Nano‐to‐Macroscale Poly(methyl methacrylate) Stereocomplex Assemblies

Goh, Tor Kit; Tan, Jing; Guntari, Stefanie N.; Satoh, Kotaro; Blencowe, Anton; Kamigaito, Masami; Qiao, Greg G.

doi:10.1002/anie.200903932

Cited by 42 publications

(31 citation statements)

References 41 publications

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“…Examples of PMMA SC‐based assemblies have been reported by the group of Qiao 40. Due to the hydrophobic nature of PMMA, the assemblies were stable in ACN/H 2 O:9/1 but were not tested in pure water, due to their probable lack of stability.…”

Section: Biomedical Applicationsmentioning

confidence: 99%

Emergence of Polymer Stereocomplexes for Biomedical Applications

Bertin

2012

Macro Chemistry & Physics

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Polylactide (PLA) and poly(methyl methacrylate) (PMMA) constitute, already for several decades, the gold standards for various biomedical applications due to their biocompatibility/inertness. Moreover, they have an additional property: they can form stereocomplexes (SCs) that have a more compact crystalline structure than the individual components. As a result, polymer SCs display improved thermal and mechanical properties, as well as delayed drug release and biodegradation rate in the case of drug delivery systems and biomaterials based on PLA, which is of prime importance in the biomedical field. In this article, the potential of SCs for biomedical applications in the areas of drug delivery, tissue engineering, and nanostructured surfaces is highlighted.

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Section: Biomedical Applicationsmentioning

confidence: 99%

Emergence of Polymer Stereocomplexes for Biomedical Applications

Bertin

2012

Macro Chemistry & Physics

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“…1 system. [17] The synthesis of CCS polymer P2 via Cu-catalyzed ATRP using the conventional CuBr/bipyridine (Cat. 2) catalyst system was then explored under comparative conditions.…”

Section: Resultsmentioning

confidence: 99%

Highly Efficient Synthesis of Low Polydispersity Core Cross‐Linked Star Polymers by Ru‐Catalyzed Living Radical Polymerization

Goh

Yamashita

Satoh

et al. 2011

Macromol. Rapid Commun.

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The efficient formation of low polydispersity core cross-linked star (CCS) polymers via controlled/living radical polymerization (LRP) and the arm-first approach was found to be dependent on the mediating catalyst system. The Ru catalyst, Ru(Ind)Cl(PPh₃)₂ Cat. 1, and tertiary amine co-catalyst were used to synthesize highly living poly(methyl methacrylate) (PMMA) macroinitiators, which were then linked together with ethylene glycol dimethacrylate (EGDMA) to form PMMA(arm)PEGDMA(core) CCS polymers. The quantitative and near-quantitative synthesis of CCS polymers were observed for low to moderate molecular weight macroinitiators (M(n) = 8 and 20 kDa), respectively. Lower conversions were observed for high-molecular weight macroinitiators (M(n) ≥ 60 kDa). Overall, an improvement of between 10 and 20% was observed when comparing the Cat. 1 system to a conventional Cu-catalyzed system. This significant improvement in macroinitiator-to-star conversion is explained in the context of catalyst system selection and CCS polymer formation.

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“…A core‐linked star‐shaped polymer consisting of a central crosslinked core and corona arm polymers is regarded as a unimolecular micelle, which shows characteristic features in terms of a high end‐group density and low viscosity compared to its linear analogues . Core‐crosslinked star polymers have been synthesized via various living polymerization, in which linear living polymer chains as the arms react with a small amount of divinyl compounds . Transition metal‐catalyzed atom transfer radical polymerization, which affords polymers with a stable carbon–halogen terminal, has also been utilized for the efficient formation of core‐crosslinked star polymers with a low molecular weight dispersity .…”

Section: Introductionmentioning

confidence: 99%

Synthesis and stereocomplexation of PMMA‐based star polymers prepared by a combination of stereospecific anionic polymerization and crosslinking radical polymerization

Usuki

Okura

Satoh

et al. 2018

J. Polym. Sci. Part A: Polym. Chem.

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Novel star‐shaped polymers with various stereo‐regular arm polymers are synthesized by a combination of stereospecific living anionic polymerization and transition metal‐catalyzed radical linking polymerization, in which the terminal halogen mediates the transformation of the growing active species from a carbanion into a carbon radical. Using this technique, a series of star polymers with isotactic and syndiotactic poly (methyl methacrylate) arms can be prepared with various stereocomplexation behaviors.

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Nano‐to‐Macroscale Poly(methyl methacrylate) Stereocomplex Assemblies

Cited by 42 publications

References 41 publications

Emergence of Polymer Stereocomplexes for Biomedical Applications

Emergence of Polymer Stereocomplexes for Biomedical Applications

Highly Efficient Synthesis of Low Polydispersity Core Cross‐Linked Star Polymers by Ru‐Catalyzed Living Radical Polymerization

Synthesis and stereocomplexation of PMMA‐based star polymers prepared by a combination of stereospecific anionic polymerization and crosslinking radical polymerization

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