja

Taverna

et al. 2021

Analytica Chimica Acta

View full text Add to dashboard Cite

It is reported in this study a new approach for modulation and even suppression of the electroosmotic flow (EOF) to achieve better electrokinetic preconcentration in capillary electrophoresis This is based on the augmentation of the buffer's concentrations to very high levels (more than a thousand of mM) without recourse to any dynamic/permanent coating nor viscous gel. The use of large weakly charged molecules as background electrolyte's constituents allows working at extreme concentration ranges without penalty of high electric currents and Joule heating. By this way, the electroosmotic mobility could be modulated over a wide range (2 -60 × 10 -5 cm 2 .V -1 .s -1 under alkaline conditions), and suppressed to levels equivalent to those obtained with several neutral coatings. For demonstration, this new approach was applied for sensitive determination of core-shell magnetic nanoparticles (CSMNPs) having high potential for healthcare applications such as imaging agents for diagnostics and controllable cargos for nanomedicine. Different profiles were achieved for purposemade and commercial magnetic nanoparticles using CE coupled with light-emitting-diode induced fluorescence (LEDIF) detection. Compared to the conventional capillary electrophoresis (CE-UV) method for characterization of magnetic nanoparticles, our proposed approach with fluorescent detection and EOF-assisted preconcentration offers almost 350-fold sensitivity improvement. Furthermore, our scheme can be used for monitoring the interaction between CSMNPs and target pharmaceutical molecules, serving for drug delivery development. A preliminary study with two antibiotics using this approach revealed that kanamycin interacts better with the target nanoparticles than amikacin.

show abstract

Nano-sized polymer and polymer-coated particles in electrokinetic separations

Cited by 13 publications

References 73 publications

Chiral Recognition for Chromatography and Membrane-Based Separations: Recent Developments and Future Prospects

Chiral Recognition for Chromatography and Membrane-Based Separations: Recent Developments and Future Prospects

Multilayer coatings based on gold nanoparticles and polymers with bovine serum albumin as a functional layer for the chiral separation in capillary electrochromatography

Electroosmotic flow modulation for improved electrokinetic preconcentration: Application to capillary electrophoresis of fluorescent magnetic nanoparticles

Contact Info

Product

Resources

About