Nano-structured antimicrobial surfaces: From nature to synthetic analogues

Elbourne, Aaron; Ivanova, Elena P.

doi:10.1016/j.jcis.2017.07.021

Cited by 306 publications

(269 citation statements)

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“…1,2 This increase in research activity has been largely a response to the increasing prevalence of multi-resistant bacteria and their associated infections. [3][4][5][6][7][8] The seriousness of this epidemic has been highlighted by the Infectious Diseases Society of America (IDSA), which has labeled antibacterial resistance as a "public health crisis".…”

Section: Introductionmentioning

confidence: 99%

“…One such technology is the formation of surface nanostructures that can physically resist bacterial attachment or deactivate bacteria upon attachment to the surface. 1,14 This approach can be largely divided into two categories, namely (1) antifouling surfaces, whereby the extent of bacterial attachment is limited by an unfavourable surface nano-architecture, [15][16][17][18][19] or (2) antibacterial surfaces, where the surface induces cell lysis during bacterial attachment. 1,2,[20][21][22] In the latter case, the interaction of bacteria with high-aspect-ratio nanostructures prevents biolm formation via a physicomechanical mechanism.…”

Section: Introductionmentioning

confidence: 99%

“…1,14 This approach can be largely divided into two categories, namely (1) antifouling surfaces, whereby the extent of bacterial attachment is limited by an unfavourable surface nano-architecture, [15][16][17][18][19] or (2) antibacterial surfaces, where the surface induces cell lysis during bacterial attachment. 1,2,[20][21][22] In the latter case, the interaction of bacteria with high-aspect-ratio nanostructures prevents biolm formation via a physicomechanical mechanism. 1,[21][22][23][24][25][26][27] Upon bacterial adsorption, the cell wall experiences a self-induced mechanical stress via the action of the substratum surface, which results in cell lysis, and in-turn, cell death.…”

Section: Introductionmentioning

confidence: 99%

“…1,2,[20][21][22] In the latter case, the interaction of bacteria with high-aspect-ratio nanostructures prevents biolm formation via a physicomechanical mechanism. 1,[21][22][23][24][25][26][27] Upon bacterial adsorption, the cell wall experiences a self-induced mechanical stress via the action of the substratum surface, which results in cell lysis, and in-turn, cell death. 22,25 Importantly, since the bacteria are ruptured while attaching onto the surfaces, the bacteria are unable to establish a biolm.…”

Section: Introductionmentioning

confidence: 99%

“…22,25 More importantly, this process appears to be independent of surface chemistry, meaning that bacteria are unable to develop a protective response. 1,2,[15][16][17][22][23][24][25][26][27][28][29][30][31][32][33][34][35][36][37][38] Such surface nanostructuring provides a viable replacement for conventional antibacterial surface technologies that involve the incorporation of antibiotics or additive chemicals. A comparative analysis of biocidal nanostructures has suggested that short, sharp nanofeatures tend to exhibit greater biocidal behavior;…”

Section: Introductionmentioning

confidence: 99%

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Multi-directional electrodeposited gold nanospikes for antibacterial surface applications

et al. 2019

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The incorporation of high-aspect-ratio nanostructures across surfaces has been widely reported to impart antibacterial characteristics to a substratum. This occurs because the presence of such nanostructures can induce the mechanical rupture of attaching bacteria, causing cell death. As such, the development of highefficacy antibacterial nano-architectures fabricated on a variety of biologically relevant materials is critical to the wider acceptance of this technology. In this study, we report the antibacterial behavior of a series of substrata containing multi-directional electrodeposited gold (Au) nanospikes, as both a function of deposition time and precursor concentration. Firstly, the bactericidal efficacy of substrata containing Au nanospikes was assessed as a function of deposition time to elucidate the nanopattern that exhibited the greatest degree of biocidal activity. Here, it was established that multi-directional nanospikes with an average height of $302 nm AE 57 nm (formed after a deposition time of 540 s) exhibited the greatest level of biocidal activity, with $88% AE 8% of the bacterial cells being inactivated. The deposition time was then kept constant, while the concentration of the HAuCl 4 and Pb(CH 3 COO) 2 precursor materials (used for the formation of the Au nanospikes) was varied, resulting in differing nanospike architectures.Altering the Pb(CH 3 COO) 2 precursor concentration produced multi-directional nanostructures with a wider distribution of heights, which increased the average antibacterial efficacy against both Gramnegative Pseudomonas aeruginosa and Gram-positive Staphylococcus aureus bacteria. Importantly, the in situ electrochemical fabrication method used in this work is robust and straightforward, and is able to produce highly reproducible antibacterial surfaces. The results of this research will assist in the wider utilization of mechano-responsive nano-architectures for antimicrobial surface technologies.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Multi-directional electrodeposited gold nanospikes for antibacterial surface applications

et al. 2019

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Role of Nanotechnology in the Management of Indoor Fungi

Gámez-Espinosa

Roque

Bellotti

2020

Nanobiotechnology in Diagnosis, Drug Delivery, and Treatment

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Concern over indoor fungal growth has increased over the last decades. Research that relates human health issues to the deterioration of indoor air quality due to microbiological pollutants have been accumulated (Rath et al. 2011;Weber 2012;Täubel and Hyvärinen 2015). In addition, since the 1980s, it has been registered that there is an increase in the occurrence of natural disasters such as floods and extreme rainfall, on a global scale, which has enhanced the problems related to biodeterioration in indoor buildings (Bloom et al. 2009;Chow et al. 2019; EASAC 2018). It is worth mentioning that these kinds of events are directly related to fungal growth since water is a key factor in the development of these microorganisms (Johansson et al. 2013;Møller et al. 2017). Considering the strong impact of indoor fungi on public health, several guidelines have been proposed from different European and North American institutions. These institutions include the

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Enhancing Antibacterial Properties and Biocompatibility of Titanium Surfaces through Synergy of Plasma Electrolytic Oxidation and Hydrothermal Process

Mazinani,

Nine,

Rastin

et al. 2024

Adv Eng Mater

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Plasma electrolytic oxidation (PEO) is a well‐established electrochemical method to modify titanium (Ti) surfaces for various industrial applications, including automobile, aerospace, nuclear, sports, defense, and biomedical industries. However, PEO surfaces, with their subsequent nanostructural modification to achieve enhanced antibacterial properties, osseointegration, and biocompatibility on biomedical implants are barely explored. This study investigates the combined approach of PEO and hydrothermal (HT) processes to introduce a range of nanostructures on PEO‐induced porous titania for enhanced antibacterial and improved osseointegration properties. Different fabrication conditions of combined PEO and HT process enabled the fabrication of multidimensional nano‐morphologies, such as blades, needles, belts, and grass that exhibit mechano‐bactericidal properties with enhanced biocompatibility. Antibacterial performance shows that nanostructures generated using HT on the acidic PEO process have excellent antibacterial activity, destroying 88% of E. coli and ≈99% of S. aureus colonies after 24 h incubation. All these fabricated structures show very high biomineralization ability, as confirmed by simulated body fluid (SBF) tests. This study provides valuable contributions showing the potential of low‐cost PEO technology combined with other surface engineering methods for scalable modification and improvements of titanium implants with advanced antibacterial and biointegration properties.

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Nano-structured antimicrobial surfaces: From nature to synthetic analogues

Cited by 306 publications

References 115 publications

Multi-directional electrodeposited gold nanospikes for antibacterial surface applications

Multi-directional electrodeposited gold nanospikes for antibacterial surface applications

Role of Nanotechnology in the Management of Indoor Fungi

Enhancing Antibacterial Properties and Biocompatibility of Titanium Surfaces through Synergy of Plasma Electrolytic Oxidation and Hydrothermal Process

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