Nanoarchitecture-based photothermal ablation of cancer: A systematic review

Malekzadeh, Reza; Mortezazadeh, Tohid; Abdulsahib, Waleed K.; Abdollahi, Behnaz Babaye; Hamblin, Michael R.; Mansoori, Behzad; Alsaikhan, Fahad; Zeng, Beibei

doi:10.1016/j.envres.2023.116526

Cited by 17 publications

(3 citation statements)

References 161 publications

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“…With the advent of nanotechnology, there has been a renewed interest in the application of phototherapy for cancer treatment specially using near infrared activated nanomaterials [11,12]. The development of multifunctional nanoagents that can actualize a combination of PDT or PTT with chemotherapy and immunotherapy within the same platform, offers great promise for treatment of TNBC [13][14][15]. There have been several recent studies exploring this at in vitro and in vivo scale with particular focus on transition metal-based oxides and sulfides [16][17][18].…”

Section: Introductionmentioning

confidence: 99%

Tumor targeted nanohybrid for dual stimuli responsive and NIR amplified photothermal/photo-induced thermodynamic/chemodynamic combination therapy

Mehrotra,

Pal

2024

Biomed. Mater.

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The combination of photodynamic (PDT) and chemodynamic therapy (CDT) for cancer treatment has gathered a lot of attention in recent years. However, its efficacy is severely limited by elevated levels of hypoxia and glutathione (GSH) in the tumor microenvironment (TME). Multifunctional nanoparticles that can help remodel the TME while facilitating PDT/CDT combination therapy are the need of the hour. To this effect, we have developed O2 self-supplying, free radical generating nanohybrids that exhibit NIR triggered photothermal (PTT)/photo-induced thermodynamic (P-TDT) and chemodynamic therapy for efficient breast cancer treatment. The surface of nanohybrids has been further modified by biointerfacing with cancer cell membrane. The biomimetic nanohybrids have been comprehensively characterized and found to exhibit high AIPH loading, glutathione depletion, oxygen self-supply with tumor microenvironment responsive AIPH release. Biological activity assays demonstrate efficient cellular uptake with homotypic targeting, excellent hemo- and cytocompatibility as well as high intracellular reactive oxygen species generation with synergistic cytotoxicity against tumor cells. The multifunctional nanohybrid proposed in the present study provides an attractive strategy for achieving NIR responsive, tumor targeted PTT/P-TDT/CDT combination therapy for breast cancer treatment.

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Section: Introductionmentioning

confidence: 99%

Tumor targeted nanohybrid for dual stimuli responsive and NIR amplified photothermal/photo-induced thermodynamic/chemodynamic combination therapy

Mehrotra,

Pal

2024

Biomed. Mater.

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“…The effect of PPT is based on local hyperthermia of tissues induced by the plasmonic nanoparticles, which are accumulated in tumors. Among various plasmonic heaters, gold nanorods (GNRs) have great potential for use in PPT treatment [3][4][5]. The increase in the number of publications associated with the development of PPT using various nanoparticles and excitation wavelengths in the NIR region is caused by its spatiotemporal selectivity, high sensitivity, fewer side effects, least invasiveness, fast and effective treatment, and low cost [3].…”

Section: Introductionmentioning

confidence: 99%

Monitoring of optical properties of tumors during laser plasmon photothermal therapy

Genin,

Bucharskaya,

Kirillin

et al. 2024

Journal of Biophotonics

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We studied grafted tumors obtained by subcutaneous implantation of kidney cancer cells into male white rats. Gold nanorods with a plasmon resonance of about 800 nm were injected intratumorally for photothermal heating. Experimental irradiation of tumors was carried out percutaneously using a near‐infrared diode laser. Changes in the optical properties of the studied tissues in the spectral range 350–2200 nm under plasmonic photothermal therapy (PPT) were studied. Analysis of the observed changes in the absorption bands of water and hemoglobin made it possible to estimate the depth of thermal damage to the tumor. A significant decrease in absorption peaks was observed in the spectrum of the upper peripheral part and especially the tumor capsule. The obtained changes in the optical properties of tissues under laser irradiation can be used to optimize laboratory and clinical PPT procedures.

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“…Nanoparticles (NPs) with high atomic numbers have shown great promise in delivering therapeutic agents to cancer cells, thereby enhancing localized energy transfer to the tumor. NPs serve as effective carriers for drug delivery, improving targeted delivery to tumor cells [4]. Moreover, NPs offer additional advantages, such as modulating the cell cycle, generating reactive oxygen species (ROS), triggering in ammatory responses, causing harm to genetic material, and inducing cell death [5].…”

Section: Introductionmentioning

confidence: 99%

Radio-photodynamic therapy capability of advanced Au@ALA nanocluster in breast cancer treatment

Talaee,

Faghihi,

Rastegari

et al. 2024

Preprint

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Purpose The purpose of current study was to assess the impact of ALA-coated gold nanoclusters (Au NPs) on the combined therapeutic effects of radiotherapy (RT) and photodynamic therapy (PDT) on healthy MCF-10A and MCF-7 breast cancer cells. Methods The Au NPs were covered with ALA using PEG polymer, resulting in the synthesis of Au@ALA NPs. The successful synthesis of the final NPs was confirmed through FTIR, XRD, TEM, and UV-Vis tests. MCF-10A and MCF-7 cell lines were treated with different concentrations of Au@ALA NPs and exposed to irradiation of 2 and 4 Gy (using MV X-ray) and 630 nm laser light irradiation. Cytotoxicity was assessed using the MTT method. Results The findings revealed that the damage inflicted by Au@ALA NPs on cancerous tissue was significantly greater than that on normal tissue. The cytotoxic effects of all experimental groups exhibited a direct correlation with increasing concentrations and radiation doses. The combination of Au@ALA NPs with RT doses of 2 and 4 Gy resulted in a reduction in cell viability by a factor of 1.58 (P = 0.001) and 1.73 (P = 0.004), respectively. Furthermore, the simultaneous intervention of NPs with PDT and RT at doses of 2 and 4 Gy led to a decrease in cell viability by a factor of 2.10 (P = 0.001) and 3.08 (P = 0.001) in turn. Conclusion The concurrent application of Au@ALA NPs in RT and PDT successfully enhanced the radiosensitization of breast cancer cells to megavoltage RT and PDT.

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Nanoarchitecture-based photothermal ablation of cancer: A systematic review

Cited by 17 publications

References 161 publications

Tumor targeted nanohybrid for dual stimuli responsive and NIR amplified photothermal/photo-induced thermodynamic/chemodynamic combination therapy

Tumor targeted nanohybrid for dual stimuli responsive and NIR amplified photothermal/photo-induced thermodynamic/chemodynamic combination therapy

Monitoring of optical properties of tumors during laser plasmon photothermal therapy

Radio-photodynamic therapy capability of advanced Au@ALA nanocluster in breast cancer treatment

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