Nano spray dried antibacterial coatings for dental implants

Baghdan, Elias; Raschpichler, Michael; Lutfi, W. J. Wan; Pinnapireddy, Shashank Reddy; Pourasghar, Marcel; Schäfer, Jens; Schneider, Marc; Bakowsky, Udo

doi:10.1016/j.ejpb.2019.03.003

Cited by 33 publications

(24 citation statements)

References 41 publications

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“…CUR-NP showed a typical biphasic release pattern of PLGA nanoparticles with a burst release of around 20% loading within the initial 4 h, followed by controlled release of 90% drug loading over the following 7 days. Burst release is most likely attributed to the drug absorbed to the particle’s surface, while controlled release might be induced through a combination of erosion and diffusion processes [52,53]. Furthermore, drug release was much faster in acidic medium compared to pH 7.4 which could be caused by a faster degradation rate of PLGA under acidic conditions [33].…”

Section: Resultsmentioning

confidence: 99%

Photodynamic Therapy of Ovarian Carcinoma Cells with Curcumin-Loaded Biodegradable Polymeric Nanoparticles

et al. 2019

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Accumulation of photosensitisers in photodynamic therapy in healthy tissues is often the cause of unwanted side effects. Using nanoparticles, improved bioavailability and site-specific drug uptake can be achieved. In this study, curcumin, a natural product with anticancer properties, albeit with poor aqueous solubility, was encapsulated in biodegradable polymeric poly(lactic-co-glycolic acid) (PLGA) nanoparticles (CUR-NP). Dynamic light scattering, laser Doppler anemometry and atomic force microscopy were used to characterise the formulations. Using haemolysis, serum stability and activated partial thromboplastin time tests, the biocompatibility of CUR-NP was assessed. Particle uptake and accumulation were determined by confocal laser scanning microscopy. Therapeutic efficacy of the formulation was tested in SK-OV-3 human ovarian adenocarcinoma cells post low level LED irradiation by determining the generation of reactive oxygen species and cytotoxicity. Pharmacologic inhibitors of cellular uptake pathways were used to identify the particle uptake mechanism. CUR-NP exhibited better physicochemical properties such as stability in the presence of light and improved serum stability compared to free curcumin. In addition, the novel nanoformulation facilitated the use of higher amounts of curcumin and showed strong apoptotic effects on tumour cells.

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Section: Resultsmentioning

confidence: 99%

Photodynamic Therapy of Ovarian Carcinoma Cells with Curcumin-Loaded Biodegradable Polymeric Nanoparticles

et al. 2019

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“…One promising strategy for providing strong fixation and low failure of dental implants is surface coating with nanoparticles to disrupt bacterial colonization, so that osseointegration may be successfully induced in the absence of bacterial infection. [191,217,218] Bone mineral density and bone formation were enhanced by embedding silver nanoparticles on the implant surface, without causing damage to tissues surrounding the dental implants. Furthermore, no toxicity to the viability and differentiation of bone marrow mesenchymal stem cells was observed with this coating method.…”

Section: Oral Surgery and Implantologymentioning

confidence: 99%

Drug Delivery (Nano)Platforms for Oral and Dental Applications: Tissue Regeneration, Infection Control, and Cancer Management

et al. 2021

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The oral cavity and oropharynx are complex environments that are susceptible to physical, chemical, and microbiological insults. They are also common sites for pathological and cancerous changes. The effectiveness of conventional locally-administered medications against diseases affecting these oral milieus may be compromised by constant salivary flow. For systemically-administered medications, drug resistance and adverse side-effects are issues that need to be resolved. New strategies for drug delivery have been investigated over the last decade to overcome these obstacles. Synthesis of nanoparticle-containing agents that promote healing represents a quantum leap in ensuring safe, efficient drug delivery to the affected tissues. Micro/nanoencapsulants with unique structures and properties function as more favorable drug-release platforms than conventional treatment approaches. The present review provides an overview of newly-developed nanocarriers and discusses their potential applications and limitations in various fields of dentistry and oral medicine.

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“…The type of drug (hydrophilic or hydrophobic) would determine the solvent used in the emulsion (Makadia and Siegel, 2011). Recently, spray drying was used in the preparation of a PLGA nanoformulation for sustained treatment of tuberculosis (TB) (Kalombo et al, 2019) and in the fabrication of a carrier for antibiotic coating of dental implants (Baghdan et al, 2019). This method is highly advantageous because it is suitable for hydrophobic and hydrophilic drugs and can be used for sensitive compounds since the conditions are mild.…”

Section: Spray Dryingmentioning

confidence: 99%

The Design of Poly(lactide-co-glycolide) Nanocarriers for Medical Applications

Essa

Kondiah

Choonara

et al. 2020

Front. Bioeng. Biotechnol.

166

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Polymeric biomaterials have found widespread applications in nanomedicine, and poly(lactide-co-glycolide), (PLGA) in particular has been successfully implemented in numerous drug delivery formulations due to its synthetic malleability and biocompatibility. However, the need for preconception in these formulations is increasing, and this can be achieved by selection and elimination of design variables in order for these systems to be tailored for their specific applications. The starting materials and preparation methods have been shown to influence various parameters of PLGA-based nanocarriers and their implementation in drug delivery systems, while the implementation of computational simulations as a component of formulation studies can provide valuable information on their characteristics. This review provides a critical summary of the synthesis and applications of PLGA-based systems in bio-medicine and outlines experimental and computational design considerations of these systems.

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Nano spray dried antibacterial coatings for dental implants

Cited by 33 publications

References 41 publications

Photodynamic Therapy of Ovarian Carcinoma Cells with Curcumin-Loaded Biodegradable Polymeric Nanoparticles

Photodynamic Therapy of Ovarian Carcinoma Cells with Curcumin-Loaded Biodegradable Polymeric Nanoparticles

Drug Delivery (Nano)Platforms for Oral and Dental Applications: Tissue Regeneration, Infection Control, and Cancer Management

The Design of Poly(lactide-co-glycolide) Nanocarriers for Medical Applications

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