Nano sponges: A targeted drug delivery system and its applications

Abstract

The recent innovative advance in nanotechnology has led to the development of targeted drug delivery system. Targeting a molecule to a particular site with the help of a drug delivery system efficiently requires the use of specialized drug delivery systems. The invention of Nano sponges has become a significant step in overcoming the problems associated with conventional drug delivery systems. These are able to carry both hydrophilic and hydrophobic drugs. Nano sponge technology widely provide the controlled and predictable release of the drug to the targeted site. The Nano sponge particles circulate around the body and get attached with the target site and release the drug. A wide variety of drugs can be incorporated in the Nano sponge formulation since it possess a porous structure in nature. Nano sponge technology has been studied widely for the drug delivery by oral administration, topical administration and parenteral administration. Nano sponges can be used to prevent drug and protein degradation. Another important characteristic of Nano sponge is that they can improve the solubility of poorly water soluble drug. In this review advantages, composition, method of preparation, evaluation and application of different formulations of drugs and recent studies on Nano sponge have been discussed.

The ascension of nanosponges as a drug delivery carrier: preparation, characterization, and applications

“…The change in temperature affects the drug and the NS complexation. Constancy constant of the drug and the composite formed with the NS decreases with increase in temperature, which thus decreases the contact forces for example Van der Waal forces and the water-hating forces [ 72 ].…”

A Novel Revolutionary Approach of a Synthesis and Application of Targeted Nanosponge Drug Delivery

“…In one of the article, it was encapsulation [34] of Gammaoryzanol showed a good protection from photodegradation. [35] Gamma-oryzanol. This is a ferulic acid ester mixture.…”