Nanoarchitectonics on living cells

Ariga, Katsuhiko; Fakhrullin, Rawil

doi:10.1039/d1ra03424c

Cited by 28 publications

(12 citation statements)

References 214 publications

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“…LbL assembly using bioactive components and interactive components (polymers in most cases) can be used as a promising method for multilayer-type nanoarchitectonics of biomimetic and biological components. Based on this strategy, multilayer nanoarchitectures can be fabricated on living cells [ 131 ], and even living cells can be used as components of multilayer nanoarchitectures. As explained in a recent review article by Akashi and Akagi [ 132 ], LbL assemblies of living cells are capable of forming functional three-dimensional tissues, which can be used as three-dimensional skin models and three-dimensional heart models.…”

Section: Self-assembly Nanoarchitectonics With Bio-related Units Generalmentioning

confidence: 99%

Biomimetic and Biological Nanoarchitectonics

Ariga

2022

IJMS

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A post-nanotechnology concept has been assigned to an emerging concept, nanoarchitectonics. Nanoarchitectonics aims to establish a discipline in which functional materials are fabricated from nano-scale components such as atoms, molecules, and nanomaterials using various techniques. Nanoarchitectonics opens ways to form a more unified paradigm by integrating nanotechnology with organic chemistry, supramolecular chemistry, material chemistry, microfabrication technology, and biotechnology. On the other hand, biological systems consist of rational organization of constituent molecules. Their structures have highly asymmetric and hierarchical features that allow for chained functional coordination, signal amplification, and vector-like energy and signal flow. The process of nanoarchitectonics is based on the premise of combining several different processes, which makes it easier to obtain a hierarchical structure. Therefore, nanoarchitectonics is a more suitable methodology for creating highly functional systems based on structural asymmetry and hierarchy like biosystems. The creation of functional materials by nanoarchitectonics is somewhat similar to the creation of functional systems in biological systems. It can be said that the goal of nanoarchitectonics is to create highly functional systems similar to those found in biological systems. This review article summarizes the synthesis of biomimetic and biological molecules and their functional structure formation from various viewpoints, from the molecular level to the cellular level. Several recent examples are arranged and categorized to illustrate such a trend with sections of (i) synthetic nanoarchitectonics for bio-related units, (ii) self-assembly nanoarchitectonics with bio-related units, (iii) nanoarchitectonics with nucleic acids, (iv) nanoarchitectonics with peptides, (v) nanoarchitectonics with proteins, and (vi) bio-related nanoarchitectonics in conjugation with materials.

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Section: Self-assembly Nanoarchitectonics With Bio-related Units Generalmentioning

confidence: 99%

Biomimetic and Biological Nanoarchitectonics

Ariga

2022

IJMS

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“…Its application in neural repair is a topic of great interest. Nanoencapsulation uses an ultrathin external structure (<100 nm) to encapsulate viable cells or factors ( Ariga and Fakhrullin, 2021 ). External materials come from a wide range of sources, such as polymers, hydrogels, and minerals ( Lee H. et al, 2021 ).…”

Section: Novel Materialsmentioning

confidence: 99%

Donors for nerve transplantation in craniofacial soft tissue injuries

Sun

Zhong

et al. 2022

Front. Bioeng. Biotechnol.

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Neural tissue is an important soft tissue; for instance, craniofacial nerves govern several aspects of human behavior, including the expression of speech, emotion transmission, sensation, and motor function. Therefore, nerve repair to promote functional recovery after craniofacial soft tissue injuries is indispensable. However, the repair and regeneration of craniofacial nerves are challenging due to their intricate anatomical and physiological characteristics. Currently, nerve transplantation is an irreplaceable treatment for segmental nerve defects. With the development of emerging technologies, transplantation donors have become more diverse. The present article reviews the traditional and emerging alternative materials aimed at advancing cutting-edge research on craniofacial nerve repair and facilitating the transition from the laboratory to the clinic. It also provides a reference for donor selection for nerve repair after clinical craniofacial soft tissue injuries. We found that autografts are still widely accepted as the first options for segmental nerve defects. However, allogeneic composite functional units have a strong advantage for nerve transplantation for nerve defects accompanied by several tissue damages or loss. As an alternative to autografts, decellularized tissue has attracted increasing attention because of its low immunogenicity. Nerve conduits have been developed from traditional autologous tissue to composite conduits based on various synthetic materials, with developments in tissue engineering technology. Nerve conduits have great potential to replace traditional donors because their structures are more consistent with the physiological microenvironment and show self-regulation performance with improvements in 3D technology. New materials, such as hydrogels and nanomaterials, have attracted increasing attention in the biomedical field. Their biocompatibility and stimuli-responsiveness have been gradually explored by researchers in the regeneration and regulation of neural networks.

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“…The promising behavior of these nanoscale particles promotes applications in biomedicines with enhanced utilization as both therapeutic and diagnostic agents via nanoarchitectonics. 1,2 Nanoscale structures are created to achieve hierarchical structures through biomolecular interactions such as hydrophobic/hydrophilic, π-π, and other interactions. 3 A significant number of these nanoformulations comprise drug conjugates and complexes, dendrimers, vesicles, micelles, core-shell particles, and carbon nanotubes designed to carry off drugs or contrast agents.…”

Section: Introductionmentioning

confidence: 99%