Nanobodies as negative allosteric modulators for human calcium sensing receptor

Cui, Qianqian; Wang, Lu; Wang, Haonan; Chen, Xiaochen; Han, Li; Geng, Tengjie; Kou, Yongjun; Zhang, Wenqing; Dai, Mei; Qiao, Huarui; Sun, Zengchao; Li, Lingyun; Lan, Zhongyun; Xu, Hongxi; Xu, Jiaqiang; Dai, Yuanyuan; Geng, Yong

doi:10.1016/j.bbrc.2023.149401

Biochemical and Biophysical Research Communications

2024

DOI: 10.1016/j.bbrc.2023.149401

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Nanobodies as negative allosteric modulators for human calcium sensing receptor

Qianqian Cui,

Lu Wang,

Haonan Wang

et al.

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Cited by 4 publications

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The Impact of Nanobodies on G Protein–Coupled Receptor Structural Biology and Their Potential as Therapeutic Agents

Salom,

Wu,

Liu

et al. 2024

Mol Pharmacol

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The family of human G protein-coupled receptors (GPCRs) is comprised of about 800 different members, with about 35% of current pharmaceutical drugs targeting GPCRs.However, GPCR structural biology, necessary for structure-guided drug design, has lagged behind that of other membrane proteins, and it was not until the year 2000 when the first crystal structure of a GPCR (rhodopsin) was solved. Starting in 2007, the determination of additional GPCR structures was facilitated by protein engineering, new crystallization techniques, complexation with antibody fragments, and other strategies.More recently, the use of camelid heavy-chain-only antibody fragments (nanobodies) as crystallographic chaperones has revolutionized the field of GPCR structural biology, aiding in the determination of more than 340 GPCR structures to date. In most cases, the GPCR structures solved as complexes with nanobodies (Nbs) have revealed the binding mode of cognate or non-natural ligands; in a few cases, the same Nb has acted as an orthosteric or an allosteric modulator of GPCR signaling. In this review we summarize the multiple ingenious strategies that have been conceived and implemented in the last decade to capitalize on the discovery of nanobodies to study GPCRs from a structural perspective.

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Nanobodies as negative allosteric modulators for human calcium sensing receptor

Cited by 4 publications

References 47 publications

Targeting cytokines in psoriatic arthritis

Targeting cytokines in psoriatic arthritis

Allosteric antibodies: a novel paradigm in drug discovery

The Impact of Nanobodies on G Protein–Coupled Receptor Structural Biology and Their Potential as Therapeutic Agents

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