Nanoantioxidant–Based Silica Particles as Flavonoid Carrier for Drug Delivery Applications

Arriagada, Francisco; Günther, Germán; Morales, Javier

doi:10.3390/pharmaceutics12040302

Cited by 30 publications

(23 citation statements)

References 76 publications

(107 reference statements)

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“…The encapsulation of RA in drug nanocarriers is a promising option for increasing the therapeutical performance of RA because the longer circulation times achieved in blood allow prolonged biological activity and a greater probability of accumulating in inflamed tissues, in which vascular permeability is increased [ 16 ]. With these purposes in mind, RA has been loaded or encapsulated in solid lipid nanoparticles [ 14 , 17 , 18 ], natural [ 15 , 19 , 20 , 21 ] or synthetic [ 16 , 22 ] polymer nanoparticles and inorganic nanoparticles [ 23 ]. Among the different approaches explored to date, nanoparticles based on biopolymers are of particular interest as drug nanocarriers because they are biodegradable, natural and environmentally-friendly [ 24 , 25 ].…”

Section: Introductionmentioning

confidence: 99%

Antitumor Activity of Rosmarinic Acid-Loaded Silk Fibroin Nanoparticles on HeLa and MCF-7 Cells

et al. 2021

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Rosmarinic acid (RA), one of the most important polyphenol-based antioxidants, has drawn increasing attention because of its remarkable bioactive properties, including anti-inflammatory, anticancer and antibacterial activities. The aim of this study was to synthesize and characterize RA-loaded silk fibroin nanoparticles (RA-SFNs) in terms of their physical–chemical features and composition, and to investigate their antitumor activity against human cervical carcinoma and breast cancer cell lines (HeLa and MCF-7). Compared with the free form, RA bioavailability was enhanced when the drug was adsorbed onto the surface of the silk fibroin nanoparticles (SFNs). The resulting particle diameter was 255 nm, with a polydispersity index of 0.187, and the Z-potential was −17 mV. The drug loading content of the RA-SFNs was 9.4 wt.%. Evaluation of the in vitro drug release of RA from RA-SFNs pointed to a rapid release in physiological conditions (50% of the total drug content was released in 0.5 h). Unloaded SFNs exhibited good biocompatibility, with no significant cytotoxicity observed during the first 48 h against HeLa and MCF-7 cancer cells. In contrast, cell death increased in a concentration-dependent manner after treatment with RA-SFNs, reaching an IC50 value of 1.568 and 1.377 mg/mL on HeLa and MCF-7, respectively. For both cell lines, the IC50 of free RA was higher. The cellular uptake of the nanoparticles studied was increased when RA was loaded on them. The cell cycle and apoptosis studies revealed that RA-SFNs inhibit cell proliferation and induce apoptosis on HeLa and MCF-7 cell lines. It is concluded, therefore, that the RA delivery platform based on SFNs improves the antitumor potential of RA in the case of the above cancers.

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Section: Introductionmentioning

confidence: 99%

Antitumor Activity of Rosmarinic Acid-Loaded Silk Fibroin Nanoparticles on HeLa and MCF-7 Cells

et al. 2021

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“…Thus, efforts to improve the bioavailability of flavonoids focus mainly on increasing their intestinal absorption [ 108 , 109 ]. The research has evolved from classical drug absorption enhancers like the borneol/methanol mixture [ 112 ] to complicated nano-delivery systems, and even nanoantioxidant flavonoid carriers [ 113 ]. In the meantime, consistent progress is also being made in the field of flavonoid extraction [ 114 ].…”

Section: Flavonoid Bioavailability–can It Be Enhanced?mentioning

confidence: 99%

The Effects of Flavonoids in Cardiovascular Diseases

et al. 2020

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Flavonoids are metabolites of plants and fungus. Flavonoid research has been paid special attention to in recent times after the observation of their beneficial effects on the cardiovascular system. These favorable effects are exerted by flavonoids mainly due to their antioxidant properties, which result from the ability to decrease the oxidation of low-density lipoproteins, thus improving the lipid profiles. The other positive effect exerted on the cardiovascular system is the ability of flavonoids to produce vasodilation and regulate the apoptotic processes in the endothelium. Researchers suggested that these effects, including their anti-inflammatory function, are consequences of flavonoids’ potent antioxidant properties, but recent studies have shown multiple signaling pathways linked to them, thus suggesting that there are more mechanisms involved in the beneficial effect of the flavonoids on the human body. This review aims to present the latest data on the classification of these substances, their main mechanisms of action in the human body, and the beneficial effects on the physiological and pathological status of the cardiovascular system.

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“…[115] Curcumin [116] Eugenol [112] Fenugreek (seed absolut) [117] Gallic acid [118] Hydrolyzed spent coffee grounds [119] Lemongrass E.O. [120] Mango (extract) [121,122] Melanin [123] Moringa oleifera (extract) [109] Quercetin [113,124,125] Rosmarinic acid [126] Rosemary (extract) [127] Tannic acid [128,129] Teucrium polium (extract) [130] Thyme (polyphenol extract) [131] Thymol [132] Vitamin C [133] Cellulose-PEG [120] CH [112,113,122,132] CH-derivates [118,131] CH-gum [115] HA [129] Halloyste [124] Magnesium alloy [128] P(3HB-co-3HV) [133] PDMS [ [117] SF [123] Silica [111,126] Silica-PEG [114] Indirect antioxidant effects (including cytoprotection)…”

Section: Scavenging Activitymentioning

confidence: 99%

“…[165] Plumbagin [159] Rosemary (extract) [127] Sesamol [166] Soybean (oil) [167] Thymus (polyphenol extract) [168] Zataria Multiflora E.O. [169] Cellulose acetate-gelatin [162] CH [168] Collagen [159,161] Gelatin derivates-collagen [158] HPG [164] PA-6 [167] PCL [48,100,165] PCL-gum [163] PEG-ALG [109] PLA [127,166] PLA-derivatives [152] PVA derivates [169] Controlled release Astaxanthin [170][171][172] Caffeic acid [173] Curcumin [116,[174][175][176] Cystamine [73] EGCG [177,178] Morin [126] Ostholamide [158] Quercetin [157] Rosmarinic acid [179] Sage E.O. [180] Thymol [181] Thymus (polyphenol extract) [168] ALG [170,177] CH-derivates [116,171] CH [168,…”

Section: Hydrophilicity and Wettability/swellingmentioning

confidence: 99%

“…[169] Cellulose acetate-gelatin [162] CH [168] Collagen [159,161] Gelatin derivates-collagen [158] HPG [164] PA-6 [167] PCL [48,100,165] PCL-gum [163] PEG-ALG [109] PLA [127,166] PLA-derivatives [152] PVA derivates [169] Controlled release Astaxanthin [170][171][172] Caffeic acid [173] Curcumin [116,[174][175][176] Cystamine [73] EGCG [177,178] Morin [126] Ostholamide [158] Quercetin [157] Rosmarinic acid [179] Sage E.O. [180] Thymol [181] Thymus (polyphenol extract) [168] ALG [170,177] CH-derivates [116,171] CH [168,180] Gelatin [178] Gelatin derivates-collagen [158] PBAE [73,176] PCL [175] Porcine pericardium (decellularized) [157] PVA <...>…”

Section: Hydrophilicity and Wettability/swellingmentioning

confidence: 99%

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Repositioning Natural Antioxidants for Therapeutic Applications in Tissue Engineering

Marrazzo

O’Leary

2020

Bioengineering

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Although a large panel of natural antioxidants demonstrate a protective effect in preventing cellular oxidative stress, their low bioavailability limits therapeutic activity at the targeted injury site. The importance to deliver drug or cells into oxidative microenvironments can be realized with the development of biocompatible redox-modulating materials. The incorporation of antioxidant compounds within implanted biomaterials should be able to retain the antioxidant activity, while also allowing graft survival and tissue recovery. This review summarizes the recent literature reporting the combined role of natural antioxidants with biomaterials. Our review highlights how such functionalization is a promising strategy in tissue engineering to improve the engraftment and promote tissue healing or regeneration.

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Nanoantioxidant–Based Silica Particles as Flavonoid Carrier for Drug Delivery Applications

Cited by 30 publications

References 76 publications

Antitumor Activity of Rosmarinic Acid-Loaded Silk Fibroin Nanoparticles on HeLa and MCF-7 Cells

Antitumor Activity of Rosmarinic Acid-Loaded Silk Fibroin Nanoparticles on HeLa and MCF-7 Cells

The Effects of Flavonoids in Cardiovascular Diseases

Repositioning Natural Antioxidants for Therapeutic Applications in Tissue Engineering

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