Nanoarchitectonics in Cancer Therapy and Imaging Diagnosis

Pandey, Abhijeet; Girase, Nayandip M; Patil, Mahendra D; Patil, Pravin O.; Patil, Dilip A.; Deshmukh, Prashant K.

doi:10.1166/jnn.2014.9014

Cited by 33 publications

(14 citation statements)

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“…This concept, named ''nanoarchitectonics'', was introduced by Aono in 2000 [4][5][6][7][8]. The application of nanoarchitechtonics in nanomaterials [9][10][11], biological interfaces [12][13][14][15][16][17][18], and other applications [19][20][21][22] have been reported. At the same period, the layer-by-layer (LbL) assembly of films, membranes and capsules has undergone tremendous development, allowing the incorporation of an unprecedented range of functional building blocks into macromolecular platforms [23,24].…”

Section: Introductionmentioning

confidence: 99%

Electrochemical nanoarchitectonics and layer-by-layer assembly: From basics to future

et al. 2015

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No. of Pages 30 2 G. Rydzek et al. SummaryDuring the last few decades, electrochemistry and electrode modification have seen a tremendous fall off in creativity with the emergence of the nanoarchitectonic-based layerby-layer (LbL) film deposition technique. An unprecedented variety of building blocks can be immobilized on surfaces, leading to progress in several fields including sensing, electrochromic, electro-responsive and energy devices. This review describes the state of the art of electrochemical devices based on LbL assemblies, with a focus on supercapacitors, biosensors, and electroresponsive LbL such as electrodissolution/electroswelling of coatings. Recently, electrochemistry has also been used as an ''active trigger'' to induce the formation of films by covalent coupling, leading to new nanoarchitectonic approaches beyond the LbL strategy. These emerging electro-coupling reactions, including electroclick and carbazole chemistry, open new perspectives toward architecture and patterning of functional films and are extensively reviewed.

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Section: Introductionmentioning

confidence: 99%

Electrochemical nanoarchitectonics and layer-by-layer assembly: From basics to future

et al. 2015

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“…In recent years, the benefits of small molecule drugs have been significantly enhanced via the nanomedicine approach where the drug molecules are packaged within nanovehicles that keep the drug incirculation for longer periods of time (by preventing renal clearance and non‐specific uptake) and allow increased uptake within the tumors based on EPR (enhanced permeability and retention) effects . Fullerene(C60), the third allotrope of carbon after diamond and graphite, is a nanoscale carbon material with unique photo‐, electro‐chemical, and physical‐properties, however, its inherent hydrophobicity limits use in biology and thus lead to its search in searching water‐soluble fullerene derivatives .…”

Section: Introductionmentioning

confidence: 99%

5‐Aminolevulinic acid‐Loaded Fullerene Nanoparticles for In Vitro and In Vivo Photodynamic Therapy

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Zhang

et al. 2014

Photochem & Photobiology

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This report explores some properties of 80-200 nm nanoparticles containing 5-aminolevulinic acid (ALA) and fullerene (C60) for photodynamic therapy (PDT). Compared with ALA, the nanoparticles yielded more protoporphyrin IX (PpIX) formation in cells and tissues and to a significant improvement in antitumor efficacy in tumor-bearing mice. Maximum levels of PpIX were obtained 4 h after administration and selective PpIX formation in tumor was observed. These nanoparticles appear to be a useful vehicle for drug delivery purposes. In this study, a procedure for preparing fullerene nanoparticles containing ALA was developed. The product alone exhibited no detectable toxicity in the dark and was superior to ALA alone in promoting PpIX biosynthesis and PDT efficacy both in culture and in a murine tumor model. These results suggest that this procedure could be the basis for an improved PDT protocol for cancer control.

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“…DNA nanobots [34], quantum dots [35]) for reporting disease status and selectively delivering drugs to tumour cells whilst minimising systemic side effects [36].…”

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confidence: 99%