Nanobased Intravenous and Transdermal Drug Delivery Systems

Rathna, G. V. N.; Singam, Amarnath; Killi, Naresh

doi:10.1016/b978-0-12-814029-1.00019-3

Cited by 21 publications

(7 citation statements)

References 133 publications

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“…Solvent evaporation is a prominent method used for the preparation of biodegradable nanoparticles. According to Gundloori et al (2019), the technique involves emulsifying polymer in an aqueous phase and dispersion in a volatile solvent such as chloroform, dichloromethane, or ethyl acetate. The authors further stated that the nanoparticles are produced by evaporating the solvent using a high-temperature vacuum or continuous stirring.…”

Section: Solvent Evaporation Methodsmentioning

confidence: 99%

Chitosan Nanocomposites as Wound Healing Materials: Advances in Processing Techniques and Mechanical Properties

Dele‐Afolabi¹,

Ariff²,

Ojo-Kupoluyi³

et al. 2022

JST

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This review discusses the increasing potential of chitosan nanocomposites as viable materials capable of targeting these debilitating factors. This review focuses on various techniques used to process chitosan nanocomposites and their mechanical properties. Chitosan nanocomposites are regarded as highly effective antimicrobials for the treatment of chronic wounds. Chitosan nanocomposites, such as chitosan/polyethylene and oxide/silica/ciprofloxacin, demonstrate efficient antibacterial activity and exhibit no cytotoxicity against Human Foreskin Fibroblast Cell Lines (HFF2). Other studies have also showcased the capacity of chitosan nanocomposites to accelerate and improve tissue regeneration through increment in the number of fibroblast cells and angiogenesis and reduction of the inflammation phase. The layer-by-layer technique has benefits, ensuring its suitability in preparing chitosan nanocomposites for drug delivery and wound dressing applications. While the co-precipitation route requires a cross-linker to achieve stability during processing, the solution-casting route can produce stable chitosan nanocomposites without a cross-linker. By using the solution casting method, fillers such as multi-walled carbon nanotubes (MWCNTs) and halloysite nanotubes (HTs) can be uniformly distributed in the chitosan, leading to improved mechanical properties. The antibacterial effects can be achieved with the introduction of AgNPs or ZnO. With the increasing understanding of the biological mechanisms that control these diseases, there is an influx in the introduction of novel materials into the mainstream wound care market.

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Section: Solvent Evaporation Methodsmentioning

confidence: 99%

Chitosan Nanocomposites as Wound Healing Materials: Advances in Processing Techniques and Mechanical Properties

Dele‐Afolabi¹,

Ariff²,

Ojo-Kupoluyi³

et al. 2022

JST

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“…Ongoing research and innovation in this field are likely to unveil new applications and further amplify its impact in the years to come. This article aims to provide a comprehensive overview of the multifaceted impact of nanofiber technology, emphasizing its role in reshaping pharmaceuticals, materials science, diagnostics, environmental solutions, and beyond [2][3][4][5] .…”

Section: ~ 2 ~mentioning

confidence: 99%

Untitled

2024

Nat. J. Pharm. Sci.

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This article delves into the transformative potential of nanofiber technology in pharmaceuticals and its profound impact on healthcare. Nanofibers, with their unique properties, are revolutionizing drug delivery systems, wound healing, and diagnostic applications. The versatility of nanofibers allows for precise control over drug release, enabling targeted therapies and personalized medicine. Examples include nanofiber wound dressings that expedite healing and drug delivery systems with enhanced efficacy and reduced side effects. The integration of nanofibers with biosensors facilitates sensitive and rapid diagnostics, paving the way for early disease detection. Furthermore, nanofibers play a pivotal role in tissue engineering, creating scaffolds that mimic the natural extracellular matrix and support tissue regeneration. This has implications for regenerative medicine, offering innovative solutions for bone, nerve, and dental tissue regeneration. The article emphasizes the potential of nanofiber applications in neural interfaces, respiratory protection, and even space exploration. While highlighting successful case studies and breakthroughs, the article addresses challenges like regulatory considerations, scalability issues, and biocompatibility concerns. It emphasizes the need for collaborative efforts between researchers, industry stakeholders, and regulatory bodies to overcome these challenges. The transformative impact of nanofibers extends to improved treatment outcomes, enhanced patient care, and increased efficiency in healthcare delivery. The narrative underscores the significance of ongoing research, encouraging exploration in this dynamic field. As nanofiber technology continues to evolve, it holds the promise of shaping a future where healthcare is personalized, efficient, and marked by innovative solutions that significantly improve the well-being of patients.

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“…Among the processing techniques, including thermal‐induced phase separation, drawing, template synthesis, and self‐assembly, electrospinning is of considerable significance as a rapidly evolving fiber preparation method. [ 52 ] This highly versatile method is used to process solutions, suspensions, or melts into continuous fibers of nano/microscale diameters [ 53 ] and is the only method capable of mass‐producing continuous fibers at this range. [ 54 ]…”

Section: Background and Classificationmentioning

confidence: 99%

“…Among the processing techniques, including thermal-induced phase separation, drawing, template synthesis, and selfassembly, electrospinning is of considerable significance as a rapidly evolving fiber preparation method. [52] This highly versatile method is used to process solutions, suspensions, or melts into continuous fibers of nano/microscale diameters [53] and is the only method capable of mass-producing continuous fibers at this range. [54] Electrospinning is one of the most conventional methods used for continuous fiber preparation today and is based on the principle that electrostatic forces can be used to form and expand fibers out of a polymer solution.…”

Section: Principles and Process Parametersmentioning

confidence: 99%

The History of Electrospinning: Past, Present, and Future Developments

Keirouz

Wang

Reddy

et al. 2023

Adv Materials Technologies

118

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Electrospinning has rapidly progressed over the past few decades as an easy and versatile way to fabricate fibers with diameters ranging from micrometers to tens of nanometers that present unique and intricate morphologies. This has led to the conception of new technologies and diverse methods that exploit the basic electrohydrodynamic phenomena of the electrospinning process, which has in turn led to the invention of novel apparatuses that have reshaped the field. Research on revamping conventional electrospinning has principally focused on achieving three key objectives: upscaling the process while retaining consistent morphological traits, developing 3D nanofibrous macrostructures, and formulating novel fiber configurations. This review introduces an extensive group of diverse electrospinning techniques and presents a comperative study based on the apparatus type and output. Then, each process's advantages and limitations are critically assessed to identify the bona fide practicability and relevance of each technological breakthrough. Finally, the outlook on future developments of advanced electrospinning technologies is outlined, with an emphasis on upscaling, translational research, sustainable manufacturing and prospective solutions to current shortcomings.

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Nanobased Intravenous and Transdermal Drug Delivery Systems

Cited by 21 publications

References 133 publications

Chitosan Nanocomposites as Wound Healing Materials: Advances in Processing Techniques and Mechanical Properties

Chitosan Nanocomposites as Wound Healing Materials: Advances in Processing Techniques and Mechanical Properties

Untitled

The History of Electrospinning: Past, Present, and Future Developments

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