Nanobiosensors Based on Localized Surface Plasmon Resonance for Biomarker Detection

Hong, Yoochan; Huh, Yong Min; Yoon, Dae Sung; Yang, Jaemoon

doi:10.1155/2012/759830

Cited by 129 publications

(86 citation statements)

References 91 publications

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“…Such approaches of deliberately diminishing the smoothness of the as-deposited plasmonic film, might be promising in the development of FO-SPR instruments because, as already well-established with the planar SPR substrates [16], they could enhance the sensor's refractometric response, or eventually they could enable additional functionalities, like multiplexing [17] or localized SPR (LSPR) [18], [19], thus allowing parallel analysis of different target analytes [20] or detection of tiny biomolecules in low amounts [16], respectively. The optimized wet chemistry protocols enable the synthesis of a wide variety of nanomaterials (i.e.…”

Section: Introductionmentioning

confidence: 99%

Thermal annealing of gold coated fiber optic surfaces for improved plasmonic biosensing

Antohe

Schouteden

Goos

et al. 2016

Sensors and Actuators B: Chemical

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The morphological properties of thin gold (Au) films sputtered onto fiber optic (FO) substrates play an essential role in the overall performance of the sensing devices relying on surface plasmon resonance (SPR) effects. In this work, the influence of thermal treatments on the structural changes of the Au layer coated on the FO-SPR sensors, and consequently on their plasmonic biosensing performance, was systematically investigated. First, the sensors were exposed to different annealing temperatures for different durations and their sensitivity was evaluated by refractometric measurements in sucrose dilutions. The attained results suggested the optimal annealing conditions that were further validated using a split-plot experimental design statistical model. Room-temperature scanning tunneling microscopy (STM) imaging of the FO substrates revealed changes in the granular surface texture of the thermally treated Au films that could be linked to the observed increase in sensitivity of the treated sensors. The FO sensors, annealed under optimal conditions, were finally tested as label-free aptamer -based biosensors for the detection of Ara h 1 peanut allergen. Remarkably, the results demonstrated a superior biosensing performance of the thermally treated FO sensors, as the limit of detection (LOD) was improved with up to two orders of magnitude compared to a similar non-annealed FO-SPR sensor. This significant increase in sensitivity represents a major step forward in the facile and cost-effective preparation of FO-SPR sensors capable of label-free detection of various biomolecular targets.

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Section: Introductionmentioning

confidence: 99%

Thermal annealing of gold coated fiber optic surfaces for improved plasmonic biosensing

Antohe

Schouteden

Goos

et al. 2016

Sensors and Actuators B: Chemical

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“…2.3 Binding of target analyte to a recognition site and the corresponding red-shift of the LSPR peak [30] effective, as it does not rely on expensive equipment. Further, these sensors show good reproducibility using nanoparticle substrates and provide real-time assay accessibility using microfluidic systems [6]. These advantages demonstrate that nanobiosensors can be applied in a wide range of fields, such as medical, food safety, environmental monitoring, and drug screening.…”

Section: Advantagesmentioning

confidence: 97%

“…Optical channel waveguide sensors utilizing an evanescent field probing scheme have drawn great interests in biosensing due to its high sensitivity and label-free analyte detection [47]. Optical waveguides are comprised of an optically transparent guiding layer (waveguide core) with a refractive index that is higher than the substrate layer (or the cladding) [48].…”

Section: Propagation Of Light Through Waveguidementioning

confidence: 99%

“…Label-free biosensors such as localized surface plasmon resonance (LSPR)-based biosensors, with the potential of high-throughput and real-time analysis could make significant improvements in clinical diagnostics [6]. LSPR is a coherent, collective spatial oscillation of the conduction electrons in a metallic nanoparticle (NP), which is excited by electromagnetic radiation [7].…”

Section: Introductionmentioning

confidence: 99%

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OMCVD Gold Nanoparticles Covalently Attached to Polystyrene for Biosensing Applications

Kandeepan

Paquette

Gilroy

et al. 2015

Chemical Vapor Deposition

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“…In the past, the electron-beam lithography (EBL) [15] and photolithography [16] methods can be used to fabricate the nanoparticle arrays for LSPRs' structures. Nanosphere lithography (NSL) [17,18] is one of the most low-cost and high-efficiency methods for producing periodically and geometrically tunable nanostructure arrays. In this paper, at first, the DDA method was used to simulate and find the RIS and FOM values of the hybrid nanostructure arrays on glasses with different refractive indexes.…”

Section: Introductionmentioning

confidence: 99%

Effect of Refractive Index of Substrate on Fabrication and Optical Properties of Hybrid Au-Ag Triangular Nanoparticle Arrays

Wencai¹,

Xiaomeng²,

Zijie³

et al. 2015

激光与光电子学进展

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Abstract:In this study, the nanosphere lithography (NSL) method was used to fabricate hybrid Au-Ag triangular periodic nanoparticle arrays. The Au-Ag triangular periodic arrays were grown on different substrates, and the effect of the refractive index of substrates on fabrication and optical properties was systematically investigated. At first, the optical spectrum was simulated by the discrete dipole approximation (DDA) numerical method as a function of refractive indexes of substrates and mediums. Simulation results showed that as the substrates had the refractive indexes of 1.43 (quartz) and 1.68 (SF5 glass), the nanoparticle arrays would have better refractive index sensitivity (RIS) and figure of merit (FOM). Simulation results also showed that the peak wavelength of the extinction spectra had a red shift when the medium's refractive index n increased. The experimental results also demonstrated that when refractive indexes of substrates were 1.43 and 1.68, the nanoparticle arrays and substrate had better adhesive ability. Meanwhile, we found the nanoparticles formed a large-scale monolayer array with the hexagonally close-packed structure. Finally, the hybrid Au-Ag triangular nanoparticle arrays were fabricated on

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Nanobiosensors Based on Localized Surface Plasmon Resonance for Biomarker Detection

Cited by 129 publications

References 91 publications

Thermal annealing of gold coated fiber optic surfaces for improved plasmonic biosensing

Thermal annealing of gold coated fiber optic surfaces for improved plasmonic biosensing

OMCVD Gold Nanoparticles Covalently Attached to Polystyrene for Biosensing Applications

Effect of Refractive Index of Substrate on Fabrication and Optical Properties of Hybrid Au-Ag Triangular Nanoparticle Arrays

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