Nanoarchitectonics of a MOF-in-Nanochannel (HKUST-1/TiO₂) Membrane for Multitarget Selective Enrichment and Staged Recovery

Abstract

Enrichment and separation of specific endogenous molecules are essential for disease diagnosis and the pharmaceutical industry. Although many solid sorbents have been developed for target molecule enrichment, simultaneous separation of multitargets is still a challenge for adsorbents. In this study, we develop a multitarget selective sorbent based on a nanochannel membrane prepared by the anodization of a Ti−Cu alloy. The in situ growth of a metal− organic framework (MOF, herein using Cu-based HKUST-1) in the nanochannels enables the resulting MOF-in-nanochannel membrane to act as a nanofilter. Benefitting from the size-exclusion effect of MOFs and the distinct surface characteristics of each component in the HKUST-1/TiO 2 nanochannels, the asproposed membranes can be simply operated as a filter and exhibit satisfactory selectivities and enrichment capacities in the separation of aromatic amino acids, histidine-rich proteins, and phosphoproteins. More importantly, the adsorbed multitargets can be further controllably released from the membrane in a sequence via a staged recovery process. The use of this system is envisioned to provide an innovative and potential design for efficient sorption media for the selective enrichment and staged separation of specific biomolecules.

Copper ion based metal–organic framework nanomaterials with roughness enhanced protein adhesion for high-efficiency hemoglobin separation

“…The equilibrium data are more consistent with the Langmuir model and exhibit a higher correlating constant (R 2 ), manifesting that BHb could be absorbed by Cu-MOF in a monolayer adsorption manner. Meanwhile, compared to those of previously reported MOF-based BHb absorbents, 19,33,35,[48][49][50] Cu-MOF exhibits superior performance with higher adsorption capacity in the adsorption time of 60 min (Table S2 and Fig. S8, ESI †).…”

Metal–Organic Framework-Decorated Nanochannel Electrode: Integration of Internal Nanoconfined Space and Outer Surface for Small-Molecule Sensing

“…The growth difference of ZIF-8 in channels with different sizes can be attributed to the limited growth of MOF crystals in the nanoconfined space. 43 It was also observed that the load of ZIF-8 crystals significantly decreased along the channel from the Zn(II) addition side to the 2-methylimidazole (2-Mlm) addition side, resulting from the concentration gradient of precursors (Figure S4). More importantly, only the pore size of ZIF-8/INCE with a pristine AAO size of 28 nm approached several nanometers, which enabled significant nanoconfinement as proven later, indicating that this method may be promising to construct a nanogap for various applications.…”

“…Clearly, the smaller the pristine pore size of AAO, the larger the decrease degree of the pore size due to the deposition of MOFs. The growth difference of ZIF-8 in channels with different sizes can be attributed to the limited growth of MOF crystals in the nanoconfined space . It was also observed that the load of ZIF-8 crystals significantly decreased along the channel from the Zn­(II) addition side to the 2-methylimidazole (2-Mlm) addition side, resulting from the concentration gradient of precursors (Figure S4).…”

Sustainable and Well-Dispersed Cu-Doped Magnetic Vortex Nanorings for Highly Specific Separation of His-Rich Proteins

“…These problems ultimately lead to low adsorption performance and environmental pollution, which restrict their practical application. As an alternative strategy, magnetic composites incorporating the metal–organic framework (MOF), , layered double hydroxide (LDH), , and montmorillonite , are also reported for the separation of histidine-rich proteins. Despite the success of the aforementioned strategy in resolving the defects of ligand-based magnetic IMA adsorbents, there is a trade-off between magnetism and adsorption performance.…”