Nanobiotechnological strategies for toxigenic fungi and mycotoxin control

Abd-Elsalam, Kamel A.; Hashim, Ayat F.; Alghuthaymi, Mousa A.; Said-Galiev, É. E.

doi:10.1016/b978-0-12-804303-5.00010-9

Cited by 26 publications

(31 citation statements)

References 86 publications

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“…Parameters that should be taken into consideration before the application of a chemical detoxification method are their safety, cost, efficiency, and the extent to which the nutritional content or the organoleptic properties of the feed are negatively affected [ 100 ]. During the recent years, nanomaterials such as selenium-, zinc oxide-, or copper-nanoparticles have been used as mycotoxin binders, leading to their removal [ 113 ].…”

Section: Prevention Strategies and Detoxification Technologies Formentioning

confidence: 99%

Impact of Mycotoxins on Animals’ Oxidative Status

et al. 2021

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Mycotoxins appear to be the “Achilles’ heel” of the agriculture sector inducing enormous economic losses and representing a severe risk to the health of humans and animals. Although novel determination protocols have been developed and legislation has been implemented within Europe, the side effects of mycotoxins on the homeostatic mechanisms of the animals have not been extensively considered. Feed mycotoxin contamination and the effects on the antioxidant status of livestock (poultry, swine, and ruminants) are presented. The findings support the idea that the antioxidant systems in both monogastrics and ruminants are challenged under the detrimental effect of mycotoxins by increasing the toxic lipid peroxidation by-product malondialdehyde (MDA) and inhibiting the activity of antioxidant defense mechanisms. The degree of oxidative stress is related to the duration of contamination, co-contamination, the synergetic effects, toxin levels, animal age, species, and productive stage. Since the damaging effects of MDA and other by-products derived by lipid peroxidation as well as reactive oxygen species have been extensively studied on human health, a more integrated monitoring mechanism (which will take into account the oxidative stability) is urgently required to be implemented in animal products.

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Section: Prevention Strategies and Detoxification Technologies Formentioning

confidence: 99%

Impact of Mycotoxins on Animals’ Oxidative Status

et al. 2021

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“…Similarly, “Mentha piperita essential” oils (Figure 5a) and “Thyme essential” oils have been respectively encapsulated into chitosan‐cinnamic acid nanogel and chitosan‐benzoic acid nanogel for the improvement of antifungal activity (Beyki et al., 2014; Khalili et al., 2015). In addition, metal NPs have been considered as the most promising antifungal agents due to their outstanding antimicrobial properties that are caused by the large surface area to volume ratio (Abd‐Elsalam, Hashim, Alghuthaymi, & Said‐Galiev, 2017). At present, a great many metal NPs (e.g., Fe 2 O 3 , SWCNTs, CuNPs, and AgNPs) have been widely used as efficient antifungal agents against fungal (Abd‐Elsalam et al., 2017; Horky et al., 2018; Wang, Liu, Chen, Han, & Yuan, 2014).…”

Section: Applications Of Nanomaterials To Mycotoxin Controlmentioning

confidence: 99%

“…Moreover, the effects of AgNPs on the production of OTA, AFG1, AFG2, AFB1, and AFB2 were also evaluated by using the above fungal species (Gómez, Tarazona, Mateo, Jiménez, & Mateo, 2019). In addition, there are some other NPs such as MgO NPs, ZnO NPs, palladium‐modified nitrogen‐doped titanium oxide (TiON/PdO) NPs, and N, F co‐doped TiO 2 NPs reported against fungi (Abd‐Elsalam et al., 2017). Impressively, antifungal activity and photocatalytic disinfection mechanism of TiON/PdO NPs against F. graminearum macroconidia under the irradiation of visible light were also studied.…”

Section: Applications Of Nanomaterials To Mycotoxin Controlmentioning

confidence: 99%

“…At present, a great many metal NPs . Copyright 2017, Royal Society of Chemistry efficient antifungal agents against fungal (Abd-Elsalam et al, 2017;Horky et al, 2018;Wang, Liu, Chen, Han, & Yuan, 2014). Zinc oxide (ZnO) and copper oxide (CuO) have also been investigated as green and efficiently synergistic antifungal agents and can be used against different fungal pathogens, the cytotoxicity of which may be related to their surface charge (Xu et al, 2012).…”

Section: Antifungal Nanomaterials For the Inhibition Of Mycotoxin Productionmentioning

confidence: 99%

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Recent advances on emerging nanomaterials for controlling the mycotoxin contamination: From detection to elimination

Zhang

et al. 2020

Food Frontiers

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Mycotoxins, a toxic secondary metabolite, unpredictably, and unavoidably occur in foods and feeds, leading to adverse health impacts and enormous economic losses in the agriculture industry. Moreover, mycotoxin contamination has been a great threat for the public health and agriculture economy development worldwide. Therefore, the control of the mycotoxin contamination is of great importance and has caused rising concern worldwide. Recently, emerging nanomaterials have been promisingly applied in the control of mycotoxin contamination and have obtained many achievements. In this review, first of all, the type, occurrence, and toxicity of mycotoxins are simply discussed. Then, attentions are focused on the applications of emerging nanomaterials to controlling the mycotoxin contamination, including mycotoxin assay, the inhibition of mycotoxin production, the adsorption of mycotoxins, and mycotoxin elimination. In the end, the future opportunities and challenges on the toxicity, occurrence, and control of mycotoxins are tentatively put forward.

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“…The nanotechnology approach seems to be an encouraging, effective, and affordable way to reduce the health problems of mycotoxins in humans and animals. There are three different approaches to reduce mycotoxin risks: effects on mold and flour retention, mycotoxin, and minimization of toxic effects by various nanomaterials [ 7 , 8 , 9 ]. Chitosan and self-assembled benzoic acid polymers were synthesized, and it was found that the encapsulation of CS-BA nanogels significantly enhanced the half-life and antifungal activity properties of thyme oil against A. flavus strains [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

Copper-Chitosan Nanocomposite Hydrogels Against Aflatoxigenic Aspergillus flavus from Dairy Cattle Feed

Abd-Elsalam

Alghuthaymi

Shami

et al. 2020

JoF

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The integration of copper nanoparticles as antifungal agents in polymeric matrices to produce copper polymer nanocomposites has shown excellent results in preventing the growth of a wide variety of toxigenic fungi. Copper-chitosan nanocomposite-based chitosan hydrogels (Cu-Chit/NCs hydrogel) were prepared using a metal vapor synthesis (MVS) and the resulting samples were described by transmission electron microscopy (TEM), X-ray fluorescence analysis (XRF), and small-angle X-ray scattering (SAXS). Aflatoxin-producing medium and VICAM aflatoxins tests were applied to evaluate their ability to produce aflatoxins through various strains of Aspergillus flavus associated with peanut meal and cotton seeds. Aflatoxin production capacity in four fungal media outlets revealed that 13 tested isolates were capable of producing both aflatoxin B1 and B2. Only 2 A. flavus isolates (Af11 and Af 20) fluoresced under UV light in the A. flavus and parasiticus Agar (AFPA) medium. PCR was completed using two specific primers targeting aflP and aflA genes involved in the synthetic track of aflatoxin. Nevertheless, the existence of aflP and aflA genes indicated some correlation with the development of aflatoxin. A unique DNA fragment of the expected 236 bp and 412 bp bands for aflP and aflA genes in A. flavus isolates, although non-PCR fragments have been observed in many other Aspergillus species. This study shows the antifungal activity of Cu-Chit/NCs hydrogels against aflatoxigenic strains of A. flavus. Our results reveal that the antifungal activity of nanocomposites in vitro can be effective depending on the type of fungal strain and nanocomposite concentration. SDS-PAGE and native proteins explain the apparent response of cellular proteins in the presence of Cu-Chit/NCs hydrogels. A. flavus treated with a high concentration of Cu-Chit/NCs hydrogels that can decrease or produce certain types of proteins. Cu-Chit/NCs hydrogel decreases the effect of G6DP isozyme while not affecting the activity of peroxidase isozymes in tested isolates. Additionally, microscopic measurements of scanning electron microscopy (SEM) showed damage to the fungal cell membranes. Cu-Chit/NCS hydrogel is an innovative nano-biopesticide produced by MVS is employed in food and feed to induce plant defense against toxigenic fungi.

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Nanobiotechnological strategies for toxigenic fungi and mycotoxin control

Cited by 26 publications

References 86 publications

Impact of Mycotoxins on Animals’ Oxidative Status

Impact of Mycotoxins on Animals’ Oxidative Status

Recent advances on emerging nanomaterials for controlling the mycotoxin contamination: From detection to elimination

Copper-Chitosan Nanocomposite Hydrogels Against Aflatoxigenic Aspergillus flavus from Dairy Cattle Feed

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