“Nanoantibiotics”: A new paradigm for treating infectious diseases using nanomaterials in the antibiotics resistant era

Huh, Ae Jung; Kwon, Young Jik

doi:10.1016/j.jconrel.2011.07.002

Cited by 1,632 publications

(1,170 citation statements)

References 269 publications

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“…With the emergence of pathogenic bacterial strains that possess a resistance toward one or several antibiotics, the medical world is in need of new classes of disinfection systems [1][2][3][4][5]. Silver-containing systems, and notably silver nanoparticles (Ag NPs) are to these days one of the most promising system to fill this role [6][7][8].…”

Section: Introductionmentioning

confidence: 99%

Antibacterial activity of silver nanoparticles: A surface science insight

2015

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Summary Silver nanoparticles constitute a very promising approach for the development of new antimicrobial systems. Nanoparticulate objects can bring significant improvements in the antibacterial activity of this element, through specific effect such as an adsorption at bacterial surfaces. However, the mechanism of action is essentially driven by the oxidative dissolution of the nanoparticles, as indicated by recent direct observations. The role of Ag + release in the action mechanism was also indirectly observed in numerous studies, and explains the sensitivity of the antimicrobial activity to the presence of some chemical species, notably halides and sulfides which form insoluble salts with Ag + . As such, surface properties of Ag nanoparticles have a crucial impact on their potency, as they influence both physical (aggregation, affinity for bacterial membrane, etc.) and chemical (dissolution, passivation, etc.) phenomena. Here, we review the main parameters that will affect the surface state of Ag NPs and their influence on antimicrobial efficacy. We also provide an analysis of several works on Ag NPs activity, observed through the scope of an oxidative Ag + release.

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Section: Introductionmentioning

confidence: 99%

Antibacterial activity of silver nanoparticles: A surface science insight

2015

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“…One of the most promising strategies for overcoming microbial resistance is the use of nanoparticles (NP)8,9. Several classes of antimicrobial NPs and nanosized carriers for antibiotics delivery have proven their effectiveness for treating infectious diseases, including antibiotic-resistant ones 3,4,8,10 .…”

Section: ■ Introductionmentioning

confidence: 99%

Oxacillin magnetically targeted for the treatment of Methicillin-Resistant S. aureus infection in rats

et al. 2017

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Purpose: To evaluate the effect of oxacillin bonded to magnetic nanoparticles in local infection model in rat. Methods: Twelve Wistar rats weighing 290±18g were randomly divided into four groups (n=6, each) and all rats had a magnet ring sutured on their right thighs. In the biodistribution group rats 0.1mL of 99m Tc-magnetite (0.66 MBq) was injected i.v and after 30 minutes, biodistribution of 99m Tc-magnetite was evaluated in right and left thighs. The other groups were inoculated with MRSA in each thigh muscles. Group 1 rats were injected i.v. with magnetite, group 2 with Magnetite + Oxacillin, group 3 with saline twice a day. After 24 hours samples of muscle secretion were harvested for microbiological analysis; muscle, lungs and kidneys for histology. Results: 99m Tc-magnetite uptake was three-fold higher in right thigh muscles (with external magnet) than in the left. In magnetite and oxacillin-magnetite groups, bacterial/CFU was significantly lower in thigh muscles than in saline-controls. The inflammatory reaction in muscles and lungs was significantly lower in oxacillin-magnetite group-rats than in other groups (p<0.001). Conclusion: This study confirms the potential antimicrobial activity of magnetic nanoparticles for Methicillin-Resistant S. aureus strains, which in addition to concentrate the antibiotic at the infection site, positively influenced the treatment.

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“…The primary advantage of such antibacterial coatings is the release of the antibacterial agent at the site of implantation, minimizing the risk of concentrations being reached that could cause harmful side effects in other parts of the body. Recently, nontraditional antibiotic agents have been of tremendous interest in overcoming resistance that is developed by several pathogenic microorganisms against most of the commonly used antibiotics [8,9]. Especially, silver nanoparticles have proven their effectiveness for preventing bacterial adhesion and biofilm formation [10].…”

Section: Introductionmentioning

confidence: 99%

“…Zinc oxide nanoparticles are proposed as another metallic component of antibacterial properties. They are believed to destruct lipids and proteins of the bacterial cell membrane, resulting in a leakage of intracellular contents and eventually the death of bacterial cells [8]. ZnOenriched surfaces are capable to inhibit the growth of bacteria [11].…”

Section: Introductionmentioning

confidence: 99%

Antibacterial Composite Layers on Ti: Role of ZnO Nanoparticles

Roguska¹,

Belcarz²,

Suchecki³

et al. 2016

Archives of Metallurgy and Materials

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Problem of post-operative infections of implant materials caused by bacterial adhesion to their surfaces is very serious. Enhancement of antibacterial properties is potentially beneficial for biomaterials value. Therefore, the metallic and metallic oxide nanoparticles attract particular attention as antimicrobial factors. The aim of this work was to create nanotubular (NT) oxide layers on Ti with the addition of ZnO nanoparticles, designed for antibacterial biomedical coatings. Antimicrobial activities of titanium, TiO 2 NT and ZnO/TiO 2 NT surfaces were evaluated against bacterial strain typical for orthopaedic infections: S. epidermidis. TiO 2 NT alone killed the free bacterial cells significantly but promoted their adhesion to the surfaces. The presence of moderate amount of ZnO nanoparticles significantly reduced the S. epidermidis cells adhesion and viability of bacterial cells in contact with modified surfaces. However, higher amount of loaded nanoZnO showed the reduced antimicrobial properties than the medium amount, suggesting the overdose effect.

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“Nanoantibiotics”: A new paradigm for treating infectious diseases using nanomaterials in the antibiotics resistant era

Cited by 1,632 publications

References 269 publications

Antibacterial activity of silver nanoparticles: A surface science insight

Antibacterial activity of silver nanoparticles: A surface science insight

Oxacillin magnetically targeted for the treatment of Methicillin-Resistant S. aureus infection in rats

Antibacterial Composite Layers on Ti: Role of ZnO Nanoparticles

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